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  4. Mouse Collagen alpha-1(V) chain (COL5A1) ELISA kit

Mouse Collagen alpha-1(V) chain (COL5A1) ELISA kit

  • 中文名稱：
    小鼠V型膠原α1鏈(COL5A1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL005748MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠V型膠原α1鏈(COL5A1)酶聯(lián)免疫試劑盒（CSB-EL005748MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的COL5A1含量。COL5A1是一種基因，其編碼的V型膠原蛋白是細(xì)胞外基質(zhì)的重要成分。研究發(fā)現(xiàn)它與腫瘤進(jìn)展密切相關(guān)，參與調(diào)控腫瘤細(xì)胞的增殖、遷移和侵襲。在腫瘤微環(huán)境中，COL5A1表達(dá)變化會(huì)影響細(xì)胞信號(hào)傳導(dǎo)等機(jī)制，正成為腫瘤治療研究的潛在靶點(diǎn)。試劑盒檢測(cè)范圍為0.312 ng/ml-20 ng/ml，本試劑盒適用于基礎(chǔ)科研領(lǐng)域，可應(yīng)用于結(jié)締組織相關(guān)疾病模型研究、組織修復(fù)機(jī)制探索或膠原代謝調(diào)控實(shí)驗(yàn)中目標(biāo)蛋白的定量檢測(cè)。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    Col5a1Collagen alpha-1(V) chain ELISA kit
  • 縮寫：
    COL5A1
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.312 ng/ml -20 ng/ml
  • 靈敏度：
    0.078 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

相關(guān)問(wèn)答

■ 常見(jiàn)問(wèn)題解答
Q:

Per customers request, please provide the following information regarding Mouse Collagen alpha-1 (V) chain, COL5A1 ELISA Kit CSB-EL005748MO
1. Please provide current manual
2. If competitive please provide following information:
a. What is the standard?
b. What is the immunogen this kit detects? Sequence Range?
c. What is the antibody in this kit?
3. If Sandwich please provide the following information:
a. What is the standard? (Recombinant full-length protein? Partial protein (range?)?, peptide (sequence range?), native protein?)
b. If recombinant protein, then what is the host?
c. Is the capture antibody a monoclonal or polyclonal?
d. What is the host of the capture antibody?
e. What is the immunogen of the capture antibody?
f. Is the detection antibody a monoclonal or polyclonal?
g. What is the host of the detection antibody?
h. What is the immunogen of the detection antibody?

A:
Thanks for your inquiry!
CSB-EL005748MO
Pls find attached manual.
This kit is based on double antibody sandwich method. Pls refer to: https://www.uniprot.org/uniprot/O88207.
Capture antibody is rabbit polyclonal antibody and detection antibody is rabbit polyclonal antibody.
Immunogen is 293 cell-derived recombinant protein.
Standard is 293 cell-derived recombinant protein.

靶點(diǎn)詳情

  • 功能：
    Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Transcriptionally activated by CEBPZ, which recognizes a CCAAT-like motif, CAAAT in the COL5A1 promoter.
  • 基因功能參考文獻(xiàn)：
    1. COL5A1 may contribute the metastasis of lung adenocarcinoma. PMID: 29702185
    2. Significantly decreased fibroblast proliferation was observed in Col5a1(+/-) compared to Col5a1(+/+) fibroblasts. PMID: 26713685
    3. Col5a1 knockout stroma demonstrated severe dysfunctional regulation of fibrillogenesis. PMID: 22159420
    4. Sp7/Osterix was observed to participate in the activation of the Col5a1 promoter during osteoblast differentiation. PMID: 20888414
    5. Col(V) is an established autoantigen in atherosclerotic mice, and Col(V) autoimmunity is a consistent feature, with variable T helper type (Th)1 cell pathway involvement. PMID: 20814021
    6. analysis of processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer PMID: 15136578
    7. CBF activated the Col5a1 promoter suggesting that CBF is a key factor in the coordinated expression of type I and V collagen genes PMID: 15246108
    8. collagen type V has a critical role in early fibril initiation PMID: 15383546
    9. COL5A1 is regulated by TGF-beta in osteoblasts PMID: 15579311
    10. col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages PMID: 16492673
    11. Type V collagen contributes to the development of functional connective tissues during embryogenesis. PMID: 17024418
    12. ColVa1+/- and ColXIa1-/- mutants were used to identify roles for ColVa1 and ColXIa1 in ventricular myocardial morphogenesis and heart valve development. PMID: 17029294

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  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibrillar collagen family
  • 組織特異性：
    Widely expressed. Isoform 2 is more highly expressed in liver, kidney and lung.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:12831

    STRING: 10090.ENSMUSP00000028280

    UniGene: Mm.7281