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  4. Mouse Secretoglobin family 3A member 1(SCGB3A1) ELISA kit

Mouse Secretoglobin family 3A member 1(SCGB3A1) ELISA kit

  • 中文名稱：
    小鼠分泌球蛋白家族3A成員1(SCGB3A1)酶聯免疫試劑盒
  • 貨號：
    CSB-EL020818MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    小鼠分泌球蛋白家族3A成員1(SCGB3A1)酶聯免疫試劑盒（CSB-EL020818MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SCGB3A1含量。SCGB3A1是呼吸道上皮分泌蛋白，在肺組織等有表達。其與肺部疾病如肺纖維化、肺癌等密切相關。研究機制上，它參與調節(jié)肺部炎癥反應、細胞增殖與分化，有望作為生物標志物用于疾病診斷及治療靶點開發(fā)。試劑盒檢測范圍為62.5 pg/ml-4000 pg/ml，適用于科研領域中小鼠肺部疾病模型、氣道炎癥機制研究、基因修飾動物模型的表型驗證等場景，為探索SCGB3A1在呼吸系統(tǒng)病理生理過程中的功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Scgb3a1 ELISA Kit; Hin1 ELISA Kit; Pnsp2 ELISA Kit; Ugrp2 ELISA Kit; Secretoglobin family 3A member 1 ELISA Kit; Cytokine HIN-1 ELISA Kit; High in normal 1 ELISA Kit; Pneumo secretory protein 2 ELISA Kit; PnSP-2 ELISA Kit; Uteroglobin-related protein 2 ELISA Kit
  • 縮寫：
    SCGB3A1
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    62.5 pg/ml -4000 pg/ml
  • 靈敏度：
    15.6 pg/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Secreted cytokine-like protein. Inhibits cell growth in vitro.
  • 基因功能參考文獻：
    1. Neonatal hyperoxia followed by RA recovery was associated with decreased lung CCSP and SCGB3A1 protein but not mRNA expression. PMID: 24187664
    2. The differential expression of mRNA by both airway level and lung region was determined for uteroglobin-related protein 2. PMID: 20852037
    3. Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands PMID: 12175512
    4. genomic structure and expression patterns of Ugrp2 and its alternative spliced form were characterized PMID: 12438750
    5. EGF-induced increase of Ugrp2 occurred at the transcriptional level that required the EGF receptor and the activation of the ERK-MAPK and phosphoinositide-3 kinase pathways PMID: 15811345
    6. ubiquitous transcription factor NF-Y binds to and activates expression of the Scgb3a1 gene and tissue-specific expression of the gene is associated with CpG methylation of the promoter PMID: 18194566
    7. The expression of SCGB3A1 and SCGB3A2 are bidirectionally regulated by oncostatin M (OSM) when examined in a mouse transformed Clara cell line. PMID: 18978304
    8. Expression of SCGB3A1 was down-regulated by IFN-gamma in a time- and dose-dependent manner in the murine transformed Clara Cells line. PMID: 19135978

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family, UGRP subfamily
  • 組織特異性：
    Highly expressed in lung, where it localizes to epithelial cells lining the trachea and bronchi. Expression in lung is mainly restricted to bronchi, submucosal glands of the trachea, and tracheal epithelium, with little expression in terminal bronchioles.
  • 數據庫鏈接：