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  4. Mouse serum amyloid A2 (SAA2) ELISA kit

Mouse serum amyloid A2 (SAA2) ELISA kit

  • 中文名稱：
    小鼠血清淀粉樣蛋白A2(SAA2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL020657MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠血清淀粉樣蛋白A2(SAA2)酶聯(lián)免疫試劑盒（CSB-EL020657MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的SAA2含量。SAA2即血清淀粉樣蛋白A2，它與炎癥反應(yīng)密切相關(guān)。在機(jī)體受到感染、損傷等刺激時(shí)表達(dá)上調(diào)。研究機(jī)制方面，主要聚焦于其在炎癥信號(hào)傳導(dǎo)通路中的作用，以及對(duì)免疫細(xì)胞的調(diào)節(jié)，探索其作為炎癥相關(guān)疾病診斷標(biāo)志物和治療靶點(diǎn)的潛力。試劑盒檢測(cè)范圍為7.8 ng/mL-500 ng/mL，適用于基礎(chǔ)科研中炎癥機(jī)制研究、疾病模型動(dòng)態(tài)監(jiān)測(cè)或代謝相關(guān)實(shí)驗(yàn)的生物學(xué)標(biāo)記分析。尤其適合體外實(shí)驗(yàn)如細(xì)胞因子誘導(dǎo)模型、感染性疾病動(dòng)物模型的血清或組織樣本檢測(cè)，為炎癥相關(guān)信號(hào)通路研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    Saa2 ELISA Kit; Serum amyloid A-2 protein [Cleaved into: Amyloid protein A ELISA Kit; Amyloid fibril protein AA)] ELISA Kit
  • 縮寫：
    SAA2
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    7.8 ng/mL-500 ng/mL
  • 靈敏度：
    1.95 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse SAA2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 108
    Range % 98-112
    1:2 Average % 97
    Range % 88-101
    1:4 Average % 90
    Range % 83-94
    1:8 Average % 100
    Range % 90-104
  • 回收率：
    The recovery of mouse SAA2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 102 93-106
    EDTA plasma (n=4) 93 85-97
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    500 1.723 1.835 1.779 1.591
    250 1.277 1.189 1.233 1.045
    125 0.864 0.887 0.876 0.688
    62.5 0.685 0.674 0.680 0.492
    31.2 0.463 0.456 0.460 0.272
    15.6 0.384 0.367 0.376 0.188
    7.8 0.286 0.291 0.289 0.101
    0 0.190 0.186 0.188 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Major acute phase reactant.
  • 基因功能參考文獻(xiàn)：
    1. High level SAA expression induced amyloidosis in all mice after a short, slightly variable delay. PMID: 23959890
    2. These results suggest that the carboxy terminus of SAA, which is highly conserved among SAA sequences in all vertebrates, might play important structural roles, including modulating the folding, oligomerization, misfolding, and fibrillation of SAA.(Saa2) PMID: 22448726
    3. The nonpathogenic murine Saa2.2 spontaneously forms marginally stable amyloid fibrils at 37 degrees C that exhibit cross-beta structure, binding to thioflavin T, and fibrillation by a nucleation-dependent seeding mechanism. PMID: 21942925
    4. The ability of SAA2.2 to form different oligomeric species in vitro along with its marginal stability, suggest that the structure of SAA might be modulated in vivo to form different biologically relevant species. PMID: 21439938
    5. forms a hexamer containing a central channel in solution PMID: 12456883
    6. Only liposomes containing intact SAA2.1 or its residues 1-20 or 74-103 promoted the efflux of cholesterol in vivo PMID: 12951366
    7. SAA2.2 can form amyloid fibrils in vitro at physiological temperatures, which suggests that SAA2.2's inability to cause amyloidosis may be related to the stabilization of hexameric SAA2.2 and/or the slow kinetics of aberrant misfolding and self-assembly. PMID: 16194868
    8. Many functional and pathological roles attributed to serum amyloid A may rely on its precarious structure, modulated by its interaction with ligands under homeostasis conditions and during the acute phase response. PMID: 17425332

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  • 相關(guān)疾?。?/div>
    Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    SAA family
  • 組織特異性：
    Expressed by the liver; secreted in plasma.
  • 數(shù)據(jù)庫(kù)鏈接：