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  4. Mouse CXC-chemokine ligand 16,CXCL16 ELISA Kit

Mouse CXC-chemokine ligand 16,CXCL16 ELISA Kit

  • 中文名稱：
    小鼠CXC趨化因子配體16(CXCL16)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E08873m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠CXC趨化因子配體16(CXCL16)酶聯(lián)免疫試劑盒（CSB-E08873m）檢測(cè)血清、血漿,組織勻漿樣本中的CXCL16含量。CXCL16是重要靶點(diǎn)。背景上，它在免疫調(diào)節(jié)等生理過程中有作用，且與多種疾病發(fā)展相關(guān)。研究機(jī)制方面，其與受體結(jié)合介導(dǎo)細(xì)胞間信號(hào)傳導(dǎo)，參與炎癥反應(yīng)、腫瘤細(xì)胞遷移等，為相關(guān)疾病治療提供潛在方向。試劑盒檢測(cè)范圍為7.8125 pg/mL-500 pg/mL，靈敏度為3.012 pg/mL。適用于科研場(chǎng)景下炎癥相關(guān)動(dòng)物模型構(gòu)建、藥物干預(yù)效果評(píng)估或免疫調(diào)控機(jī)制研究，特別針對(duì)心血管疾病、自身免疫性疾病等領(lǐng)域的實(shí)驗(yàn)需求，能夠穩(wěn)定檢測(cè)低豐度CXCL16分子，為探索其生物學(xué)功能提供可靠數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cxcl16 ELISA Kit; SrpsoxC-X-C motif chemokine 16 ELISA Kit; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein ELISA Kit; SR-PSOX ELISA Kit; Small-inducible cytokine B16 ELISA Kit; Transmembrane chemokine CXCL16 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測(cè)范圍：
    7.8125 pg/mL-500 pg/mL
  • 靈敏度：
    3.012 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

    　

    Intra-Assay Precision

    Inter-Assay Precision

    Sample

    1

    2

    3

    1

    2

    3

    n

    20

    20

    20

    20

    20

    20

    Mean(pg/ml)

    56.742

    57.876

    60.126

    58.666

    59.902

    61.355

    SD

    0.032

    0.028

    0.031

    0.029

    0.032

    0.036

    CV(%)

    6.026

    5.176

    5.526

    5.292

    5.725

    6.294

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse CXCL16 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    89

    Range %

    83-95

    1:2

    Average %

    102

    Range %

    96-108

    1:4

    Average %

    99

    Range %

    93-105

    1:8

    Average %

    92

    Range %

    86-98

  • 回收率：

    The recovery of mouse CXCL16 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    88

    82-94

    EDTA plasma (n=4)

    95

    90-101

    SAMPLE VALUES

    Serum/Plasma - Samples from apparently healthy volunteers were evaluated for the presence of mouse CXCL16 in this assay. No medical histories were available for the donors used in this study.

    Sample Type

    Mean (pg/mL)

    Range (pg/mL)

    Serum (n=70)

    702

    554-1002

    EDTA plasma (n=45)

    689

    401-902

    Heparin plasma (n=35)

    722

    504-1186

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    500

    2.531

    2.585

    2.558

    2.450

    250

    1.959

    1.945

    1.952

    1.844

    125

    1.213

    1.180

    1.196

    1.088

    62.5

    0.516

    0.521

    0.519

    0.411

    31.25

    0.344

    0.354

    0.349

    0.241

    15.625

    0.226

    0.235

    0.231

    0.123

    7.8125

    0.156

    0.168

    0.162

    0.054

    0

    0.113

    0.103

    0.108

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis.
  • 基因功能參考文獻(xiàn)：
    1. the results of the present study suggested that CXCL16 may regulate the TRL4/NFkappaB/CXCL16 signaling pathway, and that miR146a and miR146b may negatively regulate CXCL16 via this pathway in atherosclerosis in vivo. PMID: 30015963
    2. Inflammation accelerates renal tubulointerstitial lesions in mouse model of diabetic nephropathy by increasing the activity of CXCL16 pathway. PMID: 29620052
    3. CXCL16 increases the frequency of the miniature excitatory synaptic currents (mEPSCs) and reduces the PPR of evoked excitatory transmission, indicating that the chemokine also modulates and enhances the release of glutamate. PMID: 27721466
    4. results indicate that CXCL16 plays a key role in the pathogenesis of renal injury and fibrosis in salt-sensitive hypertension through regulation of bone marrow-derived fibroblast accumulation and macrophage and T cell infiltration. PMID: 27353044
    5. Data indicate that chemokine C-X-C ligand 16 (CXCL16) is a critical regulator of liver immune response to acetaminophen (APAP)-induced hepatotoxicity, suggesting a potential strategy for the treatment of drug-induced acute liver failure by targeting CXCL16. PMID: 28459937
    6. CXCL16 plays a crucial role in the pathogenesis of cisplatin-induced acute kidney injury through regulation of apoptosis and inflammation. PMID: 27191747
    7. These findings suggest that the CXCL16 gene product promotes inflammatory factors and cell infiltration factors, and inhibits the expression of antioxidant factors to accelerate the development of DN, and CXCL16 deficiency attenuates DN may be involved in the AKT signaling pathway. PMID: 28478039
    8. Results indicate that CXCL16 plays a pivotal role in the pathogenesis of renal artery stenosis-induced renal injury and fibrosis through regulation of bone marrow-derived fibroblast accumulation and macrophage and T-cell infiltration. PMID: 27496882
    9. Simvastatin exerts a protective effect on renal function and structure in mice with ADR nephropathy which related to the decreasing expression of CXCL16 in glomerular podocytes followed by the decreasing endocytosis of ox-LDL in podocytes and inhibition of NF-kappaB pathway activation. PMID: 26884839
    10. Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy PMID: 25661686
    11. injured hepatocytes up-regulated CXCL16 expression, indicating that scavenging functions of CXCL16 might be additionally involved in the pathogenesis of NAFLD. PMID: 25372401
    12. role of IFN-gamma, CXCL16, and ADAM10 in oxLDL-induced lipid accumulation in glomerular podocytes PMID: 24752304
    13. CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-alpha-induced apoptosis by tumor-associated macrophages. PMID: 25495942
    14. CXCL16 was constitutively expressed by CX3CR1(+) intestinal dendritic cells (DCs) and coexpressed with IL-23 after Citrobacter rodentium infection. PMID: 25456160
    15. CXCL16 expression inhibits liver metastasis in a murine model of colorectal cancer. PMID: 23242131
    16. our results indicate that CXCL16 plays a pivotal role in the pathogenesis of angiotensin II-induced renal injury and fibrosis through regulation of macrophage and T cell infiltration and bone marrow-derived fibroblast accumulation. PMID: 24060897
    17. Renal dendritic cell-derived CXCL16 might attract protective CXCR6(+) iNKT cells. PMID: 23138484
    18. CXCL16 triggers platelet activation and adhesion via CXCR6 phosphatidylinositide 3-kinase/Akt signaling and paracrine activation, suggesting a decisive role for CXCL16 in linking vascular inflammation and thrombo-occlusive diseases. PMID: 22927331
    19. Induction of experimental autoimmune encephalomyelitis leads to expression of CXCL10 and CXCL16 in immature myeloid cells of draining lymph nodes, in an interferon (IFN)-gamma-dependent manner. PMID: 22287719
    20. regulation of CXCL16, ADAM10 and oxLDL expression may be an early event in the onset of diabetic nephropathy PMID: 19426159
    21. contributes to the pathogenesis of renal fibrosis by recruiting bone marrow-derived fibroblast precursors PMID: 21816936
    22. Data show that CXCL16 becomes much higher in atherosclerosis, and it could be a potential atherogenic biomarker. PMID: 21177121
    23. This study implicates CXCL16 as an additional neutrophil chemoattractant in cerebrospinal fluid in early pneumococcal meningitis. PMID: 20874518
    24. An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells. PMID: 20181724
    25. Overall, our data indicate that up-regulation of CXCL16 is a common response of tumor cells to radiation, and they have important implications for the use of local radiotherapy in combination with immunotherapy. PMID: 20334513
    26. CXCL16 expression is a critical mediator of muscle regeneration PMID: 19893053
    27. SR-PSOX/CXCL16 may be involved in CD8+ T cell recruitment through VLA-4 activation and stimulation of IFN-[gamma] production by CD8+ T cells during inflammatory valvular heart disease. PMID: 14699018
    28. SR-PSOX/CXCL16 plays important roles in EAE by supporting generation of Ag-specific T cells, as well as recruitment of inflammatory mononuclear cells into the CNS. PMID: 15265890
    29. increased IFN-gamma, accompanied by elevation of the scavenger receptor/chemokine CXCL16, was observed in both lesions and spleens after IL18 administration PMID: 15604417
    30. CXCL16, the cell surface ligand for CXCR6, is expressed on sinusoidal endothelial cells, and CXCR6 deficiency resulted in reduced survival in liver natural killer cells. PMID: 15799695
    31. Transmembrane chemokine CXCL16 is expressed in the brain by malignant and inflamed astroglial cells, shed to a soluble form and targets not only activated T cells but also glial cells themselves. PMID: 15934948
    32. CXCL16 plays a unique role in the maintenance of cardiac allograft tolerance mediated by natural killer T cells. PMID: 16081769
    33. CXCL16 is involved in immunological liver injury by regulating T lymphocyte infiltration in liver tissue PMID: 16124049
    34. findings suggest that CXCL16 is an important mediator of lymphocyte-stromal interaction within lymphoid tissues PMID: 16410312
    35. These data suggest that scavenger receptor activity mediated by CXCL16 in vivo is atheroprotective. PMID: 16880330
    36. These results demonstrate a role for CXCL16 in the control of bacterial colonization of target organs and, more specifically, in the regulation of the cell-mediated arm of the primary response to S. enteritidis. PMID: 16982830
    37. CXCL16 is constitutively expressed on the surface of epidermal keratinocytes, released upon cell activation or photodamage and may then target CXCR6-expressing T cells in the dermis PMID: 17363916
    38. SR-PSOX/CXCL16 plays an important role in not only the production of IFN-gamma by NKT cells, but also promotion of Th1-inclined immune responses mediated by NKT cells. PMID: 18056360
    39. Hyperhomocysteinemia up-regulates CXCL16 leading to increased recruitment of CXCR6(+) lymphocytes and scavenging of modified lipids via a potential involvement of a PPAR-gamma-dependent mechanism PMID: 18194461
    40. Data show that the chemokine receptor CXCR6 is highly expressed on glial precursor cells (GPCs) and is induced by its ligand, and that GPCs proliferate and migrate to the sites of CXCL16 production. PMID: 18619850
    41. Ionizing radiation markedly enhanced the secretion by mouse and human breast cancer cells of CXCL16; irradiation increased the migration of CD8(+)CXCR6(+) activated T cells to tumors PMID: 18713980
    42. Report increased production of CXCL16 in experimental heart failure: a possible role in extracellular matrix remodeling. PMID: 19919988

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 組織特異性：
    Widely expressed. Not detected in purified B- and T-cells.
  • 數(shù)據(jù)庫(kù)鏈接：