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  4. Mouse Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

Mouse Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

  • 中文名稱：
    小鼠白介素-22受體α-2亞基(IL22RA2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011637MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠白介素-22受體α-2亞基(IL22RA2)酶聯(lián)免疫試劑盒（CSB-EL011637MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL22RA2含量。IL22RA2是一個靶點。它是白細胞介素 22 的受體亞基，在免疫調節(jié)等生理過程中可能發(fā)揮重要作用。相關研究或聚焦其與疾病發(fā)生發(fā)展關聯(lián)機制，如免疫失衡、炎癥反應等，探索以此為靶點開發(fā)治療藥物或干預手段。試劑盒檢測范圍為46.88 pg/mL-3000 pg/mL，可為科研人員探究IL22RA2在免疫調節(jié)機制、炎癥性疾病模型或腫瘤發(fā)生發(fā)展中的動態(tài)變化提供可靠工具；適用于基礎研究中對體液或組織樣本的蛋白表達水平監(jiān)測，為探索相關疾病的分子機制提供數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Il22ra2Interleukin-22 receptor subunit alpha-2 ELISA Kit; IL-22 receptor subunit alpha-2 ELISA Kit; IL-22R-alpha-2 ELISA Kit; IL-22RA2 ELISA Kit; Cytokine receptor family type 2 ELISA Kit; soluble 1 ELISA Kit; CRF2-S1 ELISA Kit; Interleukin-22-binding protein ELISA Kit; IL-22BP ELISA Kit; IL22BP ELISA Kit; ZcytoR16 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    46.88 pg/mL-3000 pg/mL
  • 靈敏度：
    11.7 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL22RA2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %94
    Range %90-97
    1:2Average %100
    Range %95-103
    1:4Average %95
    Range %89-100
    1:8Average %89
    Range %84-92
  • 回收率：
    The recovery of mouse IL22RA2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9590-97
    EDTA plasma (n=4)9591-98
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    30002.412 2.423 2.418 2.258
    15001.812 1.776 1.794 1.634
    7501.116 1.078 1.097 0.937
    3750.705 0.688 0.697 0.537
    187.50.434 0.459 0.447 0.287
    93.750.322 0.314 0.318 0.158
    46.880.256 0.243 0.250 0.090
    00.162 0.158 0.160 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
  • 基因功能參考文獻：
    1. limits the pathological manifestations in models of allergic contact dermatitis and psoriasis PMID: 27676439
    2. Il22bp-deficient mice were more susceptible to acute liver damage in models of acute liver damage induced by ischemia reperfusion and acetaminophen administration. IL-22BP plays a protective role in acute liver damage, via controlling IL-22-induced Cxcl10 expression. PMID: 29109123
    3. IL-22BP promotes bacterial uptake into Peyer's patches by influencing follicle-associated epithelium gene expression and function. PMID: 28512157
    4. IL22RA2 KO displayed a less severe EAE course, less demyelination and less infiltration of immune cells in the CNS. PMID: 25008863
    5. the IL-22-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon PMID: 23075849
    6. cloning and characterization; gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 binding protein; upregulated by LPS stimulation in monocytes PMID: 12700595

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Type II cytokine receptor family
  • 組織特異性：
    Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart.
  • 數(shù)據(jù)庫鏈接：