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  4. Mouse Insulin-like growth factor-binding protein 7(IGFBP7) ELISA kit

Mouse Insulin-like growth factor-binding protein 7(IGFBP7) ELISA kit

  • 中文名稱：
    小鼠胰島素樣生長因子結(jié)合蛋白7(IGFBP7)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011101MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠胰島素樣生長因子結(jié)合蛋白7(IGFBP7)酶聯(lián)免疫試劑盒（CSB-EL011101MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的IGFBP7含量。IGFBP7 是一種重要的靶點。它在細(xì)胞生長、增殖等生理過程中發(fā)揮作用，與腫瘤的發(fā)生發(fā)展密切相關(guān)。研究機制上，主要聚焦其與 IGF 軸的相互作用，以及對細(xì)胞信號通路的調(diào)控等，深入研究有望為相關(guān)疾病治療提供新思路。試劑盒檢測范圍為12.5 pg/mL-800 pg/mL，該產(chǎn)品適用于科研領(lǐng)域?qū)GFBP7的定量研究，例如探索其在疾病模型中的動態(tài)變化、評估藥物干預(yù)效果或解析相關(guān)信號通路機制，為心血管疾病、腫瘤微環(huán)境及組織修復(fù)等基礎(chǔ)研究提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Igfbp7 ELISA Kit; Mac25Insulin-like growth factor-binding protein 7 ELISA Kit; IBP-7 ELISA Kit; IGF-binding protein 7 ELISA Kit; IGFBP-7 ELISA Kit; MAC25 protein ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    12.5 pg/mL-800 pg/mL
  • 靈敏度：
    3.12 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
  • 基因功能參考文獻：
    1. Our findings define an immune component of the pleiotropic mechanisms through which IGFBP7 suppresses hepatocellular carcinoma PMID: 28619711
    2. Study shows that IGFBP7 contributes significantly to mesenchymal stromal cells (MSC)-mediated immune modulation, as is shown by decreasing ability of IGFBP7 knockdown in MSCs to restore proliferation and cytokine production in T-cells. PMID: 27397633
    3. data suggest that IGFBP-7 was up regulated during EAE and inhibit the transition from OPCs to mature OLs, implying its use as a potential therapeutic target for the treatment of inflammatory demyelinating diseases PMID: 25819415
    4. Our data suggest that loss of Igfbp7 induces precocious involution possibly through diminished cell survival signals. PMID: 24505323
    5. Angiomodulin is necessary for cardiac commitment of embryonic stem cells (ESCs) and its regulation depends on TAp63 isoform. PMID: 24145187
    6. a model whereby IGFBP7 binds to unoccupied IGF1R and suppresses downstream signaling, thereby inhibiting protein synthesis, cell growth, and survival. PMID: 23250396
    7. IGFBP7 has a novel role in mouse uterus: it is regulating uterine receptivity through Th1/Th2 lymphocyte balance and decidualization. PMID: 23028860
    8. fear extinction-induced IGF2/IGFBP7 signalling promotes the survival of 17-19-day-old newborn hippocampal neurons PMID: 21873981
    9. Results demonstrate that the vascular-specific marker angiomodulin (AGM) modulates vascular remodeling in part by temporizing the proangiogenic effects of VEGF-A. PMID: 19542015
    10. study showed that IGFBP-rP1 (IGFBP7) was expressed in dysregulated podocytes in a human immunodeficiency virus-associated nephropathy model and in immature podocytes in the developing kidney; conclude that IGFBP-rP1 may be a product of injured podocytes PMID: 20630940
    11. Mac25 interacts with the extracellular matrix proteins and glycosaminoglycans that are expressed in most blood vessels including high endothelial venules, as well as with chemokines implicated in regulation of lymphocyte trafficking, e.g., SLC and IP-10. PMID: 12847218
    12. Proteolytic processing of mac25 modulates its insulin/IGF-1-dependent growth-stimulatory activity. PMID: 14521955
    13. IGFBP-7 can regulate glioma cell migration through the AKT-ERK pathway, thereby playing an important role in glioma growth and migration PMID: 19048112

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  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Expressed at high levels in lung, kidney, small intestine, testis and uterus and at moderate levels in liver.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:29817

    UniGene: Mm.233470