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  4. Mouse Insulin-like growth factor binding protein 1,IGFBP-1 ELISA Kit

Mouse Insulin-like growth factor binding protein 1,IGFBP-1 ELISA Kit

  • 中文名稱：
    小鼠胰島素樣生長因子結合蛋白1(IGFBP-1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E04587m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠胰島素樣生長因子結合蛋白1(IGFBP-1)酶聯(lián)免疫試劑盒（CSB-E04587m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IGFBP1含量。IGFBP1即胰島素樣生長因子結合蛋白1，它在細胞生長、增殖等過程中起重要作用。其與糖代謝、腫瘤進展等密切相關。研究機制上，主要通過與胰島素樣生長因子結合，調節(jié)其活性與功能，進而影響相關生理和病理過程。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，適用于肥胖、糖尿病等代謝疾病模型研究，或胚胎發(fā)育、肝臟再生等生理病理機制探索；適用于基礎科研中動態(tài)監(jiān)測IGFBP - 1表達水平，為代謝調控、生殖生物學及肝臟相關研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數(shù)及操作步驟詳見產品說明書。
  • 別名：
    Igfbp1 ELISA Kit; Igfbp-1 ELISA Kit; Insulin-like growth factor-binding protein 1 ELISA Kit; IBP-1 ELISA Kit; IGF-binding protein 1 ELISA Kit; IGFBP-1 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse IGFBP-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:100 Average % 89
    Range % 85-94
    1:200 Average % 102
    Range % 96-107
    1:400 Average % 92
    Range % 87-98
    1:800 Average % 94
    Range % 89-98
  • 回收率：
    The recovery of mouse IGFBP-1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 98 93-102
    EDTA plasma (n=4) 103 92-107
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.179 2.234 2.207 2.081
    10 1.816 1.943 1.880 1.754
    5 1.337 1.345 1.341 1.215
    2.5 0.839 0.846 0.843 0.717
    1.25 0.405 0.412 0.409 0.283
    0.625 0.278 0.265 0.272 0.146
    0.312 0.182 0.189 0.186 0.060
    0 0.125 0.126 0.126 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
  • 基因功能參考文獻：
    1. the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss PMID: 26456333
    2. Data suggest expression of Igfbp1 in liver is regulated by dietary factors; carnosine supplementation down-regulates expression of Igfbp1 in liver of obese/diabetic mice; mechanism involves suppression of Hif1a (hypoxia inducible factor 1 alpha). PMID: 25869614
    3. serum IGFBPI protein could provide an easily measured biomarker for early detection of alcohol-induced liver injury in humans PMID: 24152801
    4. These results show that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels. PMID: 22843786
    5. Global deletion of Igfbp1 in a c-Myc transgenic model did not accelerate the development of prostate cancer. Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass. PMID: 21903863
    6. IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals PMID: 12511596
    7. IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBP beta activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways. PMID: 12556485
    8. Induction of IFGBP1 expression by amino acid deprivation of HepG2 hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR. PMID: 15862298
    9. high concentrations of circulating IGFBP-1 are sufficient to cause fetal growth restriction in an animal model PMID: 16293667
    10. the IGFBP-1 gene is a primary target of peroxisome proliferator-activated receptors PMID: 17062566
    11. IGFBP-1 may have an important regulatory role in vivo and in the pathogenesis of type 2 diabetes, in which loss of insulin release is an early pathogenetic event PMID: 17693389
    12. Ahr regulates Igfbp-1 and Lpl expression in the liver. TCDD treatment did not increase the Igfbp-1 and Lpl mRNA levels in Ahr knockout mice. PMID: 18827440
    13. the embryopathic effects are associated with knockdown of EGNL1 and the associated induction of Igfbp1 mRNA in the placenta, but not the embryo. PMID: 19683511

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  • 亞細胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：