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  4. Mouse protein C (PC) ELISA kit

Mouse protein C (PC) ELISA kit

  • 中文名稱：
    小鼠蛋白C(PC)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E13585m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠蛋白C(PC)酶聯(lián)免疫試劑盒（CSB-E13585m）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的PROC含量。試劑盒檢測范圍為1.25 ng/ml-80 ng/ml，支持科研領(lǐng)域?qū)π∈竽Ｐ椭心δ墚惓５臋C(jī)制研究，例如血栓性疾病、遺傳性蛋白C缺乏癥等動(dòng)物模型的病理分析，也可用于藥物干預(yù)或基因修飾后凝血系統(tǒng)變化的動(dòng)態(tài)監(jiān)測，為心血管及血液系統(tǒng)研究提供穩(wěn)定可靠的工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Proc ELISA Kit; Vitamin K-dependent protein C ELISA Kit; EC 3.4.21.69 ELISA Kit; Anticoagulant protein C ELISA Kit; Autoprothrombin IIA ELISA Kit; Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide] ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    1.25 ng/ml-80 ng/ml
  • 靈敏度：
    0.625 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
  • 基因功能參考文獻(xiàn)：
    1. Data show that activated protein C signals via protease activated receptors PAR2/PAR3 to expand Treg cells, mitigating the disease in mice. PMID: 28827518
    2. APC modifies pulmonary fibrosis by limiting thrombin-dependent macrophage recruitment. PMID: 27295971
    3. Small interfering RNA-mediated silencing of protein C in apolipoprotein E-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis. PMID: 28302625
    4. These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC in the context of endotoxemia and infection PMID: 26341257
    5. activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow. PMID: 26457757
    6. impaired EPCR/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis PMID: 26045607
    7. SOD prevents thrombomodulin methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice. PMID: 26069236
    8. sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation. PMID: 25069533
    9. Data identify anticoagulant activated protein C as a "metaplastic molecule", capable of shifting the threshold of LTP towards further potentiation PMID: 24753100
    10. Histones regulate activated protein C formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis. PMID: 24177324
    11. EPCR and APC play a limited role in the host response during pulmonary tuberculosis. PMID: 23348224
    12. Inhibition of the anticoagulant function of activated protein C does not interfere with its protective role during Gram-negative pneumosepsis, suggesting a more prominent role for cytoprotective effects of APC . PMID: 23216621
    13. RNA interference of Serpinc1 and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis. PMID: 23550037
    14. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. PMID: 23267072
    15. Polyphosphate can elicit potent pro-inflammatory responses through the activation of NF-kappaB, which are counteracted by activated protein C. PMID: 22372856
    16. The aPC mechanism of action is complex, involving induction of Treg differentiation, inhibition of inflammation, and possibly direct cyto-protective effects on beta cells. PMID: 22447930
    17. We conclude that activated protein C generation and function can be modulated by changes in phospholipid occupancy of its endothelial cell receptor. PMID: 22167755
    18. Findings show that the protein C (PC) pathway is a unique system involved in controlling intestinal homeostasis and inflammation by regulating epithelial barrier function. PMID: 22109555
    19. Endogenous PC has strong effects on the host response to lethal influenza A infection, inhibiting pulmonary coagulopathy and inflammation on the one hand, but facilitating neutrophil influx and protein leak and accelerating mortality on the other hand. PMID: 21330465
    20. Endogenous protein C inhibits activation of coagulation and transiently lowers bacterial outgrowth in murine Escherichia coli peritonitis PMID: 21251201
    21. endogenous APC is essential for immune-mediated cancer cell elimination PMID: 21420234
    22. Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. PMID: 20348393
    23. endogenous acute coagulopathy is mediated by the activation of the protein C pathway PMID: 19333141
    24. These findings show a new function for the thrombomodulin-protein C system in controlling the growth and survival of trophoblast cells in the placenta, which is essential for the maintenance of pregnancy. PMID: 12579195
    25. surviving Thrombomodulin pro/pro mice displayed increased lung inflammation accompanied by higher mycobacterial loads in liver and spleen PMID: 16014564
    26. directly links host endogenous levels of PC with various coagulation, inflammation, and hemodynamic end points following a severe acute inflammatory challenge PMID: 17047151
    27. in the presence of a limited level of the anticoagulant, PC, placental homeostasis can be restored by reducing TF expression, thus facilitating proper embryonic implantation PMID: 18647222
    28. species specificity in the effects of pregnancy on the major determinants of the protein C system; Pregnancy causes a decrease in APC resistance in mice, which can be explained by the elevation of protein S levels and increased TFPI activity in plasma. PMID: 19036061
    29. An important role for the aPC/EPCR pathway in reducing metastasis via inhibition of tumor cell adhesion and transmigration. PMID: 19188668
    30. Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1. PMID: 19350118
    31. activated PC is barrier-protective in ventilator lung injury and endothelial PC receptor is a critical participant in APC-mediated protection PMID: 19363121

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  • 亞細(xì)胞定位：
    Secreted. Golgi apparatus. Endoplasmic reticulum.
  • 蛋白家族：
    Peptidase S1 family
  • 組織特異性：
    Plasma; synthesized in the liver.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:19123

    STRING: 10090.ENSMUSP00000132226

    UniGene: Mm.2786