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  4. Mouse coagulation factor Ⅹ,FⅩ ELISA Kit

Mouse coagulation factor Ⅹ,FⅩ ELISA Kit

  • 中文名稱：
    小鼠凝血因子Ⅹ(FⅩ)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E08442m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠凝血因子Ⅹ(FⅩ)酶聯(lián)免疫試劑盒（CSB-E08442m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的F10含量。F10即凝血因子X，在凝血級聯(lián)反應(yīng)中起關(guān)鍵作用。作為血漿中一種重要凝血蛋白。研究機(jī)制方面，主要是被激活后參與凝血酶原向凝血酶轉(zhuǎn)化過程，促進(jìn)纖維蛋白形成，實(shí)現(xiàn)凝血。對F10研究有助于研發(fā)抗凝藥物。試劑盒檢測范圍為0.312 μg/mL-20 μg/mL，廣泛應(yīng)用于小鼠模型中凝血功能異常研究、抗凝藥物作用機(jī)制探索、遺傳性出血性疾病模型評估等科研領(lǐng)域，為心血管疾病、血栓形成機(jī)制及凝血相關(guān)通路的基礎(chǔ)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    F10Coagulation factor X ELISA Kit; EC 3.4.21.6 ELISA Kit; Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain] ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    0.312 μg/mL-20 μg/mL
  • 靈敏度：
    0.078 μg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Blood Coagulation
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
  • 基因功能參考文獻(xiàn)：
    1. PTX2 was identified PTX2 as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages. PMID: 28213380
    2. Enhanced FXa and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy. PMID: 27283743
    3. Macrophages regulate FX plasma levels in an SR-AI-dependent manner. PMID: 26608330
    4. Factor Xa has a role in inhibiting HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice PMID: 25007770
    5. Selective inhibition of FXa improves the left ventricular function during CVB3-induced myocarditis and seems to be associated with an improved myocardial remodeling. PMID: 24533719
    6. Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells. PMID: 23872307
    7. Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate. PMID: 21596747
    8. There was no detectable increase in plasma levels of mouse FX after active-site inhibited human APC administration to mice overexpressing human EPCR. FX does not effectively interact with EPCR in vivo, at least in regards to the mouse system. PMID: 21885613
    9. investigation of role of F10a in progression of diabetic nephropathy: data from studies using inhibitor of F10a suggest that F10a does play a role in development of proteinemia, glomerular hypertrophy, and protein deposition in kidney of db/db mice PMID: 21628879
    10. Data suggest that tissue factor and factor V induction by LPS may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms. PMID: 19546589
    11. Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development PMID: 11841337
    12. Factor Xa functions in airway remodeling in asthma by stimulating mucin production, through regulation of amphiregulin expression and collagen deposition. PMID: 17082493
    13. Complete absence of FX is incompatible with murine survival. Minimal FX activity as low as 1-3% is sufficient to rescue the lethal phenotype. PMID: 18036190
    14. Results show that although factor Xa induces p42/44 MAP Kinase phosphorylation in endothelial cells, it has no direct effect on endothelial cell proliferation, protein synthesis and tube formation. PMID: 19339215
    15. expression of coagulation factor X (FX) is locally increased in fibrotic lung tissue, with marked immunostaining associated with bronchial and alveolar epithelia PMID: 19652365

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 組織特異性：
    Plasma; synthesized in the liver.
  • 數(shù)據(jù)庫鏈接：