Rat Cluster of Differentiation 63(CD63) ELISA Kit
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中文名稱(chēng):大鼠CD63分子酶聯(lián)免疫試劑盒
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貨號(hào):CSB-E14117r
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規(guī)格:96T/48T
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價(jià)格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:大鼠CD63分子酶聯(lián)免疫試劑盒(CSB-E14117r)為雙抗夾心法ELISA試劑盒,定量檢測(cè)血清、血漿、組織勻漿樣本中的CD63含量。CD63是一種跨膜糖蛋白,屬四次跨膜蛋白超家族成員。它在多種細(xì)胞的膜表面表達(dá),具有參與細(xì)胞黏附、遷移等功能。研究機(jī)制上,其可能通過(guò)與其他分子相互作用,參與細(xì)胞內(nèi)信號(hào)傳導(dǎo)過(guò)程,在腫瘤轉(zhuǎn)移、免疫調(diào)節(jié)等領(lǐng)域是研究熱點(diǎn)。試劑盒檢測(cè)范圍為62.5 pg/mL-4000 pg/mL,適用于神經(jīng)退行性疾病模型、腫瘤微環(huán)境分析、炎癥機(jī)制研究等科研場(chǎng)景,為探索CD63在細(xì)胞外囊泡分泌、血小板活化或病理狀態(tài)下的功能調(diào)控提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名:Cd63; CD63 antigen; Mast cell antigen AD1; CD antigen CD63
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縮寫(xiě):CD63
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Uniprot No.:
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種屬:Rattus norvegicus (Rat)
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樣本類(lèi)型:serum, plasma, tissue homogenates
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檢測(cè)范圍:62.5 pg/mL-4000 pg/mL
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靈敏度:15.6 pg/mL
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反應(yīng)時(shí)間:1-5h
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樣本體積:50-100ul
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檢測(cè)波長(zhǎng):450 nm
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研究領(lǐng)域:Immunology
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測(cè)定原理:quantitative
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測(cè)定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
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基因功能參考文獻(xiàn):
- involved in extracellular matrix-basolateral membrane interactions PMID: 15504731
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亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, extracellular exosome. Cell surface.
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蛋白家族:Tetraspanin (TM4SF) family
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組織特異性:Detected in mast cells and platelets (at protein level).
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數(shù)據(jù)庫(kù)鏈接:
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