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  4. Mouse Transforming growth factor-beta-induced protein ig-h3(TGFBI) ELISA kit

Mouse Transforming growth factor-beta-induced protein ig-h3(TGFBI) ELISA kit

  • 中文名稱：
    小鼠轉(zhuǎn)化生長因子β誘導(dǎo)蛋白 ig-h3(TGFBI)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL023450MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠轉(zhuǎn)化生長因子β誘導(dǎo)蛋白 ig-h3(TGFBI)酶聯(lián)免疫試劑盒（CSB-EL023450MO）檢測樣本中的TGFBI含量。TGFBI是一個值得關(guān)注的靶點。它在細(xì)胞生長、黏附等過程中發(fā)揮作用，與多種疾病如腫瘤、眼部疾病等相關(guān)。研究機制涉及調(diào)控細(xì)胞外基質(zhì)，影響細(xì)胞的遷移、增殖與凋亡，對其深入研究有助于開發(fā)針對相關(guān)疾病的治療策略?？捎糜诳蒲蓄I(lǐng)域中小鼠疾病模型（如纖維化、腫瘤或角膜病變）的機制研究、基因表達(dá)調(diào)控分析或藥物干預(yù)實驗中的生物標(biāo)志物檢測，為探索TGFBI在相關(guān)信號通路中的功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    TgfbiTransforming growth factor-beta-induced protein ig-h3 ELISA kit; Beta ig-h3 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 檢測范圍：
    Request Information
  • 靈敏度：
    Request Information
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in cell adhesion. May play a role in cell-collagen interactions.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that big-h3 protein (BIGH3) acts as a tumor suppressor in the retina. PMID: 28099942
    2. findings demonstrate a novel role of lithium in the inhibition of colon cancer metastasis by blocking TGFBIp expression, and thereby TGFBIp-induced lymphangiogenesis, in primary tumors. PMID: 26857144
    3. TGF-beta-induced matricellular protein-null lungs displayed diminished elastic recoil and gas exchange efficiency PMID: 26878215
    4. Vicenin-2 and scolymoside could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway. PMID: 26084452
    5. the data suggest a model by which cytokine-induced Myt3 suppression leads to Tgfbi de-repression and subsequently to impaired islet-cell migration, revealing a novel role for Myt3 in regulating islet-cell migration. PMID: 26177052
    6. Studies reveal that growth hormone (GH)increases TGFBI expression in a mouse and rat models of diabetic nephropathy (DN) which correlate with clinical results, and suggest that this mechanism can explain the podocytes depletion in DN. PMID: 25740786
    7. Tgfbi deficiency is associated with the degradation of cartilage matrix PMID: 25450762
    8. The results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFbeta released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis. PMID: 25378215
    9. TGFBI is a potential risk gene for human diabetes. PMID: 24728038
    10. High blood TGFBIp levels were observed in cecal ligation and puncture (CLP)-induced septic mice. The absence of the TGFBIp gene in mice attenuated CLP-induced sepsis. PMID: 24506343
    11. Collectively, our findings indicate that betaig-h3 promotes the fibrogenic influence of TGFbeta signaling, neutralizing the prochondrogenic influence of the hypoxic-inducible factor 1 activated by the microenvironment of limb mesenchymal aggregates. PMID: 22924741
    12. the observed effect of TGFBI on bone mass and bone size was largely caused by the effect of TGFBI on periosteal bone formation PMID: 22644324
    13. betaig-h3 bears alphavbeta3 integrin-interacting motifs that mediate endothelial cell adhesion and migration and angiogenesis PMID: 12704192
    14. The spatiotemporal distribution of Beta-ig during various stages of murine development was examined and its ability to support adhesion of various cell types assessed PMID: 12963107
    15. During pregnancy, high levels of betaig-h3 mRNA were detected in the uterus on Day 4 of gestation, when the trophoblastic invasion of the implanted blastocysts was very active. PMID: 14967934
    16. Recombinant beta ig-h3 and its FAS1 domain significantly inhibit in vitro osteoblast differentiation as evaluated by matrix mineralization/bone nodule formation. PMID: 15780949
    17. analysis of mouse fasciclin-containing genes (betaigH3, periostin, stabilin-1, and stabilin-2) expression patterns during valvuloseptal morphogenesis PMID: 15907457
    18. keratoepithelin may help to build up a bridge between collagen VI and yet unidentified muscle receptor PMID: 18249103
    19. Betaig-h3 may play a critical role as a regulator of chondrogenic differentiation in endochondral ossification. PMID: 18779658
    20. Blocking of betaig-h3 expression in E12.5 embryos with antisense oligodeoxynucleotides resulted in cleft of the secondary palate PMID: 19415673

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  • 亞細(xì)胞定位：
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 組織特異性：
    Expressed in heart, kidney, liver, skeletal muscle, testis, thyroid and uterus.
  • 數(shù)據(jù)庫鏈接：