Mouse thrombospondin 1,TSP-1 ELISA Kit
產(chǎn)品詳情
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產(chǎn)品描述:
小鼠血小板反應(yīng)蛋白/凝血酶敏感蛋白1(TSP-1)酶聯(lián)免疫試劑盒(CSB-E08765m)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的THBS1含量。小鼠血小板反應(yīng)蛋白/凝血酶敏感蛋白1(TSP-1)是一種多功能細(xì)胞外基質(zhì)糖蛋白,參與血管生成、炎癥反應(yīng)和細(xì)胞遷移等生物學(xué)過程。其在腫瘤發(fā)生發(fā)展中起到重要作用,通過調(diào)節(jié)腫瘤新生血管生成,影響腫瘤的生長、侵襲和轉(zhuǎn)移。TSP-1的研究機(jī)制涉及多種信號(hào)通路,如mTOR信號(hào)通路,以及與CD47等受體的相互作用。試劑盒檢測范圍為3.12 ng/ml-200 ng/ml,靈敏度為1.56 ng/ml。適用于體外研究中小鼠模型的血漿、血清樣本分析,或特定組織(如肝臟、血管等)勻漿中TSP - 1的表達(dá)水平檢測。其高特異性和穩(wěn)定性使其成為探究TSP - 1在血管生成調(diào)控、纖維化進(jìn)程或腫瘤免疫微環(huán)境等科研方向中的可靠工具,為分子機(jī)制研究及藥物開發(fā)提供數(shù)據(jù)支持。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名:
Thbs1 ELISA Kit; Tsp1 ELISA Kit; Thrombospondin-1 ELISA Kit; Glycoprotein G ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:
Mus musculus (Mouse)
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樣本類型:
serum, plasma, tissue homogenates
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檢測范圍:
3.12 ng/ml-200 ng/ml
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靈敏度:
1.56 ng/ml
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反應(yīng)時(shí)間:
1-5h
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樣本體積:
50-100ul
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檢測波長:
450 nm
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研究領(lǐng)域:
Cardiovascular
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測定原理:
quantitative
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測定方法:
Sandwich
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本試劑盒不含材料:
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數(shù)據(jù)處理:
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貨期:
3-5 working days
引用文獻(xiàn)
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Approaching Thrombospondin-1 as a Potential Target for Mesenchymal Stromal Cells to Support Liver Regeneration after Partial Hepatectomy in Mouse and Humans
L Tietze,Cells,2024
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The Effect of Metformin in EML4-ALK+ Lung Cancer alone and in Combination with Crizotinib in Cell and Rodent Models
AR Bland,Biochemical Pharmacology,2020
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Mouse skin-derived precursors alleviates ultraviolet B irradiation damage via early activation of TGF-β/Smad pathway by thrombospondin1
Y Li,Cell Cycle,2020
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Endothelial MT1-MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis
Esteban S, et al,Embo Molecular Medicine,2019
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Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin
Fossati G, et al,Embo Journal,2018
靶點(diǎn)詳情
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最新研究進(jìn)展:
THBS1是一種血小板聚集素,最近的研究表明它在腫瘤生長和轉(zhuǎn)移中發(fā)揮著重要作用。研究表明,THBS1可以促進(jìn)血管生成和癌細(xì)胞的增殖,并與癌細(xì)胞的生長和轉(zhuǎn)移有關(guān)。此外,THBS1還參與了許多其他疾病的發(fā)生和發(fā)展,包括動(dòng)脈粥樣硬化、肝病和神經(jīng)退行性疾病等。
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功能:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors.
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亞細(xì)胞定位:
Secreted. Cell surface. Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum. Sarcoplasmic reticulum.
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蛋白家族:
Thrombospondin family
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數(shù)據(jù)庫鏈接:
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