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  4. Mouse Interleukin-34(IL34) ELISA kit

Mouse Interleukin-34(IL34) ELISA kit

  • 中文名稱：
    小鼠白介素-34(IL34)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL011657MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠白介素-34(IL34)酶聯(lián)免疫試劑盒（CSB-EL011657MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的IL34含量。IL34是一種重要靶點(diǎn)。它是細(xì)胞因子，能與CSF - 1R等受體結(jié)合參與多種生理過程。在研究機(jī)制上，其在免疫調(diào)節(jié)、腫瘤微環(huán)境調(diào)控等方面受關(guān)注，探索其作用機(jī)制有助于揭示疾病發(fā)病機(jī)理，為相關(guān)疾病治療提供新方向。試劑盒檢測(cè)范圍為1.56 pg/mL-100 pg/mL，適用于探索IL-34在免疫調(diào)節(jié)機(jī)制、疾病動(dòng)物模型中的表達(dá)變化，或用于評(píng)估藥物干預(yù)對(duì)IL-34分泌水平的影響本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Il34Interleukin-34 ELISA Kit; IL-34 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    1.56 pg/mL-100 pg/mL
  • 靈敏度：
    0.39 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
  • 基因功能參考文獻(xiàn)：
    1. The current study aimed to assess the IL-34 expression in response to two members of the transforming growth factor (TGF)-beta family, TGF-beta1 and bone morphogenetic protein (BMP)-2, in synovial fibroblasts from rheumatoid arthritis patients. PMID: 27865758
    2. study concludes that Langerhans cells require IL-34 when residing in fully differentiated and anatomically intact skin epidermis, but rely on neutrophil-derived CSF1 during inflammation PMID: 26634935
    3. constitutive IL-34 expressed by skin keratinocytes might suppress resident macrophage responses to C. albicans colonisation by maintaining low levels TLR2 and Dectin-1 expression by macrophages. PMID: 26146640
    4. IL-34 protected blood-brain barrier integrity by restored expression levels of tight junction proteins, which were downregulated by pro-inflammatory cytokines. PMID: 25535736
    5. IL-34-dependent, Mo-mediated, CSF-1 nonredundant mechanisms promote persistent ischemia-incited AKI that worsens subsequent CKD. PMID: 26121749
    6. In vitro and in vivo experiments indicate that IL-34 expression is regulated by TNF-a and IL-1b and that its overexpression is associated with an increase in osteosarcoma growth and metastasis. PMID: 25471534
    7. the expression pattern of IL-34 in ileum and colon and suggest IL-34 as a new modulator of inflammation in inflammatory bowel disease PMID: 25896238
    8. Tumor necrosis factor-alpha induces IL-34 expression via NF-kappaB in MC3T3-E1 osteoblastic cells. PMID: 24970360
    9. These findings suggest that TGF-beta produced by IL-34-treated microglia is a negative regulator of microglial proliferation and enhances the neuroprotective property of microglia. PMID: 22985514
    10. Differentiated signaling between IL-34 and CSF-1 is likely achieved by the relative thermodynamic independence of IL-34 versus negative cooperativity of CSF-1 at the CSF-1 receptor recognition sites. PMID: 22579672
    11. IL-34 as a nonredundant cytokine for the development of Langerhans cells during embryogenesis as well as for their homeostasis in the adult skin. PMID: 23177320
    12. IL-34 specifically directs the differentiation of myeloid cells in the skin epidermis and central nervous system. PMID: 22729249
    13. Postnatal neocortical expression showed that CSF-1 was expressed in layer VI, whereas IL-34 was expressed in the meninges and layers II-V. The broader expression of IL-34 is consistent with its previously implicated role in microglial development. PMID: 22542597
    14. The function of Interleukin-34 (IL-34), a newly discovered cytokine, on microglia was examined. PMID: 21872563
    15. This study was to explore the biological function, specifically osteoclastogenesis and bone metabolism, of il-34. PMID: 21494622
    16. The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues. PMID: 20504948

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-34 family
  • 數(shù)據(jù)庫鏈接：