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  4. Mouse Neurturin(NRTN) ELISA kit

Mouse Neurturin(NRTN) ELISA kit

  • 中文名稱：
    小鼠神經(jīng)秩蛋白(NRTN)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL016095MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠神經(jīng)秩蛋白(NRTN)酶聯(lián)免疫試劑盒（CSB-EL016095MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的NRTN含量。小鼠神經(jīng)秩蛋白(NRTN)是一種神經(jīng)營(yíng)養(yǎng)因子，屬于GDNF家族，對(duì)神經(jīng)元生存和功能調(diào)節(jié)起重要作用。其研究機(jī)制涉及通過(guò)GFRα/RET受體復(fù)合體激活cAMP/PKA途徑促進(jìn)上皮細(xì)胞增殖，并參與調(diào)節(jié)神經(jīng)生長(zhǎng)和穩(wěn)定性。試劑盒檢測(cè)范圍為31.25 pg/mL-2000 pg/mL，該產(chǎn)品適用于神經(jīng)科學(xué)研究領(lǐng)域，可應(yīng)用于神經(jīng)疾病動(dòng)物模型構(gòu)建、藥物干預(yù)效果評(píng)估、神經(jīng)發(fā)育調(diào)控機(jī)制探索等實(shí)驗(yàn)場(chǎng)景，為體外定量分析NRTN蛋白表達(dá)提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Nrtn ELISA Kit; Neurturin ELISA Kit
  • 縮寫：
    NRTN
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse NRTN in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %85
    Range %81-89
    1:2Average %94
    Range %90-98
    1:4Average %83
    Range %80-86
    1:8Average %97
    Range %94-101
  • 回收率：
    The recovery of mouse NRTN spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10297-105
    EDTA plasma (n=4)8985-93
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    20002.310 2.368 2.339 2.157
    10001.510 1.630 1.570 1.388
    5000.885 0.875 0.880 0.698
    2500.500 0.531 0.516 0.334
    1250.368 0.378 0.373 0.191
    62.50.308 0.301 0.305 0.123
    31.250.240 0.250 0.245 0.063
    00.181 0.183 0.182
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
  • 基因功能參考文獻(xiàn)：
    1. These results indicate that NRTN contributes to an increase in the epidermal density of nonpeptidergic nerves in the imiquimod-induced psoriasis model, and this increase may be a factor in chronic itch. PMID: 28825602
    2. NRTN causes presynaptic and postsynaptic restoration of the nigrostriatal dopaminergic system after a 6-OHDA-induced chronic lesion. PMID: 29176874
    3. identified IFNg, Neurturin (Nrtn), and glial-derived neurotrophic factor (GDNF) as ligands with unexpected roles in promoting neurogenic differentiation of Neural Precursor Cells in vivo. PMID: 27545711
    4. These results demonstrate the potential roles of different functional groups of sensory neurons in the behavioral changes observed in mice overexpressing cutaneous neurturin and highlight the importance of neurturin in regulating cutaneous afferent response properties. PMID: 28031403
    5. Deletion of neurturin impairs cholinergic innervation of the heart and the baroreflex response in early postnatal development. PMID: 27162260
    6. Our findings support the hypothesis that NTN could modulate the allergic inflammation in different mouse asthma models. PMID: 25595789
    7. NTN inactivation enhances androgen sensitivity in reproductive and neuroendocrine tissues. PMID: 23678134
    8. the expression level of NRTN in the skin modulates gene expression in cutaneous sensory afferents and behavioral sensitivity to thermal, chemical, and mechanical stimuli. PMID: 23365243
    9. Findings provide evidence for a dampening role of NTN on allergic inflammation and AHR in a murine model of asthma. PMID: 21508262
    10. Transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons. PMID: 12433948
    11. This study revealed the complexity of postnatal maturation of urogenital innervation, with each organ showing a distinct chronology of innervation and different requirement for neurturin. PMID: 18175352
    12. Neurturin-mediated Ret signaling is critical to normal retinal development and function. PMID: 18417692
    13. TGF-beta with neurturin and persephin are required for the induction of dopaminergic neurons, whereas GDNF is required for regulating and/or maintaining a differentiated neuronal phenotype PMID: 18420832
    14. Report structural and functional cardiac cholinergic deficits in adult neurturin knockout mice. PMID: 19176599

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family, GDNF subfamily
  • 組織特異性：
    Widespread distribution.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:18188

    STRING: 10090.ENSMUSP00000046512

    UniGene: Mm.8074