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  4. Mouse monocyte chemotactic protein 2,MCP-2 ELISA kit

Mouse monocyte chemotactic protein 2,MCP-2 ELISA kit

  • 中文名稱：
    小鼠單核細(xì)胞趨化蛋白2(MCP-2/CCL8)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E07428m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠單核細(xì)胞趨化蛋白2(MCP-2/CCL8)酶聯(lián)免疫試劑盒（CSB-E07428m）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的CCL8含量。CCL8是一個(gè)靶點(diǎn)。它屬于趨化因子家族，在炎癥反應(yīng)、免疫調(diào)節(jié)等生理過程中發(fā)揮作用。研究機(jī)制方面，其可與相應(yīng)受體結(jié)合，介導(dǎo)免疫細(xì)胞的遷移和活化，在腫瘤、自身免疫病等疾病進(jìn)展中可能扮演重要角色，是潛在治療靶點(diǎn)。試劑盒檢測(cè)范圍為6.25 pg/mL-400 pg/mL，本試劑盒通過高特異性抗體對(duì)實(shí)現(xiàn)精準(zhǔn)捕獲和信號(hào)放大，適用于小鼠模型中的炎癥機(jī)制研究、免疫調(diào)控實(shí)驗(yàn)或相關(guān)疾病（如自身免疫病、感染性疾?。┑姆肿訕?biāo)志物分析，能夠穩(wěn)定檢測(cè)生物樣本中低至皮克級(jí)別的目標(biāo)蛋白含量，為科研人員探索趨化因子網(wǎng)絡(luò)功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ccl8 ELISA Kit; Mcp2 ELISA Kit; Scya8C-C motif chemokine 8 ELISA Kit; Monocyte chemoattractant protein 2 ELISA Kit; Monocyte chemotactic protein 2 ELISA Kit; MCP-2 ELISA Kit; Small-inducible cytokine A8 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse MCP-2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %87
    Range %85-88
    1:2Average %102
    Range %98-106
    1:4Average %98
    Range %96-101
    1:8Average %92
    Range %89-95
  • 回收率：
    The recovery of mouse MCP-2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8884-92
    EDTA plasma (n=4)9592-98
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    4002.955 2.781 2.868 2.720
    2002.138 2.156 2.147 1.999
    1001.445 1.532 1.489 1.341
    500.921 0.903 0.912 0.764
    250.584 0.561 0.573 0.425
    12.50.333 0.324 0.329 0.181
    6.250.241 0.253 0.247 0.099
    00.142 0.153 0.148
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Chemotactic factor that attracts monocytes. This protein can bind heparin.
  • 基因功能參考文獻(xiàn)：
    1. Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management. PMID: 27181207
    2. these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expression of the chemokine CCL8. PMID: 24477914
    3. Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt signaling pathway. PMID: 23418602
    4. Vitamin B6 supplementation downregulates Cd8a and Ccl8 mRNA expression, so these candidate genes may play a protective role against colonic aberrant crypt foci development. PMID: 22495988
    5. early and preclinical expression of CCL8 in plasma predicts overall survival of graft-vs.-host disease (GVHD) mice. Together with an involvement of allo-recognition in CCL8 expression, it suggests that CCL8 plays an important role in GVHD pathology. PMID: 21782767
    6. MCP/CCL8 was induced via STAT3 and exhibited anti-tumor metastatic effect PMID: 21624767
    7. promotes atopic dermatitis by recruiting IL-5+ Th2 cells PMID: 21217759
    8. CCL8 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli. PMID: 20931267
    9. Data show that that the stromal cell-derived chemokines CXCL12 and CCL8 cooperate to attract hematopoietic progenitors with the potential to differentiate into regulatory DCs. PMID: 20624948
    10. CCL8 is a promising specific serum marker for the early and accurate diagnosis of graft-versus-host disease. PMID: 18256320
    11. An elevated plasma CCL8 concentration may be a promising plasma marker for GVHD in mouse models PMID: 19302923

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 數(shù)據(jù)庫鏈接：