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  4. Mouse Osteoclast-associated immunoglobulin-like receptor(OSCAR) ELISA kit

Mouse Osteoclast-associated immunoglobulin-like receptor(OSCAR) ELISA kit

  • 中文名稱：
    小鼠破骨細(xì)胞相關(guān)免疫球蛋白樣受體(OSCAR)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL017255MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠破骨細(xì)胞相關(guān)免疫球蛋白樣受體(OSCAR)酶聯(lián)免疫試劑盒（CSB-EL017255MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的OSCAR含量。小鼠破骨細(xì)胞相關(guān)免疫球蛋白樣受體(OSCAR)在破骨細(xì)胞形成和免疫調(diào)節(jié)中起關(guān)鍵作用，能促進(jìn)破骨細(xì)胞形成及存活，并參與免疫細(xì)胞的激活和成熟，是骨重建和免疫治療的重要靶點(diǎn)。試劑盒檢測(cè)范圍為37.5 pg/mL-2400 pg/mL，支持科研人員開展骨代謝調(diào)控機(jī)制、骨質(zhì)疏松模型評(píng)估、骨免疫相關(guān)藥物開發(fā)等基礎(chǔ)研究，為體外實(shí)驗(yàn)提供可靠的定量數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Oscar ELISA Kit; Osteoclast-associated immunoglobulin-like receptor ELISA Kit; Osteoclast-associated receptor ELISA Kit; mOSCAR ELISA Kit; Ocl178 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    37.5 pg/mL-2400 pg/mL
  • 靈敏度：
    9.375 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse OSCAR in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:5 Average % 89  
    Range % 82-93  
    1:10 Average % 105  
    Range % 97-108  
    1:20 Average % 93  
    Range % 88-97  
    1:40 Average % 95  
    Range % 91-98  
  • 回收率：
    The recovery of mouse OSCAR spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 94 89-97  
    EDTA plasma (n=4) 91 85-94  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    2400 2.885 2.877 2.881 2.761  
    1200 2.068 2.089 2.079 1.959  
    600 1.152 1.123 1.138 1.018  
    300 0.689 0.687 0.688 0.568  
    150 0.398 0.391 0.395 0.275  
    75 0.301 0.289 0.295 0.175  
    37.5 0.210 0.222 0.216 0.096  
    0 0.119 0.121 0.120    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
  • 基因功能參考文獻(xiàn)：
    1. OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis PMID: 23817038
    2. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID: 21841309
    3. PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade. PMID: 12695521
    4. the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation PMID: 15184345
    5. analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts PMID: 16109714
    6. Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis. PMID: 18762192

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family
  • 組織特異性：
    Specifically expressed in preosteoclasts or mature osteoclasts.
  • 數(shù)據(jù)庫(kù)鏈接：