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Mouse Vascular cell adhesion molecule 1,VCAM-1 ELISA kit

  • 中文名稱:
    小鼠血管內(nèi)皮細(xì)胞粘附分子1(VCAM-1/CD106)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-E04754m
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3800/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠血管內(nèi)皮細(xì)胞粘附分子1(VCAM-1/CD106)酶聯(lián)免疫試劑盒(CSB-E04754m)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的VCAM1含量。VCAM1(血管細(xì)胞粘附分子1)是一種細(xì)胞表面糖蛋白,屬于免疫球蛋白超家族。它主要在活化的內(nèi)皮細(xì)胞表面表達(dá),通過與白細(xì)胞表面的特定分子結(jié)合,調(diào)節(jié)炎癥反應(yīng)和白細(xì)胞遷移。VCAM1在免疫反應(yīng)和炎癥過程中發(fā)揮重要作用,其表達(dá)增加與多種免疫性疾病和癌癥的進(jìn)展密切相關(guān)。研究顯示,VCAM1通過調(diào)節(jié)小膠質(zhì)細(xì)胞的功能和Aβ的清除,在阿爾茨海默病的發(fā)生發(fā)展中扮演關(guān)鍵角色。試劑盒檢測范圍為39.062 pg/mL-2500 pg/mL,靈敏度為29.649 pg/mL。適用于體外研究血管內(nèi)皮細(xì)胞活化狀態(tài)、炎癥反應(yīng)機(jī)制、藥物干預(yù)效果評估等科研領(lǐng)域,為心血管疾病、免疫調(diào)控及腫瘤微環(huán)境等領(lǐng)域的機(jī)制研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Vcam1; Vcam-1; Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; CD antigen CD106
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍:
    39.062 pg/mL-2500 pg/mL
  • 靈敏度:
    29.649 pg/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Cardiovascular
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

     

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

     

  • 線性度:

     

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse VCAM-1/CD106 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

     

  • 標(biāo)準(zhǔn)曲線:

     

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

     

  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展:
    VCAM1是一種黏附分子,參與細(xì)胞黏附和遷移過程,已被證實(shí)與許多疾病的發(fā)生和發(fā)展有關(guān),如動脈粥樣硬化和腫瘤的形成。最新的研究表明,VCAM1可能參與心血管疾病的發(fā)生和發(fā)展,并被認(rèn)為是一種治療心血管疾病的潛在靶點(diǎn)。此外,VCAM1的水平還可以作為某些疾病的診斷和預(yù)后標(biāo)志物。
  • 功能:
    Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
  • 亞細(xì)胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.
  • 組織特異性:
    Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
  • 數(shù)據(jù)庫鏈接: