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  4. Mouse chemokine (C-C motif) ligand 1 ELISA Kit

Mouse chemokine (C-C motif) ligand 1 ELISA Kit

  • 中文名稱：
    小鼠趨化因子配體1酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E14298m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠趨化因子配體1酶聯(lián)免疫試劑盒（CSB-E14298m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL1含量。CCL1，即趨化因子（C-C motif）配體1，是一種小糖蛋白，屬于CC趨化因子家族。CCL1由活化的單核細胞、巨噬細胞、T淋巴細胞和內(nèi)皮細胞分泌，對單核細胞具有趨化性。CCL1通過與其受體CCR8相互作用，調(diào)節(jié)組織穩(wěn)態(tài)，參與炎癥過程，并在血管生成和腫瘤發(fā)生中發(fā)揮關(guān)鍵作用。試劑盒檢測范圍為7.8 pg/ml-500 pg/ml，靈敏度為1.95 pg/ml。該產(chǎn)品可應用于基礎(chǔ)科研中評估炎癥模型小鼠的CXCL1動態(tài)表達、探索腫瘤微環(huán)境中趨化因子的調(diào)控機制，或用于藥物干預實驗中的生物標志物檢測，為炎癥性疾病和腫瘤免疫研究提供可靠的實驗工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ccl1 ELISA kit; Scya1 ELISA kit; Tca3C-C motif chemokine 1 ELISA kit; P500 ELISA kit; SIS-epsilon ELISA kit; Small-inducible cytokine A1 ELISA kit; T-cell activation protein 3 ELISA kit; TCA-3 ELISA kit; TCA3 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    7.8 pg/ml -500 pg/ml
  • 靈敏度：
    1.95 pg/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytokine that is chemotactic for neutrophils.
  • 基因功能參考文獻：
    1. Findings provide evidence that CCL1 possibly contributes to 5-fluorouracil/paclitaxel chemoresistance in CT26 colorectal cell line via TGF-beta and nuclear factor-kappa B signaling pathways. PMID: 28934847
    2. Sca-1(+) progenitor cells found to exhibit increased migration was associated with elevated levels of chemokines, CCL2 (chemokine (C-C motif) ligand 2) and CXCL1 (chemokine (C-X-C motif) ligand 1), and their corresponding receptors. PMID: 27300479
    3. Study reports showing that I. ricinus saliva can increase the production of three chemokines, CCL1, CCL2 and CXCL2. This upregulation reflects Th2 polarization of the host immunity due to the effect of tick saliva and in the case of CCL2 probably facilitates tick engorgement in the late, rapid feeding phase. PMID: 25545116
    4. Our data indicate that estradiol is important in regulating the effects of keratinocyte growth factor on mouse uterine epithelial cell secretion of CCL20 and CXCL1. PMID: 24807244
    5. CCL-1 is one of the key molecules in pathogenesis in neuropathic pain. PMID: 23788036
    6. These data identify a novel function for CCL1-CCR8 in metastasis and lymph node LECs as a critical checkpoint for the entry of metastases into the lymph nodes. PMID: 23878309
    7. Egr2-deficient mast cells were incapable of directing CD4(+) T cell migration via the CCL1-CCR8 axis. PMID: 23536637
    8. results indicate that CCL1 released from M2bM is essentially required for the maintenance of their properties PMID: 22730547
    9. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
    10. These findings reveal the importance of CXCL1 produced by hematopoietic and resident cells in regulating pulmonary host defense against a bacterial pathogen PMID: 20937845
    11. neutralization of CCL1 can be used as an adjuvant to antitumor immunotherapy, as a means of reversing the immunosuppressive function of Tregs without compromising T cell effector function. PMID: 20483762
    12. increased responsivenss of murine eosiophils to TCA-3 is mediated by CCR8 receptor in mice PMID: 12050188
    13. After stimulation via high-affinity FcepsilonRI, the transcriptional levels of I-309 (CCL1), MIP-1alpha (CCL3) and MIP-1beta (CCL4) were found among the 10 most increased human and mouse transcripts from approximately 12 000 genes PMID: 12393595
    14. CCL1 is involved in the recruitment of eosinophils in several models of allergic inflammation, but it is not important for the recruitment of Th2 cells to the lung. PMID: 12707363
    15. Benzo(a)pyrene and an aryl hydrocarbon receptor agonist enhance activitity of te Ccl1 promoter. PMID: 16679317
    16. These data demonstrate that the chemokine TCA3/CCL1 is important to the pathogenesis of ischemic injury of experimental partial liver grafts. PMID: 17164723
    17. Mast cell-derived CCL1- and CCR8-expressing CD4-positive effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses. PMID: 17641040
    18. CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation PMID: 17947648
    19. lovastatin-induced increase in regulatory T cells in inflamed skin was dependent on expression of CCL1, that is locally up-regulated by statin administration. PMID: 18714025
    20. In a novel mechanism, IL-12 augments naive CD8 T cell activation by facilitating CCL1 production by dendritic cells, thus promoting more stable cognate interactions during priming. PMID: 19050277

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  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:20290

    STRING: 10090.ENSMUSP00000103824

    UniGene: Mm.1283