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  4. Pig monocyte chemotactic protein 1,MCP1 ELISA Kit

Pig monocyte chemotactic protein 1,MCP1 ELISA Kit

  • 中文名稱：
    豬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13178p
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥4200/￥3000
  • 其他：

產品詳情

  • 產品描述：
    豬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒（CSB-E13178p）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的CCL2含量。CCL2是重要的趨化因子。它能招募單核細胞、記憶性T淋巴細胞等至炎癥部位，在炎癥反應、免疫調節(jié)等過程中發(fā)揮關鍵作用。研究發(fā)現(xiàn)其與腫瘤發(fā)生發(fā)展、神經(jīng)退行性疾病等相關，圍繞其機制的研究旨在為相關疾病治療提供新思路。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，廣泛應用于動物疾病模型研究、免疫調控機制探索及炎癥相關分子通路分析，例如豬病毒感染、細菌性肺炎等病理過程中單核細胞趨化活性的動態(tài)監(jiān)測。本品僅用于科研，不用于臨床診斷，產品具體參數(shù)及操作步驟詳見產品說明書。
  • 別名：
    CCL2 ELISA Kit; SCYA2C-C motif chemokine 2 ELISA Kit; Monocyte chemoattractant protein 1 ELISA Kit; Monocyte chemotactic protein 1 ELISA Kit; MCP-1 ELISA Kit; Small-inducible cytokine A2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Sus scrofa (Pig)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of pig MCP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %92
    Range %87-96
    1:2Average %98
    Range %93-102
    1:4Average %85
    Range %81-89
    1:8Average %96
    Range %93-99
  • 回收率：
    The recovery of pig MCP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9188-96
    EDTA plasma (n=4)8580-90
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    20002.078 2.069 2.074 1.880
    10001.610 1.687 1.649 1.455
    5001.099 1.059 1.079 0.885
    2500.615 0.638 0.627 0.433
    1250.427 0.438 0.433 0.239
    62.50.342 0.349 0.346 0.152
    31.250.276 0.268 0.272 0.078
    00.189 0.198 0.194
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
  • 基因功能參考文獻：
    1. these results provide novel insights into CCL2-mediated signaling mechanisms in the porcine endometrium at the maternal-fetal interface during early pregnancy PMID: 29278679
    2. CXCL10 protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate. PMID: 24083897
    3. Porcine CCL2 binding on Tuk4+SLA-II- but not on Tuk4-SLA-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein. PMID: 20670605
    4. The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling. PMID: 20580034
    5. MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment PMID: 19730125
    6. may contribute to xenograft rejection by attracting monocytes into the islets PMID: 14962280
    7. Contrast media did not affect bone marrow cell viability/MCP-1 secretion. PMID: 15274157
    8. Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern. PMID: 16926016
    9. in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta PMID: 17588585
    10. Variable gene expression (eg, matrix metalloproteinase-9, CCL2 and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression. PMID: 18276914
    11. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP PMID: 19036073

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 數(shù)據(jù)庫鏈接：

    KEGG: ssc:397422

    STRING: 9823.ENSSSCP00000018779

    UniGene: Ssc.657