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  4. Mouse chemokine (C-X-C motif) ligand 17 (CXCL17) ELISA kit

Mouse chemokine (C-X-C motif) ligand 17 (CXCL17) ELISA kit

  • 中文名稱：
    小鼠趨化因子配體17(CXCL17)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL006246MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠趨化因子配體17(CXCL17)酶聯(lián)免疫試劑盒（CSB-EL006246MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CXCL17含量。CXCL17 是一種趨化因子。目前對它的研究顯示，其在免疫調(diào)節(jié)等方面有潛在作用。研究機(jī)制上，它可吸引特定免疫細(xì)胞，參與炎癥反應(yīng)及腫瘤微環(huán)境調(diào)控等過程，不過對其具體作用路徑和分子機(jī)制還需進(jìn)一步深入探索。試劑盒檢測范圍為37.5 pg/mL-2400 pg/mL，科研人員可將其應(yīng)用于炎癥性疾病機(jī)制研究、免疫微環(huán)境分析或藥物干預(yù)模型中趨化因子動態(tài)變化的評估，為探索CXCL17在先天免疫調(diào)控、組織修復(fù)及病理狀態(tài)下的功能提供可靠工具。CXCL17作為新型趨化因子家族成員，在黏膜免疫調(diào)節(jié)及炎癥反應(yīng)中發(fā)揮重要作用，尤其在呼吸道和消化道相關(guān)疾病模型中具有研究價值。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cxcl17 ELISA kit; Vcc1C-X-C motif chemokine 17 ELISA kit; 6-Cys CXCL17 ELISA kit; 13.6 kDa protein ELISA kit; VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17] ELISA kit
  • 縮寫：
    CXCL17
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    37.5 pg/mL-2400 pg/mL
  • 靈敏度：
    9.375 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.
  • 基因功能參考文獻(xiàn)：
    1. CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin. PMID: 28389593
    2. CXCL17 is a novel macrophage chemoattractant that operates in mucosal tissues as a major regulator of inflammatory responses. PMID: 24973458
    3. These results suggest that aberrant expression of CXCL17 in tumor cells recruits immature myeloid-derived cells and promotes tumor progression through angiogenesis. PMID: 22952881
    4. VCC-1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types[VCC-1] PMID: 16989774
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 組織特異性：
    Detected in lung, trachea, lung, tongue thyroid, submaxillary gland, epididymis, and uterus tissues and at a lower level in ovary, prostate and in intestinal tissues.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:232983

    UniGene: Mm.10545