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  4. Mouse Keratinocyte Growth Factor(KGF/FGF-7) ELISA Kit

Mouse Keratinocyte Growth Factor(KGF/FGF-7) ELISA Kit

  • 中文名稱：
    小鼠角化細胞生長因子(KGF/FGF-7)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13046m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠角化細胞生長因子(KGF/FGF-7)酶聯(lián)免疫試劑盒（CSB-E13046m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的FGF7含量。FGF7，即成纖維細胞生長因子7，是一種上皮細胞特異性生長因子，主要參與組織發(fā)育、修復(fù)和維持。其研究機制涉及與FGFR2b受體結(jié)合，調(diào)節(jié)細胞增殖、分化和存活，并在多種生理過程中發(fā)揮關(guān)鍵作用。試劑盒檢測范圍為1.56 pg/mL-100 pg/mL，該產(chǎn)品可廣泛應(yīng)用于上皮細胞生物學(xué)、組織再生機制、傷口愈合模型等基礎(chǔ)研究領(lǐng)域，也可用于評估藥物干預(yù)或基因修飾對KGF表達水平的影響。對于細胞實驗，可直接檢測培養(yǎng)上清中分泌型KGF的濃度；針對動物模型，支持從血清、血漿或特定組織勻漿中定量分析內(nèi)源性KGF的表達動態(tài)，為皮膚、肺、腸道等上皮組織相關(guān)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Fgf7 ELISA Kit; Fgf-7 ELISA Kit; Kgf ELISA Kit; Fibroblast growth factor 7 ELISA Kit; FGF-7 ELISA Kit; Heparin-binding growth factor 7 ELISA Kit; HBGF-7 ELISA Kit; Keratinocyte growth factor ELISA Kit; KGF ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    1.56 pg/mL-100 pg/mL
  • 靈敏度：
    0.39 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse KGF in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:100Average %94
    Range %89-98
    1:200Average %96
    Range %91-102
    1:400Average %90
    Range %85-96
    1:800Average %94
    Range %85-105
  • 回收率：
    The recovery of mouse KGF spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9185-96
    EDTA plasma (n=4)10095-103
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    1002.513 2.569 2.541 2.349
    502.163 2.168 2.166 1.974
    251.633 1.658 1.646 1.454
    12.50.992 0.999 0.996 0.804
    6.250.562 0.571 0.567 0.375
    3.120.368 0.383 0.376 0.184
    1.560.272 0.291 0.282 0.090
    00.190 0.193 0.192 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
  • 基因功能參考文獻：
    1. Tregs express kgf. Treg-specific expression of kgf regulates alveolar epithelial proliferation during the resolution phase of acute lung injury and in a model of regenerative alveologenesis in vivo. AT2 cells cocultured with Tregs lacking kgf have decreased rates of proliferation. PMID: 28296468
    2. A role for endogenous KGF in maintenance of normal pulmonary innate immune function. PMID: 26919897
    3. Suppression of miR-219-5p may benefit the liver regeneration and prevent cirrhosis through increasing KGF. PMID: 27855391
    4. we examine how the two presynaptic organizers FGF22 and FGF7 are transported to the appropriate locations so that they act as synapse-type-specific organizing molecules. PMID: 25431136
    5. Exendin-4 increased fibroblast growth factor 7 (Fgf7) expression in colonic polyps of Apc(Min/+) mice. PMID: 25738454
    6. Our observations also point towards PI3K acting as a morphogenic switch for FGF7 signalling. PMID: 25460003
    7. Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments. PMID: 24227310
    8. IL-19 is important for cutaneous wound healing because it upregulates KGF expression. PMID: 23582717
    9. FGF7 is downregulated in MED1-deficient mesenchymal cells. FGF7 produced by mesenchymal stromal cells is a novel hematopoietic niche molecule. PMID: 24051090
    10. KGF pretreatment could improve radiation-induced intestinal injury including the epithelial structure and function in a mouse model, as shown by Zo-1 protein and Claudin-1. PMID: 23464848
    11. KGF could up-regulate IL-7 expression through the STAT1/IRF-1, IRF-2 signaling pathway, which is a new insight in potential effects of KGF on the intestinal mucosal immune system. PMID: 23554911
    12. Fibroblast growth factor 7 (Fgf7) was identified as a target of miR-143 in murine adipogenesis. PMID: 23247565
    13. FGF7 is a critical regulator of liver progenitor cells PMID: 23322300
    14. Given the specifically targeted effects of FGF-7 on epithelial cells, the authors' findings suggest that further FGF-7-dependent epithelial-mesenchymal interaction exists that may be important in diabetic wound healing. PMID: 22094769
    15. Keratinocyte growth factor gene transduction ameliorates pulmonary fibrosis induced by bleomycin in mice PMID: 21131445
    16. These results suggest that KGF may play an important role in the regulation of VEGF gene expression and angiogenesis during wound healing. PMID: 21672345
    17. KGF promotes preadipocyte proliferation by an autocrine mechanism that involves activation of the PI3K/Akt signaling pathway PMID: 20069574
    18. two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers PMID: 20505669
    19. keratinocyte growth factor works via an inducible lentivirus to protect bone marrow cells against bleomycin-induced pulmonary fibrosis PMID: 19956603
    20. Protection from thymic epithelial cell injury by keratinocyte growth factor PMID: 12036893
    21. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. PMID: 12091365
    22. Following activation by KGF binding, KGF and the KGF receptor remain associated in active complexes through the endocytic pathway, which is described. PMID: 12122441
    23. Stress-induced alterations in cutaneous proinflammatory cytokine and growth factor expression are associated with significant histological changes in healing wounds. PMID: 12161023
    24. gammadelta cell-deficient mice (TCRdelta(-/-)) and KGF-deficient mice (KGF(-/-)) were more prone than wild-type mice to DSS-induced mucosal injury and demonstrated delayed tissue repair after termination of DSS treatment PMID: 12376619
    25. PAK4 interacts with KGF receptor and mediate anti-apoptosis effects of KGF on epithelial cells. PMID: 12529371
    26. In a mouse model of total parenteral nutrition (TPN), application of KGF to TPN mice reversed the decline of proliferation of EC during TPN and prevented the increase in EC apoptosis with TPN alone. PMID: 12592627
    27. KGF-induced Akt activation may play an important role in inhibiting lung alveolar cell death thereby preserving the lung architecture and function during oxidative stress PMID: 12732722
    28. BMP4 and FGF7/FGF10 arrest early T-cell development at the CD4-CD8-CD44+CD25- (double-negative 1 [DN1]) population and at the CD4-CD8- double-negative to CD4+CD8+ double-positive transition in a stromal compartment-dependent manner PMID: 12920023
    29. Structure-based mutational analyses in FGF7 identify new residues involved in specific interaction with FGFR2IIIb. PMID: 14527678
    30. KGF from gamma delta-T cell receptor-expressing intraepithelial lymphocytes is an important factor for maintenance of intestinal epithelial cell proliferation and villus growth. PMID: 15034027
    31. Biological activity of FGF-7 in RAG-1 mice indicates that immuno-dependent mechanisms are not required for the induction of urothelial cell proliferation by this growth factor. PMID: 15176316
    32. epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling is coordinated by sprouty proteins during kidney development, which regulates ureteric branching PMID: 15201220
    33. KGF antibody abolished the growth promoting effect of GLP-2 in the large intestine, but not in the small intestine PMID: 15544847
    34. KGF appears to be an important growth factor for local resident progenitor epithelial cell repair PMID: 17332441
    35. FGF7 improved survival during acute lung injury in adult mouse lung after short-term expression, but paradoxically induced inflammation and injury after persistent expression. PMID: 17994369
    36. Krt12-rtTA/tet-O-FGF-7 mice may be a suitable animal model for the study of the molecular and cellular mechanisms of human ocular surface squamous neoplasia. PMID: 18276784
    37. Ectopic expression of KGF in acinar cells promotes the expansion of the beta-cell lineage in vivo through activation of the PKB/Akt pathway. PMID: 18372394
    38. p63/p51-induced onset of keratinocyte differentiation via the c-Jun N-terminal kinase pathway is counteracted by keratinocyte growth factor PMID: 18849344
    39. Fgf7 protects against acute lung injury PMID: 17994369

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 數(shù)據(jù)庫鏈接：