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  4. Mouse Neurogranin(NRGN) ELISA kit

Mouse Neurogranin(NRGN) ELISA kit

  • 中文名稱(chēng)：
    小鼠神經(jīng)顆粒素(NRGN)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL016081MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠神經(jīng)顆粒素(NRGN)酶聯(lián)免疫試劑盒（CSB-EL016081MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的NRGN含量。NRGN（神經(jīng)顆粒素）是一種神經(jīng)元特異性的蛋白質(zhì)，由位于11q24.2染色體上的基因編碼。它在突觸信號(hào)傳導(dǎo)中起重要作用，通過(guò)調(diào)節(jié)鈣調(diào)蛋白（CaM）的可用性來(lái)影響突觸可塑性和學(xué)習(xí)記憶。NRGN的表達(dá)與精神分裂癥、甲狀腺功能減退癥和阿爾茨海默病等疾病有關(guān)。研究顯示，NRGN通過(guò)鈣調(diào)蛋白依賴(lài)性調(diào)節(jié)神經(jīng)元磷酸化蛋白質(zhì)組，雙向調(diào)節(jié)突觸可塑性，對(duì)認(rèn)知功能有重要影響。試劑盒檢測(cè)范圍為3.12 ng/mL-200 ng/mL，適用于神經(jīng)發(fā)育、神經(jīng)退行性疾病模型（如阿爾茨海默病或帕金森病）以及突觸功能相關(guān)的分子機(jī)制研究，能夠?yàn)樘剿髡J(rèn)知功能障礙、藥物干預(yù)效果等科研方向提供定量數(shù)據(jù)支持。支持科研人員高效完成神經(jīng)科學(xué)領(lǐng)域的蛋白表達(dá)水平分析。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    NrgnNeurogranin ELISA Kit; Ng ELISA Kit; RC3) [Cleaved into: NEUG(55-78)] ELISA Kit
  • 縮寫(xiě)：
    NRGN
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    3.12 ng/mL-200 ng/mL
  • 靈敏度：
    0.78 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning.
  • 基因功能參考文獻(xiàn)：
    1. The findings of this study specifically suggest that accumbal Ng plays an essential role in the counterbalance between NMDAR and mGluR5 signaling. PMID: 29225043
    2. The results of this study indicated that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks. PMID: 25972176
    3. Neurogranin knockout mice are hyperactive and socially withdrawn. PMID: 22809330
    4. Ng expression in olfactory bulb is restricted to developmental stages suggesting activity-dependent regulation in a time window critical for glomerular circuit development, suggesting a role for Ng in maturation and dendritic remodeling of tufted cells. PMID: 22592880
    5. findings suggest that mobilization of CaM and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2+ transients and activation of Ca2+/CaM-dependent enzymes. PMID: 21256930
    6. We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 loci will increase the diversity of posttranscriptional regulation PMID: 20693275
    7. Results provide a new specific neurochemical marker to identify a subpopulation of olfactory granule cells and suggest possible functional implications for neurogranin in olfactory bulb plasticity mechanisms. PMID: 19827160
    8. Data show that Ng displays a strong nuclear localization when expressed in cell lines and hippocampal neurons. PMID: 19751214
    9. Attenuation of protein kinase C and cAMP-dependent protein kinase signal transduction in the neurogranin knockout mouse PMID: 11912190
    10. Neurogranin expression in the cerebellum by brush cells, which are excitatory, shows remarkable cell type- and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms. PMID: 12655510
    11. calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3 PMID: 12859333
    12. NMDA induced a rapid and transient phosphorylation and oxidation of neurogranin in mouse hippocampal slices PMID: 12950461
    13. NG is expressed by principal cells in different neocortical layers and in the hippocampus by granule cells of the dentate gyrus and pyramidal neurons of CA1-CA3. PMID: 15389613
    14. Results suggest that neurogranin oxidation plays a significant role in intracellular calcium homeostasis, essential for the activated signaling networks in learning and memory. PMID: 15469893
    15. Ng may promote a high [Ca2+]i by a "mass-action" mechanism; namely, the higher the Ng concentration, the more Ng-CaM complexes will be formed. PMID: 15564582
    16. These results suggest that neurogranin protein may be involved in the development of cerebral hypoxic preconditioning. PMID: 16182446
    17. Data suggest that parasagittal stripes of Purkinje cells express neurogranin, possibly from as early as embryonic day (E) 13 and definitively from E15, in a pattern that persists up to postnatal day 20. PMID: 16320235
    18. Neurogranin(Ng) gates neuronal signaling reactions involved in learning and memory. During environmental enrichment, these Ng-regulated reactions are also critical for enhancement of synaptic plasticity and cognitive functions. PMID: 16763030
    19. Recombinant mNg promotes SNP-induced cell death in human cells through an amplification of calcium-mediated signaling, which requires the interaction between CaM and IQ motif of Ng. PMID: 17389928
    20. phosphorylation of neurogranin (Ng) but not the calmodulin/Ng interaction plays an important role in ERK activation PMID: 17505539
    21. long-term enrichment for the aging Ng-/- mice may improve their cognitive function through an Ng-independent plasticity pathway PMID: 17671107
    22. Neurogranin may regulate, in addition to the Ca(2+)-CaM-dependent process, Ca(2+)-sensitive enzymes by influencing the buffering capacity of CaM and subsequently free Ca(2+) levels. PMID: 17959737
    23. The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice. PMID: 19376211

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine.
  • 蛋白家族：
    Neurogranin family
  • 數(shù)據(jù)庫(kù)鏈接：