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  4. Rat Apolipoprotein A5(apo-A5)ELISA Kit

Rat Apolipoprotein A5(apo-A5)ELISA Kit

  • 中文名稱：
    大鼠載脂蛋白A5(apo-A5)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E16334r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠載脂蛋白A5(apo-A5)酶聯(lián)免疫試劑盒（CSB-E16334r）為競爭法ELISA試劑盒，定量檢測樣本中的APOA5含量。APOA5是一個(gè)重要靶點(diǎn)。它在脂質(zhì)代謝中起關(guān)鍵作用，其表達(dá)水平與甘油三酯濃度密切相關(guān)。研究機(jī)制方面，主要圍繞其調(diào)控脂蛋白代謝過程展開，通過影響載脂蛋白功能等方式，在心血管疾病等相關(guān)疾病研究中備受關(guān)注。本產(chǎn)品適用于科研領(lǐng)域研究apo - A5在脂質(zhì)代謝調(diào)控中的作用機(jī)制；本產(chǎn)品可為研究脂代謝紊亂動(dòng)物模型、藥物干預(yù)效果評(píng)價(jià)或基因表達(dá)調(diào)控實(shí)驗(yàn)提供可靠的檢測工具，廣泛應(yīng)用于心血管疾病、代謝綜合征等領(lǐng)域的機(jī)制探索。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Apoa5 ELISA kit; Rap3Apolipoprotein A-V ELISA kit; Apo-AV ELISA kit; ApoA-V ELISA kit; Apolipoprotein A5 ELISA kit; Regeneration-associated protein 3 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
  • 檢測范圍：
  • 靈敏度：
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 精密度：
     
  • 線性度：
     
  • 回收率：
     
  • 標(biāo)準(zhǔn)曲線：
     
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
        APOA5是一種與三酰甘油代謝和心血管疾病風(fēng)險(xiǎn)密切相關(guān)的蛋白。最新的研究表明，APOA5可能還具有調(diào)節(jié)肝細(xì)胞脂代謝和炎癥反應(yīng)的作用。一項(xiàng)發(fā)表在Journal of Lipid Research上的研究發(fā)現(xiàn)，APOA5通過調(diào)節(jié)脂代謝酶基因的表達(dá)，影響肝臟脂質(zhì)代謝和三酰甘油的水平。此外，一些研究還發(fā)現(xiàn)，APOA5與胰島素抵抗、非酒精性脂肪肝等疾病有關(guān)。
  • 功能：
    Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.
  • 基因功能參考文獻(xiàn)：
    1. Our data support the hypothesis that apoA5 promotes hepatic TG storage and therefore contributes to the pathogenesis of non-alcoholic fatty liver disease PMID: 25938357
    2. Demonstrate that apoA-V is secreted into bile, introducing a potential route of delivery of hepatic apoA-V to the gut lumen. PMID: 26505974
    3. The increase in apolipoprotein A mRNA induced by rosiglitazone is not directly mediated by peroxisome proliferator-activated receptor gamma.[apolipoprotein av] PMID: 16570166
    4. apoA-V inefficiently traffics within the secretory pathway, that its intracellular itinerary can be regulated by changes in cellular TG accumulation, and that apoA-V synthesis can modulate VLDL TG mobilization and secretion. PMID: 21115968
    5. decreased apolipoprotein A5 is implicated in insulin resistance-related hypertriglyceridemia in obesity PMID: 20047745
    6. ApoA-V ability to enhance insulin secretion in beta-cells and provide evidence of an internalization pathway involving the midkine as partner. PMID: 19910685
    7. the hypotriglyceridemic gene APOA5 is regulated by thyroid hormone PMID: 15941710
    8. The absence of significant changes in Apoa5 gene expression during chronic fructose-induced triglyceride elevation excludes its major role in mechanisms compensating severe hypertriglyceridemia PMID: 16238453
    9. data suggest that the C terminus of apoA-V is essential for lipid droplet association in transfected hepatoma cells and lipoprotein association in conditioned medium while the signal peptide is required for extracellular trafficking of this protein. PMID: 18450648

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  • 亞細(xì)胞定位：
    Secreted. Early endosome. Late endosome. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Apolipoprotein A1/A4/E family
  • 組織特異性：
    Liver.
  • 數(shù)據(jù)庫鏈接：