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  4. Mouse Transforming growth factor beta receptor type 3(TGFBR3) ELISA kit

Mouse Transforming growth factor beta receptor type 3(TGFBR3) ELISA kit

  • 中文名稱：
    小鼠轉(zhuǎn)化生長(zhǎng)因子β受體3(TGFBR3)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL023453MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠轉(zhuǎn)化生長(zhǎng)因子β受體3(TGFBR3)酶聯(lián)免疫試劑盒（CSB-EL023453MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的TGFBR3含量。TGFBR3 是重要的轉(zhuǎn)化生長(zhǎng)因子-β 超家族輔助受體。其與腫瘤、心血管等疾病的發(fā)生發(fā)展密切相關(guān)。研究機(jī)制上，它參與細(xì)胞生長(zhǎng)、分化和遷移等多種信號(hào)通路的調(diào)控，通過影響細(xì)胞生物學(xué)行為發(fā)揮作用，是藥物研發(fā)和疾病治療的潛在靶點(diǎn)。試劑盒檢測(cè)范圍為6.25 pg/mL-400 pg/mL，適用于細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)研究、疾病模型構(gòu)建及分子機(jī)制探索等科研場(chǎng)景，為探索 TGF-β信號(hào)通路調(diào)控機(jī)制提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Tgfbr3 ELISA Kit; Transforming growth factor beta receptor type 3 ELISA Kit; TGF-beta receptor type 3 ELISA Kit; TGFR-3 ELISA Kit; Betaglycan ELISA Kit; Transforming growth factor beta receptor III ELISA Kit; TGF-beta receptor type III ELISA Kit
  • 縮寫：
    TGFBR3
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測(cè)范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse TGFBR3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 102
    Range % 96-107
    1:2 Average % 92
    Range % 86-97
    1:4 Average % 97
    Range % 93-102
    1:8 Average % 87
    Range % 81-92
  • 回收率：
    The recovery of mouse TGFBR3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 98 94-102
    EDTA plasma (n=4) 89 84-95
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    400 2.754 2.874 2.814 2.602
    200 2.332 2.444 2.388 2.176
    100 1.823 1.778 1.801 1.589
    50 1.156 1.134 1.145 0.933
    25 0.624 0.605 0.615 0.403
    12.5 0.423 0.411 0.417 0.205
    6.25 0.318 0.314 0.316 0.104
    0 0.212 0.211 0.212 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
  • 基因功能參考文獻(xiàn)：
    1. TGFbetaR3 promotes apoptosis of cardiomyocytes via a p38 pathway-associated mechanism, and loss of TGFbetaR3 reduces myocardial infarction injury. PMID: 28559372
    2. describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells PMID: 29050936
    3. Study identified a novel major binding site for TGF-beta-like growth factors in TGFR-3. Findings potentially provide novel experimental insight into the general function of zona pellucida domain-containing proteins. PMID: 23826237
    4. a signaling pathway important in epicardial cell behavior downstream of TGFbetaR3 PMID: 27505173
    5. Retinoic acid enhanced TbetaRIII expression and that this increase contributed to LF-stimulated IgA production. PMID: 26277894
    6. These data reveal a critical, previously unrecognized role for TGFbetaR3 in vascular and osteoblast development during palatogenesis. PMID: 25382630
    7. These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells. PMID: 25077702
    8. TGFBR3 mediated suppression of cancer progression includes effects on the tumor immune microenvironment. PMID: 23925295
    9. Loss of Tgfbr3 compromises the functions of TGFbeta2 in the differentiating fetal testis. PMID: 23303681
    10. A novel reciprocal loop between miR-21 and TGFbetaRIII in cardiac fibrosis caused by myocardial infarction in mice. PMID: 22960625
    11. These data suggest that Inhibins and TbetaRIII may function as a molecular pair regulating T cell development. PMID: 22952931
    12. the relative roles of TGFbetaR3-dependent and -independent signaling in the actions of BMP2 on epicardial cell behavior and demonstrate the critical role of TGFbetaR3 in mediating BMP2-stimulated invasion. PMID: 22237159
    13. used intact embryos and epicardial cells from E11.5 mouse embryos to reveal the mechanisms by which TGFbetaR3 signals and regulates epicardial cell behavior PMID: 21871877
    14. TGFBR3 can prevent hypoxia-induced injury in neonatal mice cardiac fibroblasts by negative regulation of TGF-beta signaling. PMID: 21792916
    15. Data present the 2.0-A resolution crystal structure of the betaglycan ZP-C region in combination with a downstream region known as the external hydrophobic patch. PMID: 21402931
    16. Tgfbr3 is associated with acute lung injury PMID: 21297076
    17. TbetaRIII enhanced both ALK3 & ALK6 signaling. TbetaRIII mediates differential ALK3 and ALK6 subcellular trafficking resulting in distinct signaling downstream of ALK3 and ALK6. PMID: 19726563
    18. required for normal seminiferous cord formation, normal fetal Leydig cell development, and the establishment of fetal testis endocrine function PMID: 19696014
    19. These results indicate that betaglycan expression is up-regulated during myogenesis and that MyoD and RA modulate its expression by a mechanism that is independent of myogenin. PMID: 12399463
    20. TbetaRIII is an important modulator of TGFbeta2 function in embryonic fibroblasts and reduced sensitivity to TGFbeta2 may underlie aspects of the TbetaRIII mutant phenotype PMID: 12773577
    21. TbetaRIII is not required for TGF-beta2 to signal when sufficient TGF-beta2, TbetaRI, and TbetaRII or TbetaRII-B are present PMID: 14996829
    22. TbetaRIII appeared to inhibit mammary tumor invasion by undergoing ectodomain shedding and producing soluble TbetaRIII. PMID: 17160136
    23. Tgfbr3 is required for coronary vessel development and embryonic viability. PMID: 17704211
    24. These data indicate that TbetaRIII acts as a tumor suppressor in nontumorigenic mammary epithelial cells at least in part by inhibiting NFkappaB-mediated repression of E-cadherin. PMID: 17823118
    25. Pronounced changes in the expression and localization of the TGF-beta receptors Tgfbr3 were noted as mouse lungs progressed through the canalicular, saccular, and alveolar stages of development. PMID: 18095342
    26. expressed at higher levels in the developing testis compared to ovary PMID: 18236212
    27. These results demonstrated that endocrine effects of inhibin as a negative feedback controller of follicle stimulating hormone production in gonadotropes are dependent on betaglycan expression. PMID: 19524135

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Secreted. Secreted, extracellular space, extracellular matrix.
  • 數(shù)據(jù)庫(kù)鏈接：