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Mouse Insulin-like growth factor-binding protein 5(IGFBP5) ELISA kit

  • 中文名稱:
    小鼠胰島素樣生長因子結(jié)合蛋白5(IGFBP5)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL011099MO
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠胰島素樣生長因子結(jié)合蛋白5(IGFBP5)酶聯(lián)免疫試劑盒(CSB-EL011099MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的IGFBP5含量。IGFBP5是一種重要靶點。它在細(xì)胞生長、增殖、凋亡等過程中發(fā)揮關(guān)鍵作用。研究發(fā)現(xiàn),它可調(diào)節(jié)胰島素樣生長因子活性,進(jìn)而影響多種生理和病理機(jī)制。其異常表達(dá)與腫瘤等疾病的發(fā)生發(fā)展相關(guān),對它的深入研究有助于探索新的治療策略。試劑盒檢測范圍為78 pg/ml-5000pg/ml,靈敏度為19.5 pg/ml。試劑盒適用于生命科學(xué)領(lǐng)域的研究,例如通過檢測不同處理條件下(如基因敲除、藥物干預(yù)或病理模型)的小鼠血清/血漿樣本,分析IGFBP5的動態(tài)變化;也可用于組織勻漿(需離心取上清)的定量分析,探索特定器官或病變組織中IGF信號通路的調(diào)控機(jī)制。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Igfbp5 ELISA Kit; Igfbp-5 ELISA Kit; Insulin-like growth factor-binding protein 5 ELISA Kit; IBP-5 ELISA Kit; IGF-binding protein 5 ELISA Kit; IGFBP-5 ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    78 pg/ml -5000pg/ml
  • 靈敏度:
    19.5 pg/ml
  • 反應(yīng)時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Signal Transduction
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能:
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能參考文獻(xiàn):
    1. Data demonstrate that dysregulation of miR-143-3p:Igfbp5 interactions in satellite cells with age may be responsible for age-related changes in satellite cell function. PMID: 26762731
    2. proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R inhibitors PMID: 26854565
    3. Results from mouse models suggest that inhibiting the up-regulation of IGFBP5 expression in peripheral nerves might prevent or slow down diabetic neuropathy disease progression PMID: 26025657
    4. IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis. PMID: 24551065
    5. indicate that Igf1 was highly expressed in the mesenchyme, Igf2 and Igf1r were expressed in both the midline epithelium and surrounding mesenchyme, and Igfbp5 was highly expressed in the epithelium. PMID: 23584732
    6. investigated the effect of IGFBP5 induction on the progression of liver fibrosis caused by chronic cholangiopathy; expression of IGFBP5 in the Abcb4-/- mice reduces inflammation, oxidative stress, ECM deposition and hepatocyte proliferation, thereby reducing liver fibrosis PMID: 22434064
    7. c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling PMID: 22252554
    8. Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation. PMID: 22117064
    9. Decreased Cav-1 expression in fibrotic diseases likely leads to increased deposition of IGFBP-5 in the extracellular matrix. PMID: 20345844
    10. Data indicate that retinal astrocytes enhance the proliferation of cone-like retinoblastoma cells by deploying IGFBP5, a factor that also provides trophic support to the tumor cells' non-neoplastic counterparts. PMID: 20508032
    11. insulin-like growth factor binding protein 5 is a modulator of tamoxifen resistance in breast cancer PMID: 20354179
    12. Igfbp5 appears to be up-regulated by activation of Akt1 in beta cells or fibroblasts. Knockout studies indicate Igfbp5 may be involved in regulation of metabolism (e.g., glucose intolerance) and growth (i.e., cell size, organ size, and body size). PMID: 19897600
    13. the timing of IGF-II expression and regulation of its accessibility by IGFBP-5 may play a role in anterior pituitary differentiation, survival, and/or proliferation PMID: 11944940
    14. that over-expression of IGFBP-5 can lead to; impaired mammary development, increased expression of the pro-apoptotic molecule caspase-3, increased plasmin generation and decreased expression of pro-survival molecules of the Bcl-2 family PMID: 12223411
    15. IGFBP-5 protein was greatly increased during days 1-3 of mammary gland involution, when levels of apoptosis are dramatically elevated to remodel the gland after lactation PMID: 12538768
    16. Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I PMID: 12626499
    17. IGFBP-5 is a potent growth inhibitor and proapoptotic agent in human breast cancer cells via modulation of cell cycle regulation and apoptotic mediators PMID: 12777377
    18. two of the six serum insulin-like growth factor binding protein-5 quantitative trait loci also showed significant association with total body bone mineral density phenotype PMID: 12865330
    19. By depressing association of IGFs with soluble IGFBPs, Zn(2+) is shown to repartition either [(125)I]-IGF-I or [(125)I]-IGF-II from soluble IGFBP-5 onto cell surface IGF receptors at physiological doses depressing IGF binding to IGFBP-5 and IGF-2R PMID: 14566968
    20. IGFBP-5 acts in myogenesis on IGF-dependent inhibition of differentiation and IGF-independent cell survival. PMID: 15075235
    21. IGFBP-5 has a significant influence on BMD acquisition and maintenance that is dependent on gender and age PMID: 15550514
    22. Femurs from TG mice overexpressing Igbf5 have modest alterations in mineral and matrix distribution. PMID: 15570402
    23. Ectopic expression of Igfbp5 resulted in the appearance of remarkable curvatures and thinning of hair shafts, two hallmarks of hair bends. Both effects and the natural bending process are under negative control of IGF signalling. PMID: 16024235
    24. Data provide support for the hypothesis of dual regulation of IGFBP-5 expression during differentiation and apoptosis in three dimensional cultures of mouse primary epithelial cells. PMID: 16419030
    25. IGFBP5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparin PMID: 16505491
    26. Data show that prolactin is a potent inhibitor, both of cell death, an effect which is suppressed by insulin-like growth factor-binding protein 5 (IGFBP-5), and of matrix metalloproteinase expression, which is independent of the actions of IGFBP-5. PMID: 16720715
    27. Both IGF-I and IGFBP-5 mRNA are the main components of the IGF-I system that are markedly regulated during the osteoblast differentiation of NIH3T3. PMID: 17001448
    28. IGFBP-5, although not essential for normal growth, is required for normal mammary gland involution and can regulate mammary gland morphogenesis in response to hormone stimulation PMID: 17255210
    29. Insulin-like growth factor-binding protein-5 enters vesicular structures but not the nucleus PMID: 17892529
    30. IGFBP5 is a potential regulator of craniofacial skeletogenesis PMID: 18196601
    31. Results show that IGFBP-5 interferes with IGF action in osteoblasts and provides a framework for discerning mechanisms of collaboration between signal transduction pathways activated by BMPs and IGFs in bone. PMID: 18292241
    32. IGFBP-5 binds to fibronectin cell binding domain. PMID: 19236847
    33. Even though wild-type IGFBP-5 severely disrupted the IGF axis, we found no evidence for interaction of mutant IGFBP-5 with the IGF system. PMID: 19332648
    34. Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells. PMID: 11606061

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  • 亞細(xì)胞定位:
    Secreted.
  • 組織特異性:
    Most abundant in kidney, uterus and gastrocnemius muscle.
  • 數(shù)據(jù)庫鏈接: