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  4. Rat Bone morphogenetic protein 4,BMP-4 ELISA Kit

Rat Bone morphogenetic protein 4,BMP-4 ELISA Kit

  • 中文名稱(chēng)：
    大鼠骨成型蛋白4(BMP-4)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E04511r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠骨成型蛋白4(BMP-4)酶聯(lián)免疫試劑盒（CSB-E04511r）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的BMP4含量。BMP4，即骨形態(tài)發(fā)生蛋白4，是TGF-β超家族成員，具有促進(jìn)成骨、血管生成、胚胎分化和神經(jīng)干細(xì)胞分化等功能。其研究背景涉及心血管疾病、骨再生和腫瘤生長(zhǎng)等，機(jī)制上通過(guò)調(diào)節(jié)細(xì)胞增殖、分化和遷移等過(guò)程發(fā)揮作用。試劑盒檢測(cè)范圍為7.8 pg/mL-500 pg/mL，本試劑盒適用于科研領(lǐng)域中對(duì)BMP - 4功能機(jī)制的探索，例如骨骼發(fā)育動(dòng)態(tài)研究、再生醫(yī)學(xué)中組織修復(fù)模型的分子機(jī)制解析、胚胎發(fā)育過(guò)程中形態(tài)發(fā)生調(diào)控的定量分析，以及相關(guān)疾病模型的分子標(biāo)志物檢測(cè)。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Bmp4 ELISA Kit; Bmp-4 ELISA Kit; Dvr-4Bone morphogenetic protein 4 ELISA Kit; BMP-4 ELISA Kit; Bone morphogenetic protein 2B ELISA Kit; BMP-2B ELISA Kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類(lèi)型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    7.8 pg/mL-500 pg/mL
  • 靈敏度：
    1.95 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線(xiàn)性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat BMP-4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %98
    Range %94-105
    1:2Average %91
    Range %85-97
    1:4Average %86
    Range %82-90
    1:8Average %94
    Range %90-100
  • 回收率：
    The recovery of rat BMP-4 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8985-93
    EDTA plasma (n=4)9287-98
  • 標(biāo)準(zhǔn)曲線(xiàn)：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1OD2AverageCorrected
    5002.514 2.651 2.583 2.468
    2501.867 1.797 1.832 1.717
    1251.279 1.315 1.297 1.182
    62.50.885 0.842 0.864 0.749
    31.20.513 0.538 0.526 0.411
    15.60.294 0.289 0.292 0.177
    7.80.201 0.213 0.207 0.092
    00.112 0.118 0.115
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response.
  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    TGF-beta family
  • 數(shù)據(jù)庫(kù)鏈接：