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  4. Mouse Clara cell protein,CC16 ELISA Kit

Mouse Clara cell protein,CC16 ELISA Kit

  • 中文名稱：
    小鼠克拉拉細(xì)胞蛋白(CC16)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E08682m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠克拉拉細(xì)胞蛋白(CC16)酶聯(lián)免疫試劑盒（CSB-E08682m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CC16含量。CC16是一種由呼吸道上皮的club細(xì)胞分泌的蛋白質(zhì)，具有抗炎、免疫調(diào)節(jié)、抗纖維化等多種生物學(xué)功能。研究表明，CC16在慢性氣道疾病的發(fā)病機(jī)制中起到重要作用，可能成為慢性氣道疾病的潛在生物標(biāo)志物和治療靶點(diǎn)。CC16通過抑制炎癥、調(diào)節(jié)細(xì)胞因子表達(dá)和阻斷NF-κB信號通路等機(jī)制發(fā)揮其保護(hù)作用。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，適用于小鼠呼吸系統(tǒng)疾病模型研究，包括肺損傷評估、炎癥反應(yīng)監(jiān)測及環(huán)境污染物暴露研究，尤其適合通過血清或血漿樣本動態(tài)追蹤體內(nèi)CC16水平變化，或通過肺組織勻漿分析局部蛋白表達(dá)。為科研人員探究CC16在肺部病理生理機(jī)制中的作用提供可靠工具，也可用于藥物干預(yù)效果評價中的生物標(biāo)志物檢測。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Scgb1a1 ELISA Kit; Cc10 ELISA Kit; Ugb ELISA Kit; Utg ELISA Kit; Uteroglobin ELISA Kit; Clara cell 17 kDa protein ELISA Kit; Clara cell phospholipid-binding protein ELISA Kit; CCPBP ELISA Kit; Clara cells 10 kDa secretory protein ELISA Kit; CC10 ELISA Kit; PCB-binding protein ELISA Kit; Secretoglobin family 1A member 1 ELISA Kit
  • 縮寫：
    CC16
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse CC16 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %85
    Range %80-90
    1:2Average %96
    Range %90-100
    1:4Average %98
    Range %91-103
    1:8Average %92
    Range %85-98
  • 回收率：
    The recovery of mouse CC16 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9792-104
    EDTA plasma (n=4)9591-101
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.095 1.962 2.029 1.868
    51.268 1.176 1.222 1.061
    2.50.755 0.704 0.730 0.569
    1.250.490 0.469 0.480 0.319
    0.6250.336 0.324 0.330 0.169
    0.3120.265 0.259 0.262 0.101
    0.1560.212 0.209 0.211 0.050
    00.164 0.157 0.161 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
  • 基因功能參考文獻(xiàn)：
    1. the present results demonstrate that rCC16 has therapeutic effects on COPD by downregulating proinflammatory factors via the NFkappaB pathway. PMID: 29956762
    2. This study extends the function of the Scgb1a1-expressing epithelial cell population as a major mediator of the antiviral response. It PMID: 29593031
    3. Chronic P. aeruginosa inflammation resulted in chronic bronchitis and emphysematous changes in CCSP-deficient mice. PMID: 27703342
    4. CC16 protects lungs from cigarette smoke (CS)-induced injury by reducing lung NF-kappaB activation. CS-induced airway CC16 deficiency increases CS-induced pulmonary inflammation and injury and likely contributes to the pathogenesis of COPD. PMID: 25700379
    5. Depletion of bone marrow CCSP-expressing cells delays airway regeneration. PMID: 25409745
    6. Serum CC-16 is associated with disease progression in chronic obstructive pulmonary disease (COPD). However, the absence of CC-16 does not appear to modify the risk of cigarette-related COPD in mice. PMID: 24245748
    7. These findings indicate that CCSP has a regulatory role in obliterative bronchiolitis. PMID: 23997179
    8. the role of clara cells and clara cell secretory protein in lung radiation injury exacerbated by viral infection PMID: 23621375
    9. AAV2/9-CC10 vector virus guaranteed sufficient CC10 expression and had an anti-inflammatory effect in asthmatic mice. PMID: 23013277
    10. Claudin-3 and Clara cell 10 kDa protein were identified as possible markers of early tobacco smoke-induced epithelial injury along alveolar ducts. PMID: 22659244
    11. Scgb1a1-expressing cells, most likely Clara cells, are a major cell type that gives rise to alveolar type I and II cells during the regeneration of alveolar epithelia in response to severe pulmonary damage in mice. PMID: 23119022
    12. These results indicate that CC10 gene transfer may inhibit airway inflammation through suppressing the activation of NF-kappaB. PMID: 22558282
    13. Clara cell secretory protein expression is elevtaed in lungs after long-term n-hexane inhalation exposure. PMID: 20853679
    14. CCSP promoter has a role in alveolar development PMID: 20693404
    15. The expression of CC10 is downregulated in sinonasal mucosa in bacterial chronic rhinosinusitis. PMID: 19119605
    16. Expression of SCGB1A1 mRNA was not decreased in vivo in the absence of C/EBPs. PMID: 21224212
    17. The differential expression of mRNA by both airway level and lung region was determined for Clara cell secretory protein. PMID: 20852037
    18. Lack of uteroglobin in mice enhances colonization of B16F10 melanoma cells in the lungs. PMID: 20118237
    19. macrophages from Clara cell-depleted and CCSP(-/-) mice displayed increased Toll-like receptor 4 surface expression PMID: 19423773
    20. Uteroglobin promoter-targeted c-MYC expression in transgenic mice cause hyperplasia of Clara cells and malignant transformation of T-lymphoblasts and tubular epithelial cells PMID: 11817538
    21. Data show that Clara cell secretory protein (CCSP) is required for the appearance of secretory granules and that functional changes to Clara cells that result from CCSP deficiency lead to alterations in the composition of epithelial lining fluid. PMID: 12151308
    22. demonstrate synergistic transactivation by C/EBPalpha and Nkx2.1 in the regulation of the CCSP gene PMID: 12161423
    23. An immunohistochemical analysis was made of the expression of this protein in a transgenic model of mouse lung carcinogenesis. PMID: 12699910
    24. Restoration of CCSP in the airways of CCSP-deficient mice abrogates the increase in viral persistence, lung inflammation, and airway hyperreactivity induced by respiratory syncytial virus infection. PMID: 12847279
    25. Multiple mechanisms for repression of the Clara cell secretory protein gene during hyperoxia. PMID: 14500549
    26. Data show that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone exposure of Clara cell 10-kDa protein knock-out mice causes a significantly higher incidence of airway epithelial hyperplasia and lung adenomas compared with wild type littermates. PMID: 15148323
    27. plays a direct role in the regulation of T-cell-mediated inflammatory responses. PMID: 15356574
    28. We propose that mechanical activation of the cPLA2 pathway contributes to acute high PIP-induced lung injury and that CCSP may reduce this injury through inhibition of the cPLA2 pathway and reduction of proinflammatory products produced by this pathway. PMID: 15608088
    29. Uteroglobin suppresses SCCA gene expression associated with airway inflammation in asthma PMID: 15677460
    30. uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response by inhibiting the prostaglandin F2alpha receptor PMID: 16061484
    31. A critical role for uteroglobin in preventing the development of pulmonary fibrosis. PMID: 16872605
    32. These results suggest that both long- and short-range paracrine signaling between nonciliated secretory cells and cells of the immune system and epithelium impact modification of cell type-specific proteins. PMID: 17384087
    33. Treatment of lung neoplasms with bexarotene resulted in decreased mRNA expression. PMID: 17849452
    34. Clara cells accumulated Clara cell secretory protein (CCSP) in Munc13-2-deficient mice. PMID: 18258655
    35. preferentially expressed in mouse model of allergen-induced airway inflammation and remodeling PMID: 19322781

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family
  • 組織特異性：
    Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:22287

    STRING: 10090.ENSMUSP00000025554

    UniGene: Mm.2258