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  4. Mouse Endothelial cell-specific molecule 1(ESM1) ELISA kit

Mouse Endothelial cell-specific molecule 1(ESM1) ELISA kit

  • 中文名稱：
    小鼠內(nèi)皮細(xì)胞特異性分子1(ESM1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL007825MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠內(nèi)皮細(xì)胞特異性分子1(ESM1)酶聯(lián)免疫試劑盒（CSB-EL007825MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿,組織勻漿樣本中的ESM1含量。該產(chǎn)品適用于科研領(lǐng)域，可廣泛應(yīng)用于小鼠模型中ESM1表達(dá)的動(dòng)態(tài)監(jiān)測(cè)，例如在腫瘤血管生成研究、動(dòng)脈粥樣硬化模型評(píng)估、炎癥性疾病機(jī)制探索或藥物干預(yù)實(shí)驗(yàn)中定量分析ESM1水平變化，為揭示內(nèi)皮細(xì)胞功能調(diào)控及疾病發(fā)生發(fā)展提供可靠的數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Esm1Endothelial cell-specific molecule 1 ELISA Kit; ESM-1 ELISA Kit
  • 縮寫：
    ESM1
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測(cè)范圍：
    Request Information
  • 靈敏度：
    Request Information
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Tags & Cell Markers
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
  • 基因功能參考文獻(xiàn)：
    1. Data from murine model indicate that NGFR plays an important role in the pathogenesis and progression of oral squamous cell carcinoma via regulation of ESM1. PMID: 27683113
    2. glomerular-derived Esm-1 as a potential non-invasive biomarker of diabetic nephropathy PMID: 28934365
    3. Results reveal a novel pathway for endocan in the control of tumor growth, which involves inflammatory cells of the innate immunity. PMID: 25575808
    4. Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability. PMID: 25057127
    5. This study shows endocan can elicit severe inflammatory responses and inhibiting endocan release offers a potential strategy for treating sepsis. PMID: 24446198
    6. endocan is normally present in the mouse brain and prior vascular perfusion with FITC may provide a useful tool for identify newly forming blood vessels. PMID: 24055127
    7. Mouse endocan serum level was measured at a median of 0.96 ng/mL and 1.08 ng/mL in 129Sv mice and C57bl6, respectively. PMID: 22370430
    8. A paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor. PMID: 20516397
    9. Results suggest that endocan (ESM-1)is preferentially expressed in tumor endothelium in vivo and that its expression is regulated by tumor-derived factors. PMID: 16956626

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  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：