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  4. Mouse Protein Wnt-7b(WNT7B) ELISA kit

Mouse Protein Wnt-7b(WNT7B) ELISA kit

  • 中文名稱：
    小鼠Wnt-7b蛋白(WNT7B)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL026142MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠Wnt-7b蛋白(WNT7B)酶聯(lián)免疫試劑盒（CSB-EL026142MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的WNT7B含量。WNT7B 是一種重要的靶點(diǎn)。它屬于 WNT 蛋白家族成員，在細(xì)胞生長(zhǎng)、分化、組織穩(wěn)態(tài)維持等多種生理過(guò)程中起關(guān)鍵作用。研究機(jī)制主要圍繞其參與 WNT 信號(hào)通路，異常激活或抑制該通路與多種疾病如腫瘤的發(fā)生發(fā)展密切相關(guān)。試劑盒檢測(cè)范圍為0.312 ng/mL-20 ng/mL，可廣泛應(yīng)用于發(fā)育生物學(xué)、疾病機(jī)制研究及藥物開(kāi)發(fā)等科研領(lǐng)域，例如探究Wnt - 7b在特定組織中的表達(dá)調(diào)控、評(píng)估基因編輯或藥物干預(yù)對(duì)信號(hào)通路的影響等。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Wnt7b ELISA Kit; Wnt-7b ELISA Kit; Protein Wnt-7b ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Stem Cells
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse WNT7B in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %93
    Range %85-105
    1:2Average %89
    Range %84-96
    1:4Average %95
    Range %90-100
    1:8Average %95
    Range %87-101
  • 回收率：
    The recovery of mouse WNT7B spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9793-101
    EDTA plasma (n=4)9489-99
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    202.580 2.618 2.599 2.447
    101.532 1.482 1.507 1.355
    50.933 0.895 0.914 0.762
    2.50.579 0.586 0.583 0.431
    1.250.352 0.346 0.349 0.197
    0.6250.258 0.269 0.264 0.112
    0.3120.207 0.213 0.210 0.058
    00.155 0.149 0.152
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation.
  • 基因功能參考文獻(xiàn)：
    1. Ptgs2 inhibitor celecoxib reduces dsRNA-induced WIHN and Wnt7b, and exogenous prostaglandin E2 can rescue WIHN and Wnt7b. Although other Wnts and pathways likely contribute, these results highlight noncoding dsRNA as an upstream coordinator of prostaglandin and Wnt levels in regeneration. PMID: 28392344
    2. In a mouse model of myopia, there was downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia. PMID: 25823570
    3. Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development. PMID: 25576928
    4. Transgenic Wnt7b overexpression in neural progenitor cells impairs neuronal differentiation and the development of forebrain structures at embryonic day 10.5. It decreased expression of Tbr1 and Tbr2, in both progenitor cells and post-mitotic neurons. PMID: 24953933
    5. These findings demonstrate the importance of intrinsic Wnt7b expression in hfSCs regulation and normal HF cycling PMID: 24222445
    6. Stable ectopic expression of Wnt-7b in OSCC cells overexpressing miR329 or miR410 restored proliferation and invasion capabilities abolished by these miRNA PMID: 25351956
    7. Results illustrated the critical role of myeloid WNT7B in tumor progression, acting at the levels of angiogenesis, invasion, and metastasis. PMID: 24638982
    8. Thus, WNT7B promotes bone formation in part through mTORC1 activation. PMID: 24497849
    9. Wnt7b preserves endothelial phenotype in aortic endothelial cells. PMID: 23685555
    10. Epithelial Wnt7b and Wnt9b as possible ligands of Fzd1-mediated beta-catenin (Ctnnb1)-dependent (canonical) Wnt signaling in the undifferentiated ureteric mesenchyme. PMID: 22833126
    11. Dkk1 controls the degree of Wnt-7b signalling in the papilla to coordinate kidney organogenesis. PMID: 21354128
    12. Because Wnt7b is known to stimulate epithelial responses during kidney development, these findings suggest that macrophages are able to rapidly invade an injured tissue and reestablish a developmental program that is beneficial for repair and regeneration PMID: 20160075
    13. promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium PMID: 11914369
    14. Wnt7b signaling is required for proper lung mesenchymal growth and vascular development PMID: 12361974
    15. Data demonstrate that Wnt7b signals through Fzd1 and -10 and LRP5 and implicate these Wnt coreceptors in the regulation of lung airway and vascular development. PMID: 15923619
    16. macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye PMID: 16163358
    17. Wnt7b signals to neighboring cells to activate both autocrine and paracrine canonical Wnt signaling cascades. In contrast to results from hypomorphic models, Wnt7b modulates several important signaling pathways in the lung. PMID: 18367557
    18. These findings demonstrate that Wnt7b is a key regulator of the tissue architecture that establishes a functional physiologically active mammalian kidney. PMID: 19060336
    19. alpha3beta1 integrin, a major laminin receptor, and c-Met, the receptor for hepatocyte growth factor, signal coordinately to regulate the expression of Wnt7b in the papilla of the developing kidney PMID: 19176588
    20. Wnt7b regulates a program of mesenchymal differentiation in the lung that is essential for SMC development. PMID: 19690384

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  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix. Secreted.
  • 蛋白家族：
    Wnt family
  • 數(shù)據(jù)庫(kù)鏈接：