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  4. Mouse Interleukin-36 alpha(IL1F6) ELISA kit

Mouse Interleukin-36 alpha(IL1F6) ELISA kit

  • 中文名稱：
    小鼠白介素36α(IL1F6)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL011617MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠白介素36α(IL1F6)酶聯(lián)免疫試劑盒（CSB-EL011617MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的Il36a含量。Il36a是一個(gè)靶點(diǎn)。它在免疫系統(tǒng)中可能發(fā)揮一定作用。相關(guān)研究機(jī)制可能聚焦于其在免疫信號(hào)傳導(dǎo)通路里的功能，探索它與炎癥、疾病發(fā)生發(fā)展的關(guān)聯(lián)，以明確其在免疫調(diào)節(jié)中的具體角色，為開發(fā)針對性治療方法提供依據(jù)。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，可支持科研人員在炎癥機(jī)制研究、藥物干預(yù)效果評估或基因編輯模型驗(yàn)證中定量分析IL - 36α的動(dòng)態(tài)變化，尤其適用于免疫代謝研究、感染性疾病模型或組織微環(huán)境分析等實(shí)驗(yàn)場景，為探索IL - 36α在先天免疫與適應(yīng)性免疫中的調(diào)控網(wǎng)絡(luò)提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Il36a ELISA Kit; Fil1e ELISA Kit; Il1e ELISA Kit; Il1f6 ELISA Kit; Il1h1Interleukin-36 alpha ELISA Kit; FIL1 epsilon ELISA Kit; Interleukin-1 epsilon ELISA Kit; IL-1 epsilon ELISA Kit; Interleukin-1 family member 6 ELISA Kit; IL-1F6 ELISA Kit; Interleukin-1 homolog 1 ELISA Kit; IL-1H1 ELISA Kit
  • 縮寫：
    IL1F6
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL1F6 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 90  
    Range % 85-90  
    1:2 Average % 89  
    Range % 84-95  
    1:4 Average % 99  
    Range % 95-104  
    1:8 Average % 93  
    Range % 85-99  
  • 回收率：
    The recovery of mouse IL1F6 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 96 90-107  
    EDTA plasma (n=4) 88 80-96  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    1000 2.591 2.587 2.589 2.486  
    500 2.017 2.046 2.032 1.929  
    250 1.365 1.389 1.377 1.274  
    125 0.799 0.751 0.775 0.672  
    62.5 0.455 0.483 0.469 0.366  
    31.2 0.261 0.243 0.252 0.149  
    15.6 0.169 0.186 0.178 0.075  
    0 0.102 0.104 0.103 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces NF-kappa B activation in macrophages.
  • 基因功能參考文獻(xiàn)：
    1. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344
    2. IL-1 and IL-36 have roles as inflammatory mediators in pustular psoriasis in a mouse model PMID: 28057979
    3. IL-1alpha and IL-36alpha form a self-amplifying inflammatory loop in vivo that in patients with insufficient counter regulatory mechanisms may become hyper-engaged and/or chronic PMID: 26203636
    4. An essential role of C/EBPbeta in the regulation of the Il36A gene via the proximal half-CRE*C/EBP element in response to inflammatory stimuli. PMID: 26066982
    5. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin PMID: 24829417
    6. IL-36alpha acts as a pro-inflammatory cytokine in the lungs independent of both IL-1alpha and IL-1beta. PMID: 23029241
    7. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity PMID: 21965679
    8. A critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses. PMID: 21860022
    9. Transcripts for IL-1F5, -1F6, -1F8, and -1F9 are all significantly increased in the involved skin of bitransgenic mice compared with their monotransgenic controls. PMID: 21242515
    10. local overexpression related to the development of tubulointerstitial lesions PMID: 20101239
    11. IL-1F6 can be externalized via a stimulus-coupled mechanism comparable to that used by IL-1beta PMID: 19717513

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  • 亞細(xì)胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 組織特異性：
    Highly expressed in embryonic tissue and in tissues containing epithelial cells. Elevated expression levels are detected in chronic kidney disease; expressed inepithelia from the distal convoluted tubules (DCTs) to the cortical collecting ducts (CCDs) in
  • 數(shù)據(jù)庫鏈接：