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  4. Rat Chitinase-3-like protein 1(CHI3L1) ELISA kit

Rat Chitinase-3-like protein 1(CHI3L1) ELISA kit

  • 中文名稱：
    大鼠幾丁質(zhì)酶3樣蛋白1(CHI3L1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL005346RA
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠幾丁質(zhì)酶3樣蛋白1(CHI3L1)酶聯(lián)免疫試劑盒（CSB-EL005346RA）檢測(cè)血清、血漿、組織勻漿樣本中的CHI3L1含量。CHI3L1是一個(gè)重要靶點(diǎn)。它與多種疾病發(fā)生發(fā)展相關(guān)，如炎癥、腫瘤等。研究機(jī)制上，其可能通過參與細(xì)胞增殖、遷移、凋亡等過程，影響疾病進(jìn)程，目前圍繞它開展的研究有助于深入理解疾病發(fā)病機(jī)理，為相關(guān)疾病治療提供新思路。試劑盒檢測(cè)范圍為4.7 ng/ml- 300 ng/ml，靈敏度為1.17 ng/ml。研究呼吸系統(tǒng)疾病、肝纖維化及腫瘤微環(huán)境等病理機(jī)制；炎癥相關(guān)疾病模型構(gòu)建、纖維化進(jìn)程評(píng)估及藥物干預(yù)效果研究；探索CHI3L1在生理病理過程中的分子機(jī)制本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Chi3l1Chitinase-3-like protein 1 ELISA kit; Cartilage glycoprotein 39 ELISA kit; CGP-39 ELISA kit; GP-39 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    4.7 ng/ml - 300 ng/ml
  • 靈敏度：
    1.17 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of rat CHI3L1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    103

    Range %

    99-108

    1:2

    Average %

    98

    Range %

    94-102

    1:4

    Average %

    93

    Range %

    89-97

    1:8

    Average %

    90

    Range %

    86-98

  • 回收率：

    The recovery of rat CHI3L1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    95

    90-100

    EDTA plasma (n=4)

    89

    84-95

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    300

    2.486

    2.358

    2.422

    2.241

    150

    2.043

    1.931

    1.987

    1.806

    75

    1.241

    1.329

    1.285

    1.104

    37.5

    0.765

    0.803

    0.784

    0.603

    18.75

    0.413

    0.427

    0.420

    0.239

    9.4

    0.339

    0.345

    0.342

    0.161

    4.7

    0.231

    0.224

    0.228

    0.047

    0

    0.180

    0.182

    0.181

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
  • 基因功能參考文獻(xiàn)：
    1. Results showed that protein and mRNA levels of CHI3L1 decreased in normal cartilage but increased in osteoarthritic cartilage. PMID: 26978347
    2. NGF-treated tissue showed increased expression of CHI3L1 which was inhibited by the presence of Ro 08-2750 in intervertebral disk cells. PMID: 25062286
    3. Data show that hepatic CD14+ cells are an YKL-40(Chi3L1)mRNA and protein source in acute and chronic liver injury, with expression patterns similar to growth factors implicated in inflammation-fibrogenesis PMID: 21987626
  • 亞細(xì)胞定位：
    Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
  • 蛋白家族：
    Glycosyl hydrolase 18 family
  • 數(shù)據(jù)庫鏈接：