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  4. Mouse Thrombospondin-2(THBS2) ELISA kit

Mouse Thrombospondin-2(THBS2) ELISA kit

  • 中文名稱(chēng)：
    小鼠血小板反應(yīng)蛋白-2(THBS2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL023488MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠血小板反應(yīng)蛋白-2(THBS2)酶聯(lián)免疫試劑盒（CSB-EL023488MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿.樣本中的THBS2含量。THBS2是一個(gè)靶點(diǎn)。目前雖未給出其背景具體信息，但作為研究靶點(diǎn)，科學(xué)家可能?chē)@它探索其在生物體內(nèi)的作用機(jī)制，如與疾病發(fā)生、發(fā)展的關(guān)聯(lián)，在細(xì)胞信號(hào)傳導(dǎo)、增殖分化等過(guò)程中扮演的角色，以尋找潛在治療策略。試劑盒檢測(cè)范圍為6.25 ng/ml-400 ng/ml.，靈敏度為1.56 ng/ml.?？蒲腥藛T可將其應(yīng)用于心血管疾病模型、腫瘤微環(huán)境研究或組織修復(fù)機(jī)制探索等基礎(chǔ)研究領(lǐng)域，通過(guò)檢測(cè)不同病理狀態(tài)下THBS2的表達(dá)動(dòng)態(tài)，為相關(guān)分子機(jī)制解析提供數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Thbs2 ELISA Kit; Tsp2 ELISA Kit; Thrombospondin-2 ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates.
  • 檢測(cè)范圍：
    6.25 ng/ml-400 ng/ml.
  • 靈敏度：
    1.56 ng/ml.
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse THBS2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    96

    Range %

    90-103

    1:2

    Average %

    102

    Range %

    97-106

    1:4

    Average %

    89

    Range %

    86-93

    1:8

    Average %

    94

    Range %

    89-98

  • 回收率：

    The recovery of mouse THBS2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    103

    98-107

    EDTA plasma (n=4)

    95

    90-111

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    400

    2.366

    2.454

    2.410

    2.230

    200

    1.523

    1.633

    1.578

    1.398

    100

    0.974

    0.958

    0.966

    0.786

    50

    0.603

    0.632

    0.618

    0.438

    25

    0.421

    0.425

    0.423

    0.243

    12.5

    0.298

    0.286

    0.292

    0.112

    6.25

    0.233

    0.250

    0.242

    0.062

    0

    0.179

    0.180

    0.180

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    THBS2是一種血小板的富含蛋白質(zhì)，已知在多個(gè)生物過(guò)程中起到重要的作用。最近的研究表明，THBS2在多種癌癥的發(fā)展中發(fā)揮著作用，例如胃癌、乳腺癌、肺癌等。研究表明，THBS2與腫瘤的侵襲、轉(zhuǎn)移和血管新生有關(guān)。
  • 功能：
    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
  • 基因功能參考文獻(xiàn)：
    1. Data provide evidence that TSP2 transcription is suppressed by hypoxia through a mechanism that requires HIF-1alpha. PMID: 28789925
    2. TWIST2 induces miR-221-3p expression and consequently suppresses its direct target, THBS2, in lymphatic metastasis cervical cancer. PMID: 29242498
    3. TSP2 deficiency imparted a brittle phenotype on cortical bone. electron microscopy revealed less intensely stained collagen fibrils with altered morphology in the extracellular matrix assembled by osteoblasts on the anterior surface of TSP2-KO femora. PMID: 26272319
    4. Enhanced levels of TSP-2 in the skin result in reduced susceptibility to chemically-induced skin carcinogenesis. PMID: 24507936
    5. in the context of osteoblast differentiation, TSP2 promotes the assembly of a type-I collagen-rich matrix by facilitating pro-collagen processing. PMID: 23763373
    6. The proposed mechanism for the shift in stem cell fate in fracture healing is that increased vascular density and hence oxygen availability in TSP2-null mice regulates differentiation. PMID: 23775935
    7. The upregulation of TSP-2 mediated by increased oxidative stress contributes to angiogenesis dysfunction in diabetic bone marrow derived angiogenic cells. PMID: 23723366
    8. TSP2 is a negative regulator of ischemic fracture healing, and in the absence of TSP2 bone regeneration is enhanced. PMID: 23280580
    9. Using a TSP-2-knockout mouse model and cardiac cell transplantation, we found significantly reduced fibrosis and increased endothelial cell density in the peri-graft region. PMID: 22512900
    10. the two TSP2 isforms are differentially modulated at injured and noninjured skeletal sites in an animal undergoing fracture healing. PMID: 22362307
    11. TSP-2 has a protective role against cardiac inflammation, injury, and dysfunction in acute viral myocarditis. PMID: 22308237
    12. astrocyte-derived TSP-2 is critical for the maintenance of physiological MMP-2 and MMP-9 levels during the foreign body response and contributes to the repair of the BBB PMID: 21704005
    13. Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2 PMID: 21949402
    14. The secreted protein is an autocrine inhibitor of marrow stromal cell proliferation. PMID: 11874233
    15. Megakaryocytes require this protein for normal platelet formation and function. PMID: 12732502
    16. Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling PMID: 12861025
    17. TSP2-null mice provide an animal model to assist in the understanding of the molecular basis of spontaneous, premature softening of the uterine cervix. PMID: 14561659
    18. Delay in expression of TSP2 and metalloproteinase 2 in the wounds of aged mice could contribute to their impaired rate of wound healing. PMID: 14996433
    19. CD36 mediates the antiangiogenic effect of thrombospondin-2, which is modulated by histidine-rich glycoprotein PMID: 15748999
    20. the absence of TSP2 protects against ovariectomy-induced bone loss by two complementary processes: increased formation and decreased resorption. PMID: 15979292
    21. Mutations targeting intermodular interfaces or calcium binding destabilize the thrombospondin-2 signature domain. PMID: 18682400
    22. TSP-2 was found to be present in some, but not all, annulus cells of the human annulus and the mouse annulus. PMID: 18718009
    23. Taken together, our observations support a role for TSP2 as critical determinant of the brain response to biomaterials. PMID: 19020342
    24. TSP-2 expression in the heart protects against age-dependent dilated cardiomyopathy. PMID: 19805649

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  • 蛋白家族：
    Thrombospondin family
  • 數(shù)據(jù)庫(kù)鏈接：