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  4. Mouse R-spondin-4(RSPO4) ELISA kit

Mouse R-spondin-4(RSPO4) ELISA kit

  • 中文名稱(chēng)：
    小鼠R脊椎蛋白4(RSPO4)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL020553MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠R脊椎蛋白4(RSPO4)酶聯(lián)免疫試劑盒（CSB-EL020553MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的RSPO4含量。RSPO4是重要靶點(diǎn)。它在胚胎發(fā)育、組織穩(wěn)態(tài)維持等過(guò)程起關(guān)鍵作用。研究發(fā)現(xiàn)其通過(guò)與特定受體結(jié)合激活Wnt信號(hào)通路，影響細(xì)胞增殖與分化。在疾病方面，RSPO4異常表達(dá)和信號(hào)失調(diào)與腫瘤、皮膚病等發(fā)病機(jī)制相關(guān)。試劑盒檢測(cè)范圍為34.4 pg/mL-2200 pg/mL，適用于體外研究RSPO4在疾病模型中的動(dòng)態(tài)變化，如基因編輯小鼠的蛋白表達(dá)驗(yàn)證、病理狀態(tài)下信號(hào)通路的分子機(jī)制探索，或藥物干預(yù)后生物標(biāo)志物的定量評(píng)估，為發(fā)育生物學(xué)、腫瘤學(xué)及代謝研究領(lǐng)域提供可靠的實(shí)驗(yàn)工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Rspo4R-spondin-4 ELISA kit; Cysteine-rich and single thrombospondin domain-containing protein 4 ELISA kit; Cristin-4 ELISA kit; mCristin-4 ELISA kit; Roof plate-specific spondin-4 ELISA kit
  • 縮寫(xiě)：
    RSPO4
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    34.4 pg/mL-2200 pg/mL
  • 靈敏度：
    8.6 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Developmental Biology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse RSPO4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 91
    Range % 87-95
    1:2 Average % 97
    Range % 93-102
    1:4 Average % 92
    Range % 85-96
    1:8 Average % 97
    Range % 95-101
  • 回收率：
    The recovery of mouse RSPO4 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 96 92-101
    EDTA plasma (n=4) 87 83-93
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2200 2.452 2.371 2.412 2.280
    1100 1.956 1.815 1.886 1.754
    550 1.208 1.182 1.195 1.063
    275 0.717 0.701 0.709 0.577
    137.5 0.425 0.413 0.419 0.287
    68.75 0.292 0.288 0.290 0.158
    34.4 0.196 0.192 0.194 0.062
    0 0.132 0.131 0.132 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway.
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    R-spondin family
  • 數(shù)據(jù)庫(kù)鏈接：