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  4. Mouse Cystatin C,Cys-C ELISA Kit

Mouse Cystatin C,Cys-C ELISA Kit

  • 中文名稱：
    小鼠半胱氨酸蛋白酶抑制劑/胱抑素C(Cys-C)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E08386m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠半胱氨酸蛋白酶抑制劑/胱抑素C(Cys-C)酶聯(lián)免疫試劑盒（CSB-E08386m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CST3含量。CST3 是一種重要靶點。它與多種生理病理過程相關(guān)，如在神經(jīng)系統(tǒng)的調(diào)控、免疫反應(yīng)等方面發(fā)揮作用。研究機制上，主要聚焦于其蛋白表達調(diào)控、與其他分子的相互作用，以揭示其在疾病發(fā)生發(fā)展中的具體作用機制，為相關(guān)疾病治療提供靶點思路。試劑盒檢測范圍為2.5 ng/mL-160 ng/mL，靈敏度為0.819 ng/mL。該產(chǎn)品適用于基礎(chǔ)科研中對小鼠模型腎小球濾過功能評估、藥物干預下Cys-C動態(tài)監(jiān)測、組織特異性表達分析等場景，如構(gòu)建急性腎損傷、糖尿病腎病等疾病模型的研究，或探究心血管疾病、神經(jīng)退行性疾病中Cys-C的調(diào)控機制，為體外實驗提供穩(wěn)定可靠的檢測工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cst3Cystatin-C ELISA Kit; Cystatin-3 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    2.5 ng/mL-160 ng/mL
  • 靈敏度：
    0.819 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

     Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess. 
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess. 
  • 線性度：

     To assess the linearity of the assay, samples were spiked with high concentrations of mouse Cys-C in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

  • 標準曲線：

     These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 最新研究進展：
    CST3也被稱為半胱氨酸蛋白酶抑制劑或腎素抑制劑。它是一種廣泛存在于生物體中的囊泡蛋白，可作為生物標記物用于疾病的診斷和預后評估。最近的研究表明，CST3可能在心血管疾病、神經(jīng)退行性疾病、腫瘤、糖尿病等疾病的發(fā)生和發(fā)展中發(fā)揮重要作用，因此被認為是潛在的治療靶點。此外，一些研究表明CST3在腎臟疾病中發(fā)揮重要作用，因為它與腎小管損傷和腎功能下降相關(guān)。
     
  • 功能：
    As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
  • 基因功能參考文獻：
    1. CysC plays an important regulatory role in combating cell death via the autophagic pathway in atherosclerosis. PMID: 27079462
    2. Data (including data from studies in mutant mice) suggest that up-regulation of Cst3, as observed in plasma of mice with type 2 diabetes, down-regulates insulin signaling and promotes endoplasmic reticulum stress in hepatocytes but not in myotubes. PMID: 26592151
    3. Cystatin C is a potential pathogenic signal triggering neurodegeneration in multiple system atrophy. PMID: 24405769
    4. The neuroprotective activity of CysC against Amyotrophic lateral sclerosis-linked mutant Cu/Zn-superoxide dismutase (SOD1)-mediated toxicity. PMID: 25356866
    5. an important role for macrophages, DC, and ROS in diseases associated with the protease inhibitory activity or amyloidogenic properties of cystatin C. PMID: 24570004
    6. APP expression stimulates NSPC proliferation; this effect is mediated via an increase in cystatin C secretion PMID: 23671283
    7. Cystatin C, a protein targeted to the classical secretory pathway by its signal peptide sequence, is secreted by primary neurons in at least 9 different cystatin C glycoforms associated with exosomes. PMID: 19773092
    8. The lack of cystatin C enhances Collagen-induced arthritis and primarily affects in vivo priming of the immune system PMID: 21443774
    9. Inflammation causes downregulation of cystatin C expression in dendritic cells and reduces serum CstC levels. PMID: 21300820
    10. Data show that the absence of cystatin C reduced epithelial cell apoptosis but increased proliferation in skin. PMID: 21085595
    11. Data show that cystatin C effectively rescues cystatin B loss-of-function mutation, facilitating the reversal of pathophysiological changes and suggesting a novel therapeutic intervention for patients with neurodegenerative disorders. PMID: 20889561
    12. CysC plays a protective role under conditions of neuronal challenge by inducing autophagy via mTOR inhibition PMID: 20352108
    13. Oxidants induce elevated cystatin C production from cardiac myocytes. Cystatin C plays a role in cardiac extracellular matrix remodelling. PMID: 20489058
    14. Data show that cystatin c (CystC) contributes to experimental abdominal aortic aneurysms (AAA) pathogenesis and that lack of CystC favors inflammation in AAA lesions induced in atherosclerotic mice. PMID: 20472891
    15. The embryo's cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S. PMID: 20093401
    16. Cystatin C through this effect can act as an immunomodulatory molecule. PMID: 19446036
    17. expressed in decidual cultures and the expression is controlled in part by TGF-beta(1) and EGF signaling PMID: 11803549
    18. spatiotemporal up-regulation of cystatin C in the hippocampus is induced by entorhinal deafferentation (perforant path transections) PMID: 12044447
    19. Cystatin C is neither necessary nor sufficient to control expression of major histocompatibility type II complexes and antigen presentation in dendritic cells. PMID: 14607896
    20. In vivo overexpression of human cystatin C does not affect amyloid-beta levels in mice that do not deposit amyloid-beta. PMID: 14742906
    21. Data indicate that cystatin C is involved in astrocyte differentiation during mouse brain development. PMID: 15509901
    22. leukocyte-specific expression of cystatin C is actively involved in matrix remodelling associated with atherosclerosis plaque regression. PMID: 15823274
    23. the protective role of cystatin C in atherosclerosis is dependent primarily on its expression in nonhematopoietic cell types PMID: 16051881
    24. PKB activity is a critical downstream component of PDK-1 in mediating translation of cystatin C, RANKL, and Rab11a PMID: 16166629
    25. These data demonstrate that cystatin C has a role in neuronal death and neurogenesis during SE-induced network reorganization. PMID: 16242633
    26. Validity of cystatin C for generating neural stem cells from embryo stem cells in vitro. PMID: 16595632
    27. We propose that in MS, remyelination may be impaired by increasing activity of cathepsins inadequately controlled by cystatin C. PMID: 17086443
    28. Finally, in vivo studies using kidney-specific megalin knockout mice provide evidence that megalin mediates proximal tubular uptake of cystatin C. We conclude that megalin is an endocytic receptor of cystatin C in PTC. PMID: 17462596
    29. These results suggest that CysC affects the BMP signaling cascades in osteoblastic cells and then promotes osteoblast differentiation, mineralization, and bone formation. PMID: 17592728
    30. Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver.( PMID: 18681831
    31. CysC regulates soluble Abeta and Abeta-associated neuronal deficits through inhibiting CatB-induced Abeta degradation. PMID: 18957217

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Cystatin family
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:13010

    STRING: 10090.ENSMUSP00000028938

    UniGene: Mm.4263