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  4. Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit

Mouse Tumor necrosis factor receptor superfamily member 17(TNFRSF17) ELISA kit

  • 中文名稱：
    小鼠腫瘤壞死因子配體超家族成員17(TNFSF17)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL023974MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠腫瘤壞死因子配體超家族成員17(TNFSF17)酶聯(lián)免疫試劑盒（CSB-EL023974MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TNFRSF17含量。TNFRSF17 是一個重要靶點。它屬腫瘤壞死因子受體超家族成員，在B淋巴細胞發(fā)育與功能維持中起關(guān)鍵作用。研究聚焦其信號傳導機制，探索與免疫疾病、血液系統(tǒng)腫瘤關(guān)聯(lián)，有望為相關(guān)疾病診斷和治療提供新思路。試劑盒檢測范圍為0.39 ng/ml- 25 ng/ml.，支持科研人員高效開展小鼠模型中的免疫調(diào)節(jié)研究、腫瘤微環(huán)境分析或炎癥性疾病機制探索，尤其適用于評估實驗動物體內(nèi)TNFSF17表達水平變化與特定病理狀態(tài)的相關(guān)性，為免疫學、分子生物學及藥理學研究提供可靠的數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Tnfrsf17; Bcm; Bcma; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD antigen CD269
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.39 ng/ml - 25 ng/ml.
  • 靈敏度：
    0.1 ng/ml.
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse TNFRSF17 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    99

    Range %

    90-104

    1:2

    Average %

    100

    Range %

    90-105

    1:4

    Average %

    96

    Range %

    89-100

    1:8

    Average %

    93

    Range %

    89-97

  • 回收率：

    The recovery of mouse TNFRSF17 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    93

    88-97

    EDTA plasma (n=4)

    102

    95-107

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    25

    2.606

    2.567

    2.587

    2.410

    12.5

    1.832

    1.795

    1.814

    1.637

    6.25

    1.229

    1.200

    1.215

    1.038

    3.125

    0.708

    0.688

    0.698

    0.521

    1.56

    0.425

    0.416

    0.421

    0.244

    0.78

    0.303

    0.289

    0.296

    0.119

    0.39

    0.229

    0.232

    0.231

    0.054

    0

    0.179

    0.175

    0.177

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
  • 基因功能參考文獻：
    1. high affinity antibody blocks the binding of the native ligands APRIL and BAFF to BCMA. This finding is rationalized by the high resolution crystal structure of the Fab fragment in complex with the extracellular domain of BCMA PMID: 25953704
    2. Elimination of B lymphocyte stimulator receptor 3 (BR-3) and BCMA inhibits the development of SLE in NZM mice. PMID: 25989238
    3. we have identified a novel role for BCMA to control excess BAFF production in murine lupus through restraining the accumulation of BAFF-producing neutrophils. PMID: 25010693
    4. Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR. PMID: 25953898
    5. BCMA is dispensable for the development of SLE in NZM mice. BAFF-BCMA interactions contribute to SLE. PMID: 23334904
    6. Study reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity. PMID: 21536804
    7. Blimp-1 is a positive regulator of the expression of BCMA gene in mouse plasma cells. PMID: 20339926
    8. The 5'-flanking sequence from -820 to +145 bp of BCMA is of promoter activity. PMID: 18687216
    9. A vital role of BCMA in bone marrow plasma cell survival. PMID: 14707116
    10. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. PMID: 16116167
    11. Review. APRIL interactions with BCMA likely govern memory B cell populations. PMID: 16919470
    12. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID: 16931039

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  • 亞細胞定位：
    Membrane; Single-pass type III membrane protein.
  • 組織特異性：
    Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.
  • 數(shù)據(jù)庫鏈接：