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  4. Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit

Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit

  • 中文名稱：
    大鼠晚期糖基化終產(chǎn)物特異性受體(AGER)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL001441RA
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠晚期糖基化終產(chǎn)物特異性受體(AGER)酶聯(lián)免疫試劑盒（CSB-EL001441RA）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿,組織勻漿樣本中的AGER含量。AGER即晚期糖基化終末產(chǎn)物受體，在炎癥、氧化應(yīng)激等病理過程發(fā)揮重要作用。研究顯示，它可與多種配體結(jié)合，激活下游信號(hào)通路，引發(fā)細(xì)胞內(nèi)一系列反應(yīng)，參與糖尿病并發(fā)癥、神經(jīng)退行性疾病、腫瘤等疾病發(fā)生發(fā)展，是潛在治療靶點(diǎn)。試劑盒檢測(cè)范圍為31.25 pg/mL-2000 pg/mL，靈敏度為7.81 pg/mL。該產(chǎn)品主要應(yīng)用于基礎(chǔ)研究領(lǐng)域，如糖尿病相關(guān)器官損傷的分子機(jī)制探索、神經(jīng)炎癥模型的蛋白表達(dá)分析，或藥物干預(yù)下AGER信號(hào)通路變化的體外評(píng)估，為科研人員提供可靠的實(shí)驗(yàn)工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ager ELISA Kit; Rage ELISA Kit; Advanced glycosylation end product-specific receptor ELISA Kit; Receptor for advanced glycosylation end products ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測(cè)范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

    　

    Intra-Assay Precision

    Inter-Assay Precision

    Sample

    1

    2

    3

    1

    2

    3

    n

    20

    20

    20

    20

    20

    20

    Mean(pg/ml)

    224.423

    224.423

    225.339

    224.377

    225.431

    224.881

    SD

    0.034

    0.030

    0.031

    0.040

    0.037

    0.039

    CV(%)

    4.433

    3.911

    4.031

    5.216

    4.810

    5.078

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of rat AGER in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    92

    Range %

    90-94

    1:2

    Average %

    96

    Range %

    90-102

    1:4

    Average %

    102

    Range %

    99-105

    1:8

    Average %

    87

    Range %

    80-94

  • 回收率：

    The recovery of rat AGER spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    90

    87-95

    EDTA plasma (n=4)

    101

    97-106

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    2000

    2.703

    2.878

    2.791

    2.615

    1000

    1.903

    1.856

    1.880

    1.704

    500

    1.245

    1.154

    1.200

    1.024

    250

    0.731

    0.747

    0.739

    0.563

    125

    0.556

    0.533

    0.545

    0.369

    62.5

    0.402

    0.392

    0.397

    0.221

    31.25

    0.272

    0.275

    0.274

    0.098

    0

    0.173

    0.179

    0.176

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
        最新研究發(fā)現(xiàn)，AGER基因的多態(tài)性可能與各種疾病的發(fā)生有關(guān)，包括糖尿病、肺炎、慢性阻塞性肺病等。此外，AGER的表達(dá)也與肺癌、乳腺癌、胃癌等腫瘤的發(fā)生和發(fā)展有關(guān)。
     
  • 功能：
    Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Endothelial cells and cardiomyocytes.
  • 數(shù)據(jù)庫(kù)鏈接：