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Mouse Complement C1q tumor necrosis factor-related protein 6(C1QTNF6) ELISA kit

  • 中文名稱:
    小鼠補(bǔ)體C1q腫瘤壞死因子相關(guān)蛋白6(C1QTNF6)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-EL003651MO
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠補(bǔ)體C1q腫瘤壞死因子相關(guān)蛋白6(C1QTNF6)酶聯(lián)免疫試劑盒(CSB-EL003651MO)檢測(cè)樣本中的C1QTNF6含量。C1QTNF6是一種與炎癥和代謝相關(guān)的基因,其表達(dá)與多種疾病如1型糖尿病、多囊卵巢綜合征等密切相關(guān)。研究顯示,C1QTNF6在相關(guān)疾病中的表達(dá)異??赡芡ㄟ^(guò)調(diào)節(jié)炎癥反應(yīng)和代謝途徑影響疾病進(jìn)程。該產(chǎn)品適用于基礎(chǔ)科研中探索C1QTNF6在代謝性疾病、慢性炎癥或癌癥發(fā)生發(fā)展中的作用機(jī)制,亦可用于評(píng)估藥物干預(yù)或基因編輯模型下靶蛋白的調(diào)控效果。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名:
    C1qtnf6Complement C1q tumor necrosis factor-related protein 6 ELISA Kit
  • 縮寫(xiě):
    C1QTNF6
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 檢測(cè)范圍:
    Request Information
  • 靈敏度:
    Request Information
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Others
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. The results establish CTRP6 as a novel metabolic/immune regulator linking obesity to adipose tissue inflammation and insulin resistance. PMID: 28726640
    2. CTRP6 knockdown down-regulated the levels of lipogenic genes and phosphorylated Erk1/2 (p-Erk1/2) in the early lipogenic stage, whereas up-regulated p-Erk1/2 in the terminal differentiation in skeletal myoblasts. PMID: 27125977
    3. CTRP6 specifically suppresses the alternative pathway of the complement system. C1qtnf6(-/-) mice are highly susceptible to induced arthritis, Arthus reaction, and experimental autoimmune encephalomyelitis. PMID: 26404464
    4. Knockdown of CTRP6 can inhibit adipogenesis of 3T3-L1 adipocytes through lipogenic marker genes and Erk1/2 signaling pathway. PMID: 25639984
    5. CTRP6 plays a role in fatty acid metabolism via the AMPK-ACC pathway. The globular domain of CTRP6 mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) in skeletal muscle cells. PMID: 20102710

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  • 亞細(xì)胞定位:
    Secreted.
  • 數(shù)據(jù)庫(kù)鏈接: