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Rat Cluster of Differentiation 63(CD63) ELISA Kit

  • 中文名稱(chēng):
    大鼠CD63分子酶聯(lián)免疫試劑盒
  • 貨號(hào):
    CSB-E14117r
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    大鼠CD63分子酶聯(lián)免疫試劑盒(CSB-E14117r)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿樣本中的CD63含量。CD63是一種跨膜糖蛋白,屬四次跨膜蛋白超家族成員。它在多種細(xì)胞的膜表面表達(dá),具有參與細(xì)胞黏附、遷移等功能。研究機(jī)制上,其可能通過(guò)與其他分子相互作用,參與細(xì)胞內(nèi)信號(hào)傳導(dǎo)過(guò)程,在腫瘤轉(zhuǎn)移、免疫調(diào)節(jié)等領(lǐng)域是研究熱點(diǎn)。試劑盒檢測(cè)范圍為62.5 pg/mL-4000 pg/mL,適用于神經(jīng)退行性疾病模型、腫瘤微環(huán)境分析、炎癥機(jī)制研究等科研場(chǎng)景,為探索CD63在細(xì)胞外囊泡分泌、血小板活化或病理狀態(tài)下的功能調(diào)控提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名:
    Cd63; CD63 antigen; Mast cell antigen AD1; CD antigen CD63
  • 縮寫(xiě):
    CD63
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 樣本類(lèi)型:
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍:
    62.5 pg/mL-4000 pg/mL
  • 靈敏度:
    15.6 pg/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測(cè)波長(zhǎng):
    450 nm
  • 研究領(lǐng)域:
    Immunology
  • 測(cè)定原理:
    quantitative
  • 測(cè)定方法:
    Sandwich
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
  • 基因功能參考文獻(xiàn):
    1. involved in extracellular matrix-basolateral membrane interactions PMID: 15504731
  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, extracellular exosome. Cell surface.
  • 蛋白家族:
    Tetraspanin (TM4SF) family
  • 組織特異性:
    Detected in mast cells and platelets (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接: