Mouse ghrelin (GHRL) ELISA Kit
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中文名稱(chēng):小鼠饑餓激素(GHRL)酶聯(lián)免疫試劑盒
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貨號(hào):CSB-E09817m
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規(guī)格:96T/48T
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價(jià)格:¥3800/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:小鼠饑餓激素(GHRL)酶聯(lián)免疫試劑盒(CSB-E09817m)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿樣本中的GHRL含量。GHRL即胃饑餓素。它由胃分泌,是一種具有多種生理功能的內(nèi)源性肽。在研究機(jī)制上,它能作用于下丘腦等部位調(diào)節(jié)食欲和能量平衡,還參與調(diào)節(jié)胃腸道功能、糖脂代謝等,目前圍繞它在肥胖、糖尿病等疾病治療方面的研究較多。試劑盒檢測(cè)范圍為1.37 pg/ml- 1000 pg/ml,靈敏度為1.37 pg/ml。適用于科研領(lǐng)域中對(duì)能量代謝調(diào)控機(jī)制、進(jìn)食行為相關(guān)神經(jīng)通路以及藥物干預(yù)效果的評(píng)價(jià)。其兼容多種生物樣本的特性,可滿(mǎn)足動(dòng)物模型血清/血漿中循環(huán)GHRL水平檢測(cè),或特定組織(如胃、下丘腦)中局部表達(dá)量的分析需求,為代謝研究、生理病理機(jī)制探索及營(yíng)養(yǎng)學(xué)實(shí)驗(yàn)提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名:Ghrl ELISA Kit; MtlrpAppetite-regulating hormone ELISA Kit; Growth hormone secretagogue ELISA Kit; Growth hormone-releasing peptide ELISA Kit; Motilin-related peptide ELISA Kit; Protein M46) [Cleaved into: Ghrelin; Obestatin] ELISA Kit
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縮寫(xiě):
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Uniprot No.:
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種屬:Mus musculus (Mouse)
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樣本類(lèi)型:serum, plasma, tissue homogenates
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檢測(cè)范圍:1.37 pg/ml - 1000 pg/ml
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靈敏度:1.37 pg/ml
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測(cè)波長(zhǎng):450 nm
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研究領(lǐng)域:Cardiovascular
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測(cè)定原理:quantitative
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測(cè)定方法:Sandwich
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精密度:
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線(xiàn)性度:
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回收率:
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標(biāo)準(zhǔn)曲線(xiàn):
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- Central and cardiac stress resiliences consistently linked to integrated immuno‐neuroendocrine responses across stress models in male mice TJ Helman,European journal of neuroscience,2023
- TM4SF5-mediated abnormal food-intake behavior and apelin expression facilitate non-alcoholic fatty liver disease features YD Pinanga,iScience,2023
- “Behavior” of the Hormonal Ensemble through the Prism of Cluster Analysis VV Tolchennikova,Bulletin of Experimental Biology and Medicine,2020
- Chronic type 2 but not type 1 diabetes impairs myocardial ischaemic tolerance and preconditioning in C57Bl/6 mice Russell J S, et al,Experimental Physiology,2019
- Ghrelin improves muscle function in dystrophin-deficient mdx mice by inhibiting NLRP3 inflammasome activation Leilei Chang, et al,Life Sciences,2019
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靶點(diǎn)詳情
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最新研究進(jìn)展:GHRL,全稱(chēng)為生長(zhǎng)激素釋放激素受體(growth hormone-releasing hormone receptor)激動(dòng)劑,是一種神經(jīng)肽激素,可以通過(guò)激活GHRL受體來(lái)促進(jìn)生長(zhǎng)激素的釋放。最近的研究表明,GHRL可能在疾病的發(fā)生和發(fā)展中發(fā)揮了一定的作用。例如,GHRL與代謝疾病,如肥胖癥和糖尿病,以及消化系統(tǒng)疾病,如胃炎和胃潰瘍,都有關(guān)聯(lián)。此外,GHRL還被認(rèn)為可能具有抗炎和抗腫瘤的作用。這些研究表明,GHRL可能是一種重要的潛在治療靶點(diǎn)。
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功能:Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.; Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
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基因功能參考文獻(xiàn):
- Thus, the adipogenic action of exogenous unacylated ghrelin in tibial marrow is dependent upon acylation by GOAT and activation of GHS-R1a. PMID: 28361877
- suppression of the Akt signaling pathway and activation of NF-kappaB signaling in chondrocytes during Osteoarthritis (OA) development was antagonized by ghrelin administration. This supports the assessment of ghrelin as a potential therapeutic approach to treat degenerative cartilage diseases, including OA PMID: 29070587
- the effect of GOAT on gastric acid secretion and expression of ghrelin in vitro, were investigated. PMID: 29966658
- Results suggest that hypothalamic peroxisome proliferator-activated receptor-gamma plays a vital role in ghrelin production and food intake in mice. PMID: 29655655
- The aim of the present study was to determine whether arcuate nucleus (ARC) lesions affect the ghrelin level in the plasma and the stomach in monosodium glutamate (MSG)treated mice. PMID: 29328403
- this study shows that nanogel-based nasal ghrelin vaccine prevents obesity PMID: 28120848
- Upregulation of unacylated ghrelin levels in mdx mice reduces muscle degeneration, improves muscle function, and increases dystrophin-null satellite cells (SC) self-renewal, maintaining the SC pool. PMID: 28436144
- These findings suggest that phasic activation of the SNc-ghrelin system could improve the dysregulation of nigrostriatal DA transmission related to the initial stage of PD, but not the motor deficits under the depletion of nigrostriatal DA. Although GHSRs are found in non-DA cells of the SNr, GHSRs on DA neurons in the SNc may play a crucial role in motor function. PMID: 29378186
- it showed that the antinociception of ghrelin was correlated with the GHS-R1alpha and d-opioid receptors. Finally, the antinociception induced by deltorphin II wasn't blocked by the co-injection (i.c.v.) of [D-Lys(3)]-GHRP-6, indicating that the GHS-R1a isn't on the backward position of delta opioid receptor. PMID: 27474249
- Deletion of ghrelin prevents aging-associated obesity and muscle dysfunction without affecting longevity. PMID: 28585250
- ghrelin binds to serum albumin and that this interaction impacts on the biological activity of the hormone. PMID: 27431015
- ghrelin has a critical role in preventing hypoglycemia and promoting survival during severe caloric restriction, a process that requires cell-expressed beta1AR PMID: 27548523
- findings show that the capacity of circulating ghrelin to acutely induce gastric emptying in mice requires the integrity of the area postrema, which contains a population of GABA neurons that are a target of plasma ghrelin PMID: 28204197
- Des-acylated ghrelin reduced blood-brain barrier disruption in vivo and attenuated the hyper-permeability of mouse cerebral microvascular endothelial cells after oxygen glucose deprivation. PMID: 27303049
- des-acyl ghrelin produces an anxiogenic effect under nonstressed conditions, but this switches to an anxiolytic effect under stress PMID: 27490185
- data support the notion that ghrelin activates ParaVentricular Nucleus CRF neurons via inhibition of local GABAergic tone, in an Arcuate nucleus-independent manner. PMID: 26874559
- ghrelin may mediate part of its metabolic actions through modulation of hypothalamic astrocytes and that this effect could involve astrocyte mediated changes in local glucose and glutamate metabolism that alter the signals/nutrients reaching neighboring neurons. PMID: 27026049
- These studies reemphasize the beneficial effects imparted by co-administration of obestatin and CCK8 and their potential use towards countering obesity. PMID: 27032885
- Stress in a postpartum mother has persistent effects on the body weight of their offspring. Increased ghrelin and decreased leptin expression in the stomach may play a role in these effects. PMID: 26884874
- Data (including data from studies in cell line from knockout mice) suggest high incorporation of long-chain fatty acids, partly mediated by Acsl1, plays role in supply of octanoic acid for ghrelin acylation/lipoylation in ghrelin-producing cells. PMID: 26991015
- Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp) and neuropeptide Y (Npy) gene expression similarly in Ghrelin+/+, Ghrelin-/-, ghrelin receptor Ghsr+/+, and Ghsr-/- mice. PMID: 26812158
- The expression of ghrelin and GH secretagogue receptor 1a [GHSR1a] in cerebral arteries and the effects of ghrelin analogs on cerebrovascular function are reproted.[GHSR1a] PMID: 25322462
- Pax6 inactivation in the adult pancreas reveals ghrelin as endocrine cell maturation marker. PMID: 26658466
- Thus, GHSR1a differentially inhibits CaV2 channels by Gi/o or Gq protein pathways depending on its mode of activation. PMID: 26283199
- results demonstrate that ghrelin, which signals acute hunger, renders the olfactory system more responsive to odors PMID: 26071307
- investigated whether ghrelin may cause alteration in neurite outgrowth and electrophysiological properties of tyrosine hydroxylase neurons from the ventrolateral arcuate nucleus PMID: 26385180
- Ghrelin is an inducer of myoprotective autophagy in myocardial and skeletal muscle ischemia. PMID: 26066847
- The expressions of both ghrelin and its receptor were observed in NPCs using RT-PCR, Interestingly, the exposure of fetal NPCs to ghrelin suppressed their proliferation, and caused them to differentiate into neurons PMID: 25828736
- Co-localization of TRPA1 and ghrelin in enteroendocrine cells of the duodenum is observed both in vivo and in the MGN3-1 cell line, a ghrelin secreting cell model, where incubation with CIN up-regulates expression of TRPA1 and Insulin receptor genes. PMID: 25605129
- Overproduction of ghrelin via an AAV viral delivery system in the hypothalamus leads to an increase in food intake associated with increases in body weight. This effect disappears after 3 weeks. PMID: 25801577
- Plasma acylated ghrelin levels decreased in stressed aged male mice. Suppressed feeding behavior in novelty stress-exposed aged male mice may be mediated by 5-HT(2C)R hypersensitivity, leading to hypoghrelinemia. PMID: 25732068
- dietary restriction increased survival of newborn cells in hippocampus of wild-type but not ghrelin knockout mice. PMID: 25735661
- Ghrelin induces intracellular store-mediated rises in calcium in laterodorsal tegmental neurons in mouse brain slices. PMID: 25645492
- Acylated ghrelin is not required for the surge in pituitary growth hormone observed in pregnant mice. PMID: 25645493
- There was increase in ghrelin gene transcripts and protein in HNF1a-null mice. Upregulation of ghrelin in the absence of Hnf1alpha impairs insulin secretion Inhibition of ghrelin/ghrelin receptor signaling led to a recovery of the diabetic symptoms. PMID: 25979074
- ghrelin and Bmal1 regulate the extent of body weight restoration during restricted feeding PMID: 25329803
- Ghrelin signaling is an important thermogenic regulator in aging. PMID: 25543537
- these data suggest that circulating ghrelin does not play a crucial role in feeding behavior, but rather is involved in maintaining body weight. PMID: 25029956
- peripherally administered ghrelin mainly accesses the Arcuate n. which is required for the orexigenic effects of the hormone. Centrally administered ghrelin accesses a variety of nuclei, which can mediate the orexigenic effects of the hormone. PMID: 24888783
- these data reveal that ghrelin plays an inhibitory role in the development of hypothalamic neural circuits and suggest that proper expression of ghrelin during neonatal life is pivotal for lifelong metabolic regulation. PMID: 25607843
- obestatin and Nt8U triggers lipid catabolism... The free fatty acids and lysophosphatidic acid thus produced in turn activates peroxisome proliferator-activated receptor gamma and the genes involved in peroxisome proliferator-activated receptor signaling PMID: 24937751
- Ghrl-/- mice had lower cortical bone mass, whereas Ghsr-/- mice had lower trabecular bone mass. This demonstrates bone compartment-specific effects of acetylated ghrelin and a role for Unacetylated ghrelin in bone metabolism. PMID: 25060361
- I cells in duodenum are enriched in expression of CCK and ghrelin. PMID: 25004095
- Ghrelin is a regulator of GH pulse amplitude in growing mice. PMID: 24949662
- Suggest a radioprotective role of ghrelin in differentiating spermatogonia exposed to ionizing radiation. PMID: 24853426
- Data suggest signal transduction via Ghrl/Crhr2 (corticotropin release factor type 2 receptor) plays role in regulation of muscle glucose metabolism; Ghsr1a (Ghrl receptor type 1A) was not detected in mouse myoblast cell line (C2C12) investigated. PMID: 23804489
- Findings support a role for ghrelin as an endogenous modulator of inflammatory responses and a central component of arousal and feeding circuits. PMID: 24309634
- The findings reveal a major, novel role for ghrelin in mediating ethanol behavior, and add to growing evidence that ghrelin is a key mediator of the effects of multiple abused drugs. PMID: 23428971
- RKT administration (500 mg/kg, per os) improved the decrease in 6 h cumulative food intake. In control mice, the plasma acylated ghrelin levels significantly increased by 24 h fasting. PMID: 24288687
- Ghrelin improves gastric growth and gastric acid secretion with decreased somatostatin mRNA in weaned mice. PMID: 23820307
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亞細(xì)胞定位:Secreted.
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蛋白家族:Motilin family
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組織特異性:Mainly expressed in the gastrointestinal tract with higher levels in the stomach, medium levels in the duodenum, jejunum, ileum and colon. Low expression in the testis and brain. Not detected in the salivary gland, pancreas, liver and lung.
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