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Mouse Uromodulin(UMOD) ELISA kit

  • 中文名稱:
    小鼠尿調(diào)節(jié)蛋白(UMOD)酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-EL025616MO
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠尿調(diào)節(jié)蛋白(UMOD)酶聯(lián)免疫試劑盒(CSB-EL025616MO)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿樣本中的UMOD含量。UMOD即尿酸調(diào)節(jié)蛋白,它在腎臟生理中發(fā)揮重要作用。研究發(fā)現(xiàn),UMOD基因變異與一些腎臟疾病如多囊腎病、高血壓等相關(guān)。其作用機(jī)制可能涉及調(diào)節(jié)腎小管對(duì)電解質(zhì)的重吸收、影響腎臟局部血流動(dòng)力學(xué)等,深入研究UMOD有助于揭示腎臟疾病發(fā)病機(jī)制。試劑盒檢測(cè)范圍為6.25 ng/mL-400 ng/mL,該產(chǎn)品廣泛用于小鼠腎臟功能研究、泌尿系統(tǒng)疾病模型建立(如慢性腎病、高血壓模型)及藥物干預(yù)實(shí)驗(yàn)中UMOD動(dòng)態(tài)變化的監(jiān)測(cè),可為腎臟生理機(jī)制探索、病理模型驗(yàn)證及治療策略開發(fā)提供可靠數(shù)據(jù)支持本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說(shuō)明書。
  • 別名:
    Umod ELISA Kit; Uromodulin ELISA Kit; Tamm-Horsfall urinary glycoprotein ELISA Kit; THP) [Cleaved into: Uromodulin ELISA Kit; secreted form] ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍:
    6.25 ng/mL-400 ng/mL
  • 靈敏度:
    1.56 ng/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Others
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.; In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.
  • 基因功能參考文獻(xiàn):
    1. these data support THP as an important negative regulator of neutrophil activation in the urinary tract, with dual functions to counteract bacterial colonization and suppress excessive inflammation within the urinary tract PMID: 28829050
    2. this study shows that uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells PMID: 28992252
    3. results strongly suggest that the progressive worsening of kidney functions reflects the accumulation of the deleterious effects of the misfolded mutant THP and the compensatory responses PMID: 29145399
    4. Endoplasmic reticulum stress and apoptosis are key features in a mouse model of kidney disease driven by the uromodulin p.Cys147Trp mutation. PMID: 28990932
    5. Consistently, pathway enrichment analysis indicates that mutant uromodulin expression affects ER function and protein homeostasis. PMID: 28437467
    6. we show that Tamm-Horsfall protein deficiency stimulates proximal epithelial activation of the Interleukin-23/Interleukin-17 axis and systemic neutrophilia. PMID: 25556169
    7. AGP was more effective in limiting hepatic inflammation and maintaining perfusion than saline or HAS, in both endotoxemic and septic mice. AGP sequestration of LPS may contribute to its anti-inflammatory effects. PMID: 23941548
    8. UMOD upregulates TRPV5 by decreasing caveolin-1 dependent endocytosis of TRPV5. PMID: 23466996
    9. UMOD regulates sodium uptake in the thick ascending limb of the loop of Henle by modulating the effect of tumor necrosis factor-alpha on NKCC2A expression, making UMOD an important determinant of blood pressure control. PMID: 24324041
    10. Genetic susceptibility link to hypertension and chronic kidney disease to uromodulin expression and uromodulin's effect on salt reabsorption in the kidney. PMID: 24185693
    11. Using an ischemia-reperfusion model of murine acute kidney injury, we show that, while THP expression in thick ascending loop is downregulated at the peak of injury, it is significantly upregulated 48 h after. PMID: 23389456
    12. Quercetin has the uricosuric and nephroprotective actions mediated by regulating the expression levels of renal organic ion transporters and UMOD. PMID: 21909718
    13. a unifying model that underscores the role of THP as a major regulator of renal and systemic immunity. PMID: 22451664
    14. Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones. PMID: 22117067
    15. Deletion of the von Hippel-Lindau protein (Vhl), which mediates HIF degradation under normoxia, using Tamm-Horsfall protein (Thp)-driven Cre expression showed strong expression of HIF-1alpha in thick ascending limb. PMID: 21921145
    16. THP-null mouse may have a distal tubular defect and thus mimics ileostomy patients with low urine volumes and acidic urine. PMID: 21063698
    17. THGP modulation of ROMK function confers a new role of THGP on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2/GCKD patients. PMID: 21081491
    18. These data clearly demonstrate a gain-of-toxic function of uromodulin mutations providing insights into the pathogenetic mechanism of the disease. PMID: 20472742
    19. Normal Tamm-Horsfall protein (THP) plays an important role in defending the urinary system against calcification. Reduced expression and/or decreased function of THP could contribute to nephrolithiasis. PMID: 20591941
    20. proximal 5'-flanking sequence is sufficient to drive the kidney-specific expression of a heterologous reporter gene PMID: 11880321
    21. potential THP defects, either quantitative or qualitative, could predispose the urinary bladder to bacterial infections PMID: 14665435
    22. THP serves as a soluble receptor for type 1 fimbriated E. coli and helps eliminate bacteria from the urinary tract. PMID: 14871399
    23. THP is a critical urinary defense factor and its deficiency could be an important contributing factor in nephrolithiasis PMID: 15327412
    24. Tamm-Horsfall glycoprotein plays an important regulatory role in the kidney PMID: 15522986
    25. The genes encoding pre-pro-epidermal growth factor (pre-pro-EGF) and Tamm-Horsfall protein (THP)/uromodulin were aberrantly expressed in the kidneys of COX-2 -/- mice at all stages of their development. PMID: 15741608
    26. Whole urine from osteopontin, Tamm-Horsfall protein , or double-null mice all possessed a dramatically reduced ability to inhibit the adhesion of calcium oxalate monohydrate crystals to renal epithelial cells PMID: 17898038
    27. Urinary uromodulin is generated by a conserved C-terminal proteolytic cleavage and retains its entire ZP domain. PMID: 18375198
    28. The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens. PMID: 18830570
    29. Letter: Tamm-Horsfall protein knockout mice have increased stress induced micturition. PMID: 19214995
    30. Umod might act as a gain-of-toxic-function mutation PMID: 19692485

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  • 亞細(xì)胞定位:
    [Uromodulin, secreted form]: Secreted.; Apical cell membrane; Lipid-anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI-anchor. Cell projection, cilium membrane.
  • 組織特異性:
    Detected in urine (secreted form). Detected in kidney thick ascending limb epithelial cells (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接: