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  4. Rat Eotaxin 1 (Eotaxin 1/CCL11/ECF)ELISA Kit

Rat Eotaxin 1 (Eotaxin 1/CCL11/ECF)ELISA Kit

  • 中文名稱：
    大鼠嗜酸粒細(xì)胞趨化蛋白Eotaxin 1(Eotaxin 1/CCL11)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E07319r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠嗜酸粒細(xì)胞趨化蛋白Eotaxin 1(Eotaxin 1/CCL11)酶聯(lián)免疫試劑盒（CSB-E07319r）檢測(cè)血清、血漿、組織勻漿樣本中的CCL11含量。CCL11是一種重要的靶點(diǎn)。它在免疫調(diào)節(jié)等生理過程中發(fā)揮作用。相關(guān)研究關(guān)注其在炎癥反應(yīng)、趨化免疫細(xì)胞遷移等機(jī)制，探索其在疾病如過敏性疾病、神經(jīng)系統(tǒng)疾病等發(fā)病中的作用，有望為開發(fā)針對(duì)CCL11的治療手段提供依據(jù)。試劑盒檢測(cè)范圍為15.6 pg/ml-1000 pg/ml，適用于呼吸道疾病模型研究、炎癥機(jī)制探索及藥物干預(yù)效果評(píng)估等科研場(chǎng)景本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ccl11 ELISA Kit; Scya11Eotaxin ELISA Kit; C-C motif chemokine 11 ELISA Kit; Eosinophil chemotactic protein ELISA Kit; Small-inducible cytokine A11 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    15.6 pg/ml -1000 pg/ml
  • 靈敏度：
    3.9 pg/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

  • 線性度：

  • 回收率：

  • 標(biāo)準(zhǔn)曲線：

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils. Binds to CCR3.
  • 基因功能參考文獻(xiàn)：
    1. our data suggest that the CCL11-CCR3 interaction mainly activates PI3K/Akt signal transduction pathway in HUVECs. PMID: 28279120
    2. Iddm30 controls pancreatic expression of Ccl11 (Eotaxin) and the Th1/Th2 balance within the insulitic lesions. PMID: 24646746
    3. Tripterine can inhibit expression of Eotaxin by restraining the activation of NF-kappaB in the nasal musoca of rats with allergic rhinitis. PMID: 23272499
    4. expression of Ccl11 associates with immune response modulation in experimental autoimmune encephalomyelitis PMID: 22815714
    5. Intervention of PRMT1 activity can abrogate IL-4-dependent eotaxin-1 production to influence the pulmonary inflammation with eosinophil infiltration. PMID: 22387551
    6. The expression of Eotaxin in nasal lavage fluid and nasal mucosa increased after treatment of allergic rhinitis with histamine. PMID: 20359111
    7. The expression of Eotaxin in nasal mucosa increased, and the expression of CCR3 in bone marrow increased in the model of allergic rhinitis. PMID: 16722399
    8. Suppression of eotaxin by CpG DNA reduced the symptoms of experimental allergic rhinitis. PMID: 16838745
    9. Targeting CCL11 with monoclonal antibodies possibly results in decreased myocardial fibrosis and improves contractile function after heart transplantation ub rats. PMID: 20832583
    10. Galectin-3 inhibited expression of eotaxin and IL5, potentially suppressing eosinophilic inflammation in asthma. PMID: 17074272
    11. Eotaxin is upregulated in the pancreatic lymph nodes and may play a role in early disease pathogenesis of type 1 diabetes mellitus in the BioBreeding rat model. PMID: 15557196
    12. In a model of ongoing acute heart transplant rejection in the rat, we found eotaxin mRNA expression within infiltrating macrophages, but not in mast cells PMID: 19631640

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 數(shù)據(jù)庫鏈接：