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  4. Mouse Eosinophil Peroxidase (EPO) ELISA Kit

Mouse Eosinophil Peroxidase (EPO) ELISA Kit

  • 中文名稱：
    小鼠嗜酸性粒細(xì)胞過氧化物酶(EPO)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E15830m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠嗜酸性粒細(xì)胞過氧化物酶(EPO)酶聯(lián)免疫試劑盒（CSB-E15830m）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的EPX含量。小鼠嗜酸性粒細(xì)胞過氧化物酶（EPO）是一種調(diào)節(jié)骨代謝的關(guān)鍵酶，通過抑制破骨細(xì)胞和促進(jìn)成骨細(xì)胞功能，維持骨穩(wěn)態(tài)。其作用機(jī)制涉及降低破骨細(xì)胞活性氧水平，抑制RANK-MAPK信號(hào)通路，并可能影響成骨細(xì)胞分化和礦化。試劑盒檢測(cè)范圍為0.156 ng/mL-10 ng/mL，可助力探索嗜酸性粒細(xì)胞介導(dǎo)的免疫反應(yīng)機(jī)制、評(píng)估實(shí)驗(yàn)性炎癥模型中的細(xì)胞活化狀態(tài)，或用于藥物干預(yù)下EPO動(dòng)態(tài)變化的監(jiān)測(cè)，為免疫學(xué)、病理學(xué)及藥理學(xué)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Epx ELISA Kit; Eper ELISA Kit; Eosinophil peroxidase ELISA Kit; EPO ELISA Kit; EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] ELISA Kit
  • 縮寫：
    EPX
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse EPO in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %88
    Range %84-92
    1:2Average %94
    Range %90-98
    1:4Average %99
    Range %95-104
    1:8Average %102
    Range %98-107
  • 回收率：
    The recovery of mouse EPO spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9592-98
    EDTA plasma (n=4)9694-98
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.269 2.298 2.284 2.086
    51.674 1.698 1.686 1.488
    2.51.081 1.098 1.090 0.892
    1.250.729 0.769 0.749 0.551
    0.6250.437 0.457 0.447 0.249
    0.3120.388 0.363 0.376 0.178
    0.1560.283 0.303 0.293 0.095
    00.197 0.198 0.198 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils.
  • 基因功能參考文獻(xiàn)：
    1. The expression of MBP-1 and EPX was also required for induced lung expression of IL-4/IL-13 in each setting and, in turn, the induced pulmonary remodeling events and lung dysfunction. PMID: 28515227
    2. EPO-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma. PMID: 27587397
    3. The absence of MBP-1 and EPX promoted a concomitant loss of eosinophil lineage-committed progenitors in the marrow, identifying a specific blockade in eosinophilopoiesis as the causative event. PMID: 23736699
    4. HER2 was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation. PMID: 21454806
    5. Host protection against Brugia pahangi infections was unimpaired in mice deficient in eosinophil peroxidase. PMID: 16299347
    6. Mice deficient for either eosinophil peroxidase or major basic protein on the 129/SvJ background developed significantly higher worm burdens than wild-type mice. PMID: 16926417
    7. post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase PMID: 18694936
    8. The activities of EPO, an eosinophilic secondary granule protein, do not affect the development of allergic pulmonary pathologies in the mouse lung at levels comparable to those observed in humans with asthma. PMID: 11466391

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  • 亞細(xì)胞定位：
    Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
  • 蛋白家族：
    Peroxidase family, XPO subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:13861

    STRING: 10090.ENSMUSP00000050497

    UniGene: Mm.1315