Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit
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中文名稱:小鼠腫瘤壞死因子受體超家族成員5(CD40)酶聯(lián)免疫試劑盒
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貨號:CSB-EL004936MO
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規(guī)格:96T/48T
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價格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:小鼠腫瘤壞死因子受體超家族成員5(CD40)酶聯(lián)免疫試劑盒(CSB-EL004936MO)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的CD40含量。CD40是一種腫瘤壞死因子受體超家族成員,主要表達在抗原遞呈細胞上,如樹突狀細胞、B細胞等。研究機制顯示,CD40激動劑能通過上調(diào)MHC分子、共刺激分子和TNF超家族配體,促進DCs成熟和抗原呈遞,激活T細胞,從而增強抗腫瘤免疫。試劑盒檢測范圍為31.2 pg/ml- 2000 pg/ml,靈敏度為7.8 pg/ml??蒲腥藛T可將其應用于免疫學機制研究、疾病動物模型評估(如系統(tǒng)性紅斑狼瘡、淋巴瘤等)或藥物干預實驗中的生物標志物檢測,特別適合需要多類型樣本兼容(包括血清、血漿及組織勻漿)的體外實驗場景。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名:Cd40; Tnfrsf5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CD antigen CD40
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縮寫:
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:31.2 pg/ml - 2000 pg/ml
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靈敏度:7.8 pg/ml
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Immunology
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貨期:3-5 working days
引用文獻
- Increased expression of CD40/TRAF1 and activation of nuclear factor-κκB-dependent proinflammatory gene expression in collagen-induced arthritis T Cheng, et al,Scandinavian Journal of Rheumatology,2018
相關(guān)產(chǎn)品
靶點詳情
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功能:Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
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基因功能參考文獻:
- these studies identify a PPARgamma-dependent miR-424/503-CD40 signaling axis that is critical for regulation of inflammation mediated angiogenesis PMID: 28566713
- Data indicate a CD40-dependent mechanism capable of abrogating receptor-related orphan gammat(+) (RORgammat(+)) Helios(-)-induced Treg (iTreg) cells induction by CD103(+) dendritic cells (DCs). PMID: 28276457
- Although either BCR or CD40 ligation induced c-Myc in naive B cells, both signals were required to highly induce c-Myc, a critical mediator of GC B cell survival and cell cycle reentry. PMID: 29396161
- These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms. PMID: 29111976
- Results suggest that platelet CD40 plays a pivotal role in neointima formation after arterial injury PMID: 29037856
- CD73 expression identifies a subset of IgM(+) antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent PMID: 28746783
- CD40 silencing with a specific siRNA ameliorates progression of experimental atherosclerosis in ApoE(-/-) mice via NF-kappaB/miR-125b signaling axis. PMID: 27835742
- CD40 functions as a non-redundant mechanism to convert the tumor microenvironment immunologically. PMID: 27292635
- CD40 plays a critical role in the pathogenesis of type 1 diabetes, influencing lymphocyte trafficking, T-cell receptor expression, and T-cell pathogenesis. PMID: 28542921
- role with b7 in primary germinal center generation of distinct antigen-presenting cells PMID: 28768709
- CD40 signaling in adipose tissue macrophages regulates major histocompatibility complex class II and CD86 expression to control the expansion of CD4(+) T cells. PMID: 26658005
- Adoptively transferred Th40 cells (CD4+CD40+ Tcells) are present in lesions in the CNS and are associated with wide spread demyelination. PMID: 28192476
- this study reports that anti-CD40 mAb administration <3 d in advance of chemotherapy is lethal in more than half of treated C57BL/6 mice in pancreatic cancer model PMID: 27217585
- The data show that CD40-mediated inhibition of PC generation is via engagement of multiple pathway and constitutive CD40 signaling in vivo involving bystander T-B interactions can calibrate B cell differentiation outcomes PMID: 27342845
- BAFF upregulates CD28/B7 and CD40/CD154 expression, and promotes the interactions between T and B cells in a BAFF-R-dependent manner PMID: 27180986
- CD40 in Muller cells is sufficient to upregulate retinal inflammatory markers and appears to promote experimental diabetic retinopathy and that Muller cells orchestrate inflammatory responses in myeloid cells through a CD40-ATP-P2X7 pathway. PMID: 27474370
- Taken together, our data demonstrate the importance of CD40 signaling in the conversion of CTL exhaustion and its ability to enhance PD-1 antagonist action in rescuing exhausted CTLs in chronic infection. PMID: 28153727
- Upon miR-155 overexpression, Cd40 expression was significantly upregulated with a negative correlation to the miR-155 primary target Ship1 expression in mice. PMID: 27509492
- These results suggest that Il23a expression in DCs is synergistically triggered by the PG E2-EP4-cAMP-PKA pathway and canonical/non-canonical NF-kappaB pathways and CREB activated by CD40 stimulation. PMID: 26189370
- Results suggest that altered CD40 signaling and granulocyte recruitment in response to infection are responsible for the Ity5-associated Salmonella susceptibility of A/J mice. PMID: 26562079
- our results highlight new roles for CD40 and cysteine-238-mediated CD40 homodimers in cell biology and identify a potential new target for therapeutic strategies against CD40-associated chronic inflammatory diseases. PMID: 25977307
- Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis PMID: 26356194
- Platelet CD40 plays a crucial role in inflammation by stimulating leukocyte activation and recruitment and activation of endothelial cells, thereby promoting atherosclerosis. PMID: 26821950
- there is a major involvement of the CD40-CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis. PMID: 25822797
- NIK, and thus probably the noncanonical NF-kappaB pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 T cells after exposure to licensing stimuli. PMID: 26561586
- C57-CD40L(-/-) mouse is a useful surrogate model of X-HIGM syndrome for studying immune responses elicited against pathogens PMID: 26064940
- although treated CD40 knockout mice remained healed, developed long-term immunity, and were resistant to secondary Leishmania major challenge, treated CD40L knockout reactivated their lesion after cessation of rIL-12 treatment. PMID: 26304989
- Anti-OX40L mAb could prolong secondary heart allograft survival based on CD40/CD40L and LFA-1/ICAM-1 blockade. PMID: 25613092
- CD40 on lymph node fibroblasts facilitated bidirectional communication with CD4(+) T cells via CD40-CD40L, thereby altering fibroblast gene expression of immune regulatory molecules. PMID: 25856408
- CD40L mediates neointima formation via its classic receptor CD40 rather than via its recently described novel interaction with Mac-1. PMID: 24652469
- p62 regulates CD40-mediated NF-kappaB activation in macrophages through interaction with TRAF6. PMID: 26133577
- Although LIGHT is critical for maintenance of primary Th1 response, it is dispensable during secondary anti-Leishmania immunity in the presence of functional CD40 signaling. PMID: 26026056
- Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein alpha (SIRPalpha) antagonists that enhance antibody-dependent cellular phagocytosis PMID: 25837251
- findings indicate that in a setting of acute hepatitis, tumor-induced hepatic myeloid-derived suppressor cel act as proinflammatory immune effector cells capable of killing hepatocytes in a CD40-dependent manner. PMID: 25616156
- These data reveal the L. major-enhanced CD40-induced N-Ras activation as a novel immune evasion strategy and the potential for Ras isoform-targeted antileishmanial immunotherapy and immunoprophylaxis. PMID: 25786685
- Data indicate a role of scaffold protein JLP in the bridging of CD40 antigen internalization and CD40-dependent signaling in B lymphocytes. PMID: 25586186
- CD40 is required for protective immunity against liver stage Plasmodium infection. PMID: 25646303
- demonstrates that the simultaneous silencing of CD40 and CD80 genes has synergistic effects in preventing allograft rejection, and may therefore have therapeutic potential in clinical transplantation PMID: 24886282
- an SHP-1-centered feedback system wherein SHP-1 modulates CD40-induced p38MAPK activation threshold and reciprocal ERK-1/2 activation, establishing itself as a critical regulator of CD40 signaling reciprocity PMID: 25187664
- results imply that any setting of T cell lymphopenia or reduced CD40 function, including B cell recovery following transplantation, will impact the naive B cell repertoire PMID: 25172502
- These results indicate that CD40 plays distinct roles in different tissues and, unexpectedly, plays an important role in maintaining immune homeostasis in epididymal adipose tissue. PMID: 24647739
- CD40 signaling activates naive B cells to a phenotype that is intermediate between the naive and plasma cell stages of the B cell differentiation. PMID: 24482285
- gammadelta T cells might activate dendritic cells via CD40 signalling during infection. Dendritic cell activation via gammadelta T cells expressing CD40 ligand is critical during the early phase of infection with Plasmodium berghei XAT. PMID: 24815981
- We present the surprising finding that CD40 deficiency on T cells aggravates whereas activation of CD40 signaling improves adipose tissue inflammation and its metabolic complications. PMID: 24664276
- Fas signals act as a silencing mechanism for CD40-induced RAGs and prevent CD40 translocation to the nucleus. PMID: 24037181
- Data indicate that CD40-CD154 interactions drive the functional activation of steady-state dendritic cells. PMID: 24420080
- Data indicate that CD40 stimulation enhanced only TLR-9 expression. PMID: 24387292
- Data suggest that simultaneous knock-down of CD40 and IL-23p19 production by bone marrow-derived DCs (BMDCs) may represent a therapeutic tool for the treatment of IL-17-dependent autoimmune diseases, including multiple sclerosis. PMID: 24387596
- CD40 plays a crucial role as an important costimulatory molecule in experimental autoimmune neuritis. PMID: 24709684
- The CD40/CD40L-assisted crosstalk between mesenchymal stromal cells and mast cells in the splenic marginal zone lymphoma (SMZL) microenvironment finds correlation in p53(-/-) mice developing SMZL. PMID: 24452203
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亞細胞定位:[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform III]: Cell membrane; Single-pass type I membrane protein.; [Isoform IV]: Cell membrane; Single-pass type I membrane protein.; [Isoform V]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
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