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  4. Mouse Insulin-like growth factor binding protein 3,IGFBP-3 ELISA KIT

Mouse Insulin-like growth factor binding protein 3,IGFBP-3 ELISA KIT

  • 中文名稱：
    小鼠胰島素樣生長因子結(jié)合蛋白3(IGFBP-3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E04591m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠胰島素樣生長因子結(jié)合蛋白3(IGFBP-3)酶聯(lián)免疫試劑盒（CSB-E04591m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IGFBP3含量。IGFBP3是一種重要的靶點。它是胰島素樣生長因子結(jié)合蛋白家族成員，與細胞生長、增殖、凋亡等密切相關(guān)。研究發(fā)現(xiàn)其可調(diào)節(jié)胰島素樣生長因子活性，進而影響腫瘤細胞的生物學行為，目前在腫瘤等疾病的發(fā)病機制及治療研究中受廣泛關(guān)注。試劑盒檢測范圍為0.391 ng/mL-25 ng/mL，靈敏度為0.196 ng/mL。本試劑盒適用于小鼠模型在生長發(fā)育研究、代謝性疾?。ㄈ缣悄虿』蚍逝郑C制探索、以及IGF信號通路相關(guān)組織功能分析中的蛋白表達水平檢測。其寬泛的樣本兼容性支持科研人員靈活選擇生物材料，定量結(jié)果可為體內(nèi)外實驗提供可靠數(shù)據(jù)支持，助力于生長因子調(diào)控網(wǎng)絡(luò)的基礎(chǔ)研究。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Igfbp3 ELISA Kit; Igfbp-3 ELISA Kit; Insulin-like growth factor-binding protein 3 ELISA Kit; IBP-3 ELISA Kit; IGF-binding protein 3 ELISA Kit; IGFBP-3 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.391 ng/mL-25 ng/mL
  • 靈敏度：
    0.196 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 最新研究進展：
    IGFBP3是一種結(jié)合胰島素樣生長因子1（IGF1）的蛋白質(zhì)，它在調(diào)節(jié)細胞增殖、凋亡和分化等多種生物學過程中起重要作用。最新的研究顯示，IGFBP3在多種腫瘤中具有潛在的抗腫瘤作用，其具體機制可能涉及調(diào)節(jié)細胞周期、促進細胞凋亡和抑制腫瘤血管生成等方面。此外，IGFBP3還與多種代謝性疾病和心血管疾病的發(fā)病和預后有關(guān)，如2型糖尿病、高血壓、冠心病等。
    近年來，研究人員發(fā)現(xiàn)IGFBP3通過與IgG結(jié)合參與了人體免疫調(diào)節(jié)。一項最新的研究表明，在非小細胞肺癌中，IGFBP3可作為免疫治療的靶點，并且通過與IgG結(jié)合，增強了免疫細胞對腫瘤細胞的殺傷作用，為非小細胞肺癌的免疫治療提供了新的思路。
  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis.
  • 基因功能參考文獻：
    1. Igfbp3-null mouse model was generated in combination with Kras(G12D) to compare the tumor burden. Then, IGF-dependent signaling was assessed after expressing wild-type or a mutant IGFBP3 without IGF binding capacity in non-small cell lung cancer (NSCLC) cells PMID: 28330997
    2. endogenous (circulating and/or stromal) IGFBP-3 is stimulatory to adipose tissue expansion and enhances mammary tumor growth in immune-competent mice, potentially by suppressing T-cell infiltration into tumors. PMID: 27448965
    3. High Igfbp3 expression is associated with skin squamous cell carcinoma. PMID: 28807942
    4. The study shows that the anti-tumoral effect of IGFBP-3 is due to inhibition of the Wnt pathway and depends upon the presence of CD44, a receptor protein known to modulate Wnt signaling. PMID: 27377812
    5. IGFBP-3 influences severity of DSS-induced colitis. PMID: 27253188
    6. our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain PMID: 28088287
    7. IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury. PMID: 26073647
    8. An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage. PMID: 25082650
    9. Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis. PMID: 25614235
    10. Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC migration. PMID: 24358328
    11. IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy. PMID: 22792172
    12. IGFBP-3 activates inhibitory Smad signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFbeta. PMID: 22910030
    13. Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. PMID: 22034491
    14. IGFBP-3 positively and negatively impacts on IGF1-induced lung cancer development. PMID: 21447628
    15. Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3. PMID: 21697095
    16. Mice genetically deficient in IGFBP-3 have weaker growth of primary prostate tumors but higher incidence of metastases. PMID: 21697285
    17. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease. PMID: 21383009
    18. IGFBP-3 has a role in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury PMID: 21435441
    19. The authors showed that expression of insulin-like growth factor binding protein 3 mRNA increases not only in Borna disease virus P-expressing cultured cells but also in astrocytes from the cerebella of P transgenic mice. PMID: 21325425
    20. Association between Igfbp3 and risk of prostatic cancer are examined. PMID: 20473871
    21. This study provides evidence that genetic deletion of IGFBP-3 modulates hepatic carbohydrate and lipid metabolism. PMID: 20926583
    22. Data indicate that impairment of IGF-1 complex formation with insulin-like growth factor binding protein, acid labile subunit in bone marrow alters cell fate, leading to increased adipogenesis. PMID: 20007694
    23. IGFBP3 and Humanin play key roles in the coordinated regulation of testicular germ cell homeostasis. PMID: 19952275
    24. ta indicate that Zik1 and Gja9 demonstrated cancer-specific aberrant DNA methylation, whereas, Cdkn2a/p16, Igfbp3, Mgmt, Id4, and Cxcr4 were methylated in both the AOM tumors and normal colon mucosa. PMID: 19777566
    25. response to nutritional stsatus chanes in PPARalpha knockout mice PMID: 11735249
    26. overexpression of hIGFBP-3 results in fasting hyperglycemia, impaired glucose tolerance, and insulin resistance. PMID: 12376320
    27. IGFBP-3 increases osteoclast number and bone resorption, impairs osteoblast proliferation, and has a significant negative effect on bone formation PMID: 14584894
    28. N- and C-terminal residues of IGFBP-3 have roles in regulating IGF complex formation and receptor activation PMID: 15485880
    29. the growth inhibitory effect of mutant IGFBP-3 may be compensated for by other mechanisms PMID: 15550509
    30. IGFBP-3 induces apoptosis through an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77 PMID: 15731112
    31. Overexpression of Hbegf in transgenic mice downregulates Igfbp3. PMID: 16019424
    32. Igfbp3 modulates cell proliferation in the hair follicle. PMID: 16185287
    33. IGFBP-3 is upregulated by apigenin in a pathway leading to cancer growth inhibition and apoptosis PMID: 16230333
    34. the IGF-independent effects of IGFBP-3 may be important in inhibiting tumor progression PMID: 16469805
    35. IGFBP-3 is a growth inhibitor molecule (news) PMID: 16617154
    36. provide direct evidence for combinatorial effects of IGFBP-3, -4, and -5 in both metabolism and at least some soft tissues PMID: 16675541
    37. IGFBP-3 has direct, IGF-independent inhibitory effects on angiogenesis providing an additional mechanism by which it exerts its tumor suppressive effects PMID: 16983336
    38. IGFBP3 is a downstream gene regulated by MeCP2 and MeCP2 may contribute directly to the transcriptional expression of IGFBP3 in the brain. PMID: 17278996
    39. In summary, the absence of the IGFBP-5 gene did not block the ability of IGF-I to stimulate intestinal growth, possibly because greater jejunal expression of IGFBP-3 compensates for the absence of IGFBP-5. PMID: 17332154
    40. IGFBP-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms PMID: 17388800
    41. Igfbp3 regulates hematopoietic stem cell and endothelial precurosr cell function during vascular development. PMID: 17567755
    42. Igfbp3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. PMID: 17567756
    43. SRC-3 maintains IGF-I in the circulation through enhancing VDR-regulated IGFBP-3 expression. PMID: 18212051
    44. Data suggest that loss of expression of IGFBPs (IGFBP-3 and IGFBP-4) in tumor cells treated with EGFR tyrosine kinase inhibitors derepresses IGFIR signaling, which in turn mediates resistance to EGFR antagonists. PMID: 18568074
    45. IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children. PMID: 18924579
    46. IGFBP-3 inhibits adipocyte differentiation. PMID: 19141684
    47. IGFBP3 is a new regulator of hypocretin cell physiology that may be involved not only in the pathophysiology of narcolepsy, but also in the regulation of sleep in normal individuals, most notably during adolescence PMID: 19158946
    48. IGFBP-3 binds to fibronectin cell binding domain. PMID: 19236847
    49. These studies reveal multisite phosphorylation of IGFBP-3 that both positively and negatively regulate its apoptotic potential. PMID: 19556345
    50. IGFBP-3 mediated chondrocyte apoptosis is regulated by Gli2 and p53 in the progression from benign to malignant cartilage tumors. PMID: 19647223

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  • 亞細胞定位：
    Secreted.
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