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  4. Mouse Interleukin-36 beta(IL1F8) ELISA kit

Mouse Interleukin-36 beta(IL1F8) ELISA kit

  • 中文名稱：
    小鼠白介素36β(IL1F8)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011619MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠白介素36β(IL1F8)酶聯(lián)免疫試劑盒（CSB-EL011619MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL1F8含量。IL1F8是一個靶點。它屬于IL-1家族成員，在免疫調(diào)節(jié)等過程發(fā)揮作用。研究機制方面，其參與多種信號通路調(diào)控，可能與炎癥相關疾病的發(fā)生發(fā)展有關，目前針對它的研究有助于揭示疾病發(fā)病機制并為開發(fā)新療法提供方向。試劑盒檢測范圍為6.25 pg/mL-400 pg/mL，炎癥性疾病動物模型的病理機制探索、藥物干預后免疫因子動態(tài)監(jiān)測、基因編輯小鼠的免疫功能評估、免疫調(diào)節(jié)、皮膚炎癥及自身免疫性疾病的基礎研究本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Il36b ELISA Kit; Fil1e ELISA Kit; Il1f8 ELISA Kit; Interleukin-36 beta ELISA Kit; Interleukin-1 family member 8 ELISA Kit; IL-1F8 ELISA Kit
  • 縮寫：
    IL1F8
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T-helper 1 (Th1) cells, cultured CD4(+) T-cells and splenocytes.
  • 基因功能參考文獻：
    1. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin PMID: 24829417
    2. Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity PMID: 21965679
    3. A critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses. PMID: 21860022
    4. The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce any of the classical IL-1 responses in glial cells. PMID: 15749024
  • 亞細胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 數(shù)據(jù)庫鏈接：