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  4. Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit

Mouse Scavenger receptor cysteine-rich type 1 protein M130(CD163) ELISA kit

  • 中文名稱：
    小鼠清道夫受體富含半胱氨酸1蛋白M130(CD163)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004882MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠清道夫受體富含半胱氨酸1蛋白M130(CD163)酶聯(lián)免疫試劑盒（CSB-EL004882MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CD163含量。CD163是一種清道夫受體，主要在單核-巨噬細(xì)胞膜上表達(dá)，具有清除血紅蛋白-觸珠蛋白復(fù)合物的功能。它既是巨噬細(xì)胞活化的標(biāo)志物，也具有抗炎、抗氧化作用，與腫瘤、肝衰竭等疾病的發(fā)生發(fā)展密切相關(guān)。試劑盒檢測范圍為0.93 ng/ml-60ng/ml，靈敏度為0.23 ng/ml。適用于炎癥模型研究、免疫調(diào)控機(jī)制探索、血液相關(guān)疾病動物實(shí)驗(yàn)等科研場景，能夠有效評估巨噬細(xì)胞活化狀態(tài)或病理?xiàng)l件下CD163的動態(tài)變化，為心血管疾病、代謝綜合征及感染性疾病的基礎(chǔ)研究提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cd163 ELISA kit; M130Scavenger receptor cysteine-rich type 1 protein M130 ELISA kit; CD antigen CD163) [Cleaved into: Soluble CD163 ELISA kit; sCD163)] ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.9 ng/ml-60 ng/ml
  • 靈敏度：
    0.23 ng/ml
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse CD163 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    97

    Range %

    91-103

    1:2

    Average %

    87

    Range %

    80-96

    1:4

    Average %

    87

    Range %

    84-91

    1:8

    Average %

    95

    Range %

    91-99

  • 回收率：

    The recovery of mouse CD163 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    88

    82-95

    EDTA plasma (n=4)

    92

    87-96

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    60

    2.306

    2.233

    2.270

    2.206

    30

    1.356

    1.275

    1.316

    1.252

    15

    0.742

    0.752

    0.747

    0.683

    7.5

    0.481

    0.491

    0.486

    0.422

    3.75

    0.264

    0.275

    0.270

    0.206

    1.8

    0.207

    0.205

    0.206

    0.142

    0.9

    0.105

    0.100

    0.103

    0.039

    0

    0.063

    0.065

    0.064

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    CD163是一種單核細(xì)胞的受體，可參與調(diào)節(jié)細(xì)胞的炎癥和免疫反應(yīng)。最新研究表明，CD163在多種疾病的發(fā)生發(fā)展中起重要作用，如肝病、炎癥性腸病、肺炎、骨質(zhì)疏松等。此外，CD163還可能成為腫瘤治療的新靶點(diǎn)，相關(guān)研究正在進(jìn)行中。
  • 功能：
    Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.; After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
  • 基因功能參考文獻(xiàn)：
    1. house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia PMID: 26376364
    2. In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes. PMID: 27354410
    3. During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch signalling necessary for myogenic progenitor cell proliferation. PMID: 26242746
    4. Data indicate an essential substrate motif for ADAM17-mediated CD163 and proTNF-alpha cleavage in macrophages. PMID: 24275664
    5. alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress. PMID: 22807450
    6. Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209. PMID: 21427223
    7. Assignment of the CD163 antigen to mouse chromosome 6 band F2. PMID: 12698011

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  • 亞細(xì)胞定位：
    [Soluble CD163]: Secreted.; Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen and mesenteric lymph nodes.
  • 數(shù)據(jù)庫鏈接：