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  4. Mouse soluble Triggering Receptor Expresses on Myeloid Cells-1,sTREM-1 ELISA Kit

Mouse soluble Triggering Receptor Expresses on Myeloid Cells-1,sTREM-1 ELISA Kit

  • 中文名稱：
    小鼠可溶性髓系細(xì)胞觸發(fā)受體-1(sTREM-1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E13848m
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠可溶性髓系細(xì)胞觸發(fā)受體-1(sTREM-1)酶聯(lián)免疫試劑盒（CSB-E13848m）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的TREM1含量。TREM1（髓系細(xì)胞觸發(fā)受體 1）是一個(gè)重要靶點(diǎn)。它主要在髓系細(xì)胞表達(dá)，參與炎癥反應(yīng)調(diào)控。研究發(fā)現(xiàn)其激活后能放大炎癥信號(hào)，加劇炎癥反應(yīng)。深入研究 TREM1 機(jī)制有助于理解炎癥性疾病發(fā)病機(jī)制，為相關(guān)疾病治療提供新方向。試劑盒檢測(cè)范圍為15.6 pg/mL-1000 pg/mL，可為研究者開展炎癥機(jī)制研究、藥物療效評(píng)估或疾病模型構(gòu)建提供穩(wěn)定可靠的數(shù)據(jù)支持，尤其適用于膿毒癥小鼠模型、呼吸道感染模型及免疫調(diào)控相關(guān)實(shí)驗(yàn)的生物標(biāo)志物分析。本產(chǎn)品僅限于科學(xué)研究使用。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Trem1 ELISA Kit; Triggering receptor expressed on myeloid cells 1 ELISA Kit; TREM-1 ELISA Kit; CD antigen CD354 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse sTREM-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %94
    Range %86-99
    1:2Average %98
    Range %90-102
    1:4Average %92
    Range %85-96
    1:8Average %98
    Range %92-101
  • 回收率：
    The recovery of mouse sTREM-1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9084-94
    EDTA plasma (n=4)10091-105
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    10002.657 2.542 2.600 2.470
    5002.038 2.089 2.064 1.934
    2501.363 1.414 1.389 1.259
    1250.756 0.788 0.772 0.642
    62.50.463 0.454 0.459 0.329
    31.30.321 0.313 0.317 0.187
    15.60.256 0.266 0.261 0.131
    00.132 0.128 0.130
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.
  • 基因功能參考文獻(xiàn)：
    1. Results suggest that aggravation of VILI by TREM-1 in mice may be associated with TLR4-MyD88-NF-kappaB-dependent signaling. PMID: 29869715
    2. Study using a mouse model of oxygen-induced retinopathy found that TREM-1 inhibition substantially downregulated retinal protein levels of TREM-1 and M-CSF suggesting that TREM-1-dependent suppression of pathological angiogenesis involves M-CSF. PMID: 29730341
    3. TREM-1 is a predictive biomarker of in-stent restenosis and an important mediator of cellular inflammation, migration, and proliferation in vascular smooth muscle cells PMID: 29080545
    4. TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis. PMID: 27762264
    5. TREM-1 aggravates inflammation in acute lung injury by activating NLRP3 inflammasome, and blocking TREM-1 may be a potential therapeutic approach for acute lung injury PMID: 28004759
    6. TREM-1 interventions by means of LP17, LR12 and TREM-1 fusion protein did not ameliorate IR-induced injury. In the human renal transplant cohort, donor and recipient TREM1 gene variant p.Thr25Ser was not associated with DGF, nor with biopsy-proven rejection or death-censored graft failure. We conclude that TREM-1 does not play a major role during experimental renal IR and after kidney transplantation PMID: 27928159
    7. TREM-1 plays an important role in mediating platelet activation. PMID: 28837205
    8. Experimental viral hepatitis induced by infection with Lymphocytic Choriomeningitis Virus (LCMV)-WE associated with increased TREM1 in serum and urine, and with increased TREM1 and its associated adapter molecule DAP12 in the liver. Trem1-/- mice showed accelerated clearance of LCMV-WE and manifested attenuated liver inflammation and injury. PMID: 27328755
    9. no significant effect on the severity of psoriasis PMID: 26782119
    10. low expression level of TREM-1 might be a characteristic for tumor-associated macrophages in lung cancer PMID: 27244892
    11. Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus. PMID: 28089248
    12. these data suggested that TREM-1 signaling pathway may be a therapeutic target to prevent the effects of the inflammatory dendritic cells in systemic lupus erythematosus and miRNA-150 serves as the important regulator PMID: 27940256
    13. The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion PMID: 27568523
    14. This study is the first to show the regulatory role of TREM-1 in RLRs and TLRs expression. PMID: 27237091
    15. TREM-1 is upregulated in renal inflammation and plays a vital role in driving disease. Thus, TREM-1 blockade emerges as a potential therapeutic avenue for immune-mediated renal diseases such as lupus nephritis PMID: 27083877
    16. in macrophages, oxidized low-density lipoprotein enhanced expression of TREM-1, which amplifies the innate immune response of Toll-like receptor pathway; activation of TREM-1 contributes to atherogenesis process by enhancing proinflammatory cytokine production and foam cell formation. PMID: 26277357
    17. High Expression Levels of Trigger Receptor Expressed on Myeloid Cells-1 on Neutrophils Associated with Increased Severity of Acute Pancreatitis in Mice PMID: 26250893
    18. a novel positive feedback cycle mediated by TREM-1 and GM-CSF was revealed to enhance macrophage polarization under unilateral ureteral obstruction. PMID: 24918157
    19. TREM-1-mediated innate immune response played an essential role in the activation of neutrophils and Streptococcus suis clearance. PMID: 26056380
    20. Data indicate that triggering receptor expressed on myeloid cells-1(TREM-1) inhibition improves heart function after myocardial infarction (MI). PMID: 25840803
    21. TREM-1 is significantly associated with LPS-induced left ventricular systolic dysfunction in BALB/c mice PMID: 24959004
    22. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PMID: 24453980
    23. Data indicate that triggering receptor expressed on myeloid cells 1 (TREM-1) induces anti-apoptotic protein Bcl-2 and prolongs macrophage survival. PMID: 24711453
    24. Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia. PMID: 24752755
    25. expression of membrane and soluble form is regulated by TLR9 activation with CpG-ODN PMID: 23475790
    26. Data indicate a positive correlation between serum levels of soluble TREM-1 (sTREM-1) and disease severity in infected patients as well as in experimentally infected mice. PMID: 23571837
    27. TREM-1-mediated bacterial clearance in the small intestine. PMID: 24396044
    28. TREM-1 plays critical roles in colon inflammation and tumor. PMID: 23810411
    29. TREM-1 influences chronic heart rejection by regulating the infiltration and differentiation of CD4(+) lymphocytes. PMID: 23463907
    30. These data define a new function for TREM-1 in neutrophil migration across airway epithelial cells and suggest that it amplifies inflammation through targeted neutrophil migration into the lung. PMID: 23241959
    31. Findings offer causal evidence that TREM-1 is a pivotal determinant of Kupffer cell activation in liver carcinogenesis, deepening mechanistic insights into how chronic inflammation underpins the development and progression of liver cancer. PMID: 22719066
    32. TREM-1 was not expressed on lymphocytes but emerged on the cell surface of neutrophils and peritoneal macrophages. PMID: 22055202
    33. TREM-1 modulates the immune response directed against A. fumigatus during experimental fungal asthma. PMID: 21592044
    34. The present study has demonstrated for the first time the detailed mechanism for the basal and LPS-induced expression of TREM-1, an amplifying molecule in inflammation. PMID: 21683719
    35. this study provides the fi rst evidence that TREM-1 functions as an in fl ammatory ampli fi er in P. aeruginosa keratitis by modulating TLR signaling and Th1/Th2 responses. PMID: 21555403
    36. In this study, the authors delineate the role of the innate immunoreceptor TREM-1 in the parasite Schistosoma mansoni infection model from early to late (chronic) phases of infection. PMID: 21332515
    37. Calcitonin gene-related peptide can regulate the LPS-induced macrophages synthesis and secretion of TREM-1. PMID: 20197606
    38. The expression of TREM-1 in response to lipopolysaccharides and bacteria Pseudomonas aeruginosa is inhibited by PGD(2) and cyclopentanone prostaglandins PGJ(2) and 15-dPGJ(2). PMID: 20797396
    39. crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution PMID: 15561137
    40. Regulation of TREM-1 and the soluble form of TREM-1 expression by prostaglandin E2 may modulate the inflammatory response to microbial pathogens PMID: 17202378
    41. septic shock induced could be attenuated by administering a Trem1-Fc fusion protein PMID: 19120482
    42. TREM-1 ligation contributes to the pathology of autoimmune arthritis. PMID: 19479878
    43. TREM-1 enhances responsiveness of alveolar macrophages to S. pneumoniae in vitro, and augments the early pulmonary inflammatory response PMID: 19596984

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫(kù)鏈接：