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  4. Mouse sex hormone-binding globulin,SHBG ELISA Kit

Mouse sex hormone-binding globulin,SHBG ELISA Kit

  • 中文名稱(chēng)：
    小鼠性激素結(jié)合球蛋白(SHBG)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E08233m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠性激素結(jié)合球蛋白(SHBG)酶聯(lián)免疫試劑盒（CSB-E08233m）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿樣本中的SHBG含量。SHBG即性激素結(jié)合球蛋白，它能特異性結(jié)合雄激素和雌激素，調(diào)控性激素在體內(nèi)的活性。近年來(lái)研究發(fā)現(xiàn)其與多種疾病相關(guān)，如多囊卵巢綜合征、代謝綜合征等。深入研究其作用機(jī)制，或可助力相關(guān)疾病的早期診斷、病情評(píng)估及治療靶點(diǎn)開(kāi)發(fā)。試劑盒檢測(cè)范圍為1.3 ng/mL-50 ng/mL，適用于研究性激素代謝調(diào)控機(jī)制、生殖系統(tǒng)疾病模型構(gòu)建、內(nèi)分泌干擾物評(píng)估等基礎(chǔ)科研場(chǎng)景，可滿(mǎn)足實(shí)驗(yàn)室對(duì)小鼠生殖內(nèi)分泌相關(guān)研究的定量檢測(cè)需求，為探索激素依賴(lài)性生理病理過(guò)程提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Shbg ELISA Kit; Sex hormone-binding globulin ELISA Kit; SHBG ELISA Kit; Sex steroid-binding protein ELISA Kit; SBP ELISA Kit; Testis-specific androgen-binding protein ELISA Kit; ABP ELISA Kit
  • 縮寫(xiě)：
    SHBG
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類(lèi)型：
    serum, plasma
  • 檢測(cè)范圍：
    1.3 ng/mL-50 ng/mL
  • 靈敏度：
    0.33 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<15%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse SHBG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %91
    Range %86-97
    1:2Average %97
    Range %92-103
    1:4Average %85
    Range %81-90
    1:8Average %89
    Range %83-95
  • 回收率：
    The recovery of mouse SHBG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9187-95
    EDTA plasma (n=4)109104-114
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    502.344 2.491 2.418 2.370
    271.768 1.822 1.795 1.747
    131.003 1.042 1.023 0.975
    3.30.376 0.365 0.371 0.323
    1.30.175 0.189 0.182 0.134
    00.046 0.049 0.048
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
  • 基因功能參考文獻(xiàn)：
    1. SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome PMID: 30046278
    2. A wave of apoptosis during the pre-pubertal period is required for normal spermatogenesis to develop, and our data indicate that this apoptotic wave may be regulated by ABP and/or androgens. PMID: 12831397
    3. USF transcription factors repress SHBG transcription in Sertoli cells through an interaction with FP4 within its proximal promoter PMID: 15574421
    4. monosaccharide-induced lipogenesis reduced hepatic HNF-4alpha levels, which in turn attenuated SHBG expression. PMID: 17992261
  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:20415

    STRING: 10090.ENSMUSP00000005334

    UniGene: Mm.1431