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  4. Mouse Complement C1q tumor necrosis factor-related protein 3(C1QTNF3) ELISA kit

Mouse Complement C1q tumor necrosis factor-related protein 3(C1QTNF3) ELISA kit

  • 中文名稱：
    小鼠補(bǔ)體C1q腫瘤壞死因子相關(guān)蛋白3(C1QTNF3)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL003648MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠補(bǔ)體C1q腫瘤壞死因子相關(guān)蛋白3(C1QTNF3)酶聯(lián)免疫試劑盒（CSB-EL003648MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的C1QTNF3含量。C1QTNF3是一種靶點(diǎn)。它在相關(guān)生理病理過(guò)程中的作用正被研究。其研究機(jī)制或圍繞其在細(xì)胞信號(hào)傳導(dǎo)、代謝調(diào)控等方面展開(kāi)，探索它與疾病發(fā)生、發(fā)展的關(guān)系，有望為某些疾病的診斷和治療提供新方向。試劑盒檢測(cè)范圍為3.12 ng/mL-200 ng/mL，支持科研人員高效分析小鼠模型中C1QTNF3的表達(dá)動(dòng)態(tài)，適用于代謝疾病機(jī)制研究、藥物干預(yù)效果評(píng)估或相關(guān)信號(hào)通路探索等實(shí)驗(yàn)場(chǎng)景，為肥胖、糖尿病及心血管疾病等基礎(chǔ)研究提供標(biāo)準(zhǔn)化工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    C1qtnf3 ELISA Kit; Cors26 ELISA Kit; Ctrp3 ELISA Kit; Complement C1q tumor necrosis factor-related protein 3 ELISA Kit; Collagenous repeat-containing sequence 26 kDa protein ELISA Kit; CORS26 ELISA Kit; Secretory protein CORS26 ELISA Kit
  • 縮寫(xiě)：
    C1QTNF3
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    3.12 ng/mL-200 ng/mL
  • 靈敏度：
    0.78 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse C1QTNF3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 92
    Range % 87-96
    1:2 Average % 101
    Range % 97-106
    1:4 Average % 93
    Range % 86-97
    1:8 Average % 91
    Range % 87-95
  • 回收率：
    The recovery of mouse C1QTNF3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 96 92-101
    EDTA plasma (n=4) 98 94-102
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    200 2.123 2.268 2.196 2.045
    100 1.478 1.548 1.513 1.362
    50 0.941 0.958 0.950 0.799
    25 0.586 0.597 0.592 0.441
    12.5 0.412 0.403 0.408 0.257
    6.25 0.302 0.309 0.306 0.155
    3.12 0.218 0.224 0.221 0.070
    0 0.150 0.151 0.151 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Low C1QTNF3 expression is associated with polycystic ovarian syndrome. PMID: 29438034
    2. Although it is dispensable for physiological control of energy balance, CTRP3 plays a previously unsuspected role in modulating liver size and circulating cytokine levels in response to obesity. PMID: 26670485
    3. CTRP3 was expressed in developing skeletal muscle tissues, and the expression level of CTRP3 was increased during myogenic differentiation of C2C12 cells. PMID: 26272338
    4. Our study suggests that CTRP3 prevents osteoclast differentiation PMID: 26103094
    5. Data suggest that CTRP3 up-regulates expression and secretion of adipokines (adiponectin, leptin, visfatin, and apelin) in adipocytes; these responses to CTRP3 are down-regulated by insulin resistance or inhibition of AMPK signaling pathway. PMID: 25168658
    6. present study shows the proof of principle that the novel adipokine CTRP-3 is a potent inhibitor of LPS-induced systemic inflammation and LPS-induced signaling in adipose tissue in vivo PMID: 24996172
    7. CTRP3 promotes vascular calcification by enhancing phosphate-induced osteogenic transition of VSMC through reactive oxygen species-extracellular signal-regulated kinase 1/2-Runx2 pathway. PMID: 24578384
    8. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat rheumatoid arthritis. PMID: 24269820
    9. results establish a novel role for C1q tumor necrosis factor-related protein 3 (CTRP3) in regulating hepatic lipid metabolism and highlight its protective function and therapeutic potential in attenuating hepatic steatosis PMID: 23744740
    10. c-Jun is a cis-acting element for CTRP3 regulation in chondrogenic cells. PMID: 22644487
    11. CTRP3 is a novel antiapoptotic, proangiogenic, and cardioprotective adipokine, the expression of which is significantly inhibited after myocardial infarction. PMID: 22653084
    12. This study provides the first functional evidence linking CTRP3 to hepatic glucose metabolism and establishes CTRP3 as a novel adipokine. PMID: 20952387
    13. Exogenous CTRP3/cartducin promoted the proliferation of p53LMAC01 cells in a dose-dependent manner via ERK1/2 (extracellular signal-regulated kinase 1/2)- and MAPK (p38 mitogen-activated protein kinase)-signalling pathways PMID: 19947921
    14. Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 PMID: 12850274
    15. the murine CORS-26 promoter is transcriptionally regulated by specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 PMID: 15157741
    16. Cartducin is a novel growth factor and plays important roles in regulating both chondrogenesis and cartilage development by its direct stimulatory action on the proliferation of chondrogenic precursors and chondrocytes. PMID: 16155912
    17. CORS-26 up-regulates adipokine secretion and might be involved in metabolic and immunologic pathways. PMID: 17299102
    18. Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation PMID: 19424626

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  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫(kù)鏈接：