-
中文名稱:小鼠顆粒酶A(Gzms-A)酶聯免疫試劑盒
-
貨號:CSB-E08717m
-
規(guī)格:96T/48T
-
價格:¥3800/¥2500
-
其他:
產品詳情
-
產品描述:小鼠顆粒酶A(Gzms-A)酶聯免疫試劑盒(CSB-E08717m)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿,組織勻漿樣本中的GZMA含量。GZMA是重要靶點。它在機體生理和病理過程中發(fā)揮關鍵作用。研究機制上,其可參與免疫調節(jié)、細胞殺傷等過程。對它的研究有助于深入理解相關疾病發(fā)病機制,為開發(fā)針對性的免疫治療藥物等提供理論依據,推動疾病治療的發(fā)展。試劑盒檢測范圍為6.25 pg/mL-400 pg/mL,為研究免疫細胞活性、感染性疾病機制、腫瘤免疫微環(huán)境或自身免疫性疾病模型提供可靠工具;尤其適合動態(tài)監(jiān)測實驗動物模型中顆粒酶 A 的分泌變化,例如評估免疫治療干預后的效應細胞功能或解析免疫相關信號通路的調控機制;是基礎免疫學研究和轉化醫(yī)學應用的優(yōu)選方案。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
-
別名:Gzma ELISA Kit; Ctla-3 ELISA Kit; Ctla3 ELISA Kit; Mtsp-1 ELISA Kit; Granzyme A ELISA Kit; EC 3.4.21.78 ELISA Kit; Autocrine thymic lymphoma granzyme-like serine protease ELISA Kit; CTLA-3 ELISA Kit; Fragmentin-1 ELISA Kit; T cell-specific serine protease 1 ELISA Kit; TSP-1 ELISA Kit
-
縮寫:GZMA
-
Uniprot No.:
-
種屬:Mus musculus (Mouse)
-
樣本類型:serum, plasma,tissue homogenates
-
檢測范圍:6.25 pg/mL-400 pg/mL
-
靈敏度:1.56 pg/mL
-
反應時間:1-5h
-
樣本體積:50-100ul
-
檢測波長:450 nm
-
研究領域:Cell Biology
-
測定原理:quantitative
-
測定方法:Sandwich
-
數據處理:
-
貨期:3-5 working days
引用文獻
- Icaritin-curcumol activates CD8+ T cells through regulation of gut microbiota and the DNMT1/IGFBP2 axis to suppress the development of prostate cancer W Xu,Journal of experimental & clinical cancer research,2024
相關產品
靶點詳情
-
功能:Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
-
基因功能參考文獻:
- GzmA and gzmB were predominantly expressed by natural killer cells, and during abdominal sepsis, the percentage of these cells expressing gzms in peritoneal lavage fluid decreased, while the amount of expression in the gzm(+) cells increased PMID: 28694562
- a novel endogenous trigger for autoimmune diabetes and an in vivo role for granzyme A in maintaining immune tolerance. PMID: 28733313
- this study shows that gzmA and gzmB partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae PMID: 26894590
- Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis. PMID: 27055232
- Data indicate N-terminomics on the human and mouse granzymes A and K by combined fractional diagonal chromatography (COFRADIC). PMID: 25383893
- The results, in susceptible B6 mice for GzmB and in resistant 129/Sv mice for GzmA and/or the GzmB cluster, point to granzyme-mediated host defense regulation in the liver in experimental visceral leishmaniasis. PMID: 25452549
- Estrogen increases the extracellular expression and interleukin (IL)-12-induced activity of a critical member of serine protease family granzyme A. PMID: 24840346
- functional divergence between human and mouse granzyme A PMID: 24505135
- We have demonstrated that cell death can be induced when mGzmA is delivered by primary natural killer cells via authentic Cytotoxic lymphocyte/target cell interactions. PMID: 23744295
- Regulated secretion of granzyme A and cytotoxic killing was enhanced and correlated with increased vesicle-associated membrane protein 7 availability. PMID: 23084031
- GzmA deficiency in filarial infection is linked with reduced inflammation and a trend toward increased alternatively activated macrophages. PMID: 21248253
- granzyme A- and B-cluster deficiency delays the acute progression of pneumovirus disease by reducing alveolar injury. PMID: 20018616
- the genes for perforin, the three major T cell granzymes (A-C) and IFN-gamma are differentially expressed during primary activation of naive CD8(+) T cells, kinetically and at the single-cell level PMID: 12039912
- granzyme A and granzyme B have a similar potential to induce rapid perf-mediated apoptosis but that their individual contribution to the underlying intracellular process is dictated by the quality of the target cell PMID: 12115618
- NK cell mediated tumor control is dependent on granzymes. PMID: 12355441
- some cytolytic T lymphocytes mature into perforin/granzyme-expressing effector cells in the mediastinal lymph node and are detectable when they accumulate in lung infection PMID: 12601154
- In all tumor models examined thus far, granzyme A is not necessary for tumor rejection mediated by the perforin pathway in vivo. PMID: 12847210
- gzmA and gzmB induce multiple independent cell death pathways; all gzm-induced apoptotic features analyzed depend critically on perf. PMID: 15534000
- polymorphonuclear leukocytes from mice and humans lack the 3 cytotoxic effector molecules, gzmA, granzyme B, and perforin, generally associated with natural killer and cytotoxic T lymphocytes PMID: 15998831
- IL-2 increased the expression of perforin and granzyme A, B, and C mRNA; induction of granzyme A, B, and C mRNA required exogenous IL-2, whereas induction of perforin and IFN-gamma expression did not. PMID: 16339537
- CTLs from granzyme AB(-/-) mice induce target cell death by a unique mechanism that is distinct from both perforin lysis and apoptosis. PMID: 16606695
- Mouse granzyme B is 30 times less cytotoxic than human granzyme B and does not require Bid for killing but regains cytotoxicity on engineering of its active site cleft. Mouse granzyme A is considerably more cytotoxic than human granzyme A. PMID: 17116752
- Skin-, but not lung-associated primary mast cells as well as in vitro-differentiated bone marrow-derived mast cells (BMMC) express granzyme (gzm) B, but not gzmA or perforin (perf). PMID: 17599099
- GzmA accesses the mitochondrial matrix to cleave the complex I protein NDUFS3, an iron-sulfur subunit of the NADH:ubiquinone oxidoreductase complex I. PMID: 18485875
- grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B. PMID: 18788942
- the granule secretory pathway plays an unexpected role in inflammation, with GzmA acting as an endogenous modulator. PMID: 18951048
- Neither gzmA nor gzmB is required for rapid and efficient in vivo cytotoxicity by cytotoxic T (Tc) cells. PMID: 19525394
顯示更多
收起更多
-
亞細胞定位:Secreted. Cytoplasmic granule.
-
蛋白家族:Peptidase S1 family, Granzyme subfamily
-
組織特異性:Found in cytotoxic lymphocytes and in normal lymphoid tissues such as thymus and spleen.; [Isoform HF1]: More abundant in lymphoid tissues than isoform HF2.
-
數據庫鏈接:
Most popular with customers
-
Human Transforming Growth factor β1,TGF-β1 ELISA kit
Detect Range: 23.5 pg/ml-1500 pg/ml
Sensitivity: 5.8 pg/ml
-
-
-
Mouse Tumor necrosis factor α,TNF-α ELISA Kit
Detect Range: 7.8 pg/ml-500 pg/ml
Sensitivity: 1.95 pg/ml
-
-
-
-