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  4. Rat Insulin-like growth factor binding protein 5,IGFBP-5 ELISA kit

Rat Insulin-like growth factor binding protein 5,IGFBP-5 ELISA kit

  • 中文名稱：
    大鼠的胰島素樣生長因子結(jié)合蛋白5(IGFBP-5)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E12784r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠的胰島素樣生長因子結(jié)合蛋白5(IGFBP-5)酶聯(lián)免疫試劑盒（CSB-E12784r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的IGFBP5含量。IGFBP5 是重要靶點(diǎn)。它是胰島素樣生長因子結(jié)合蛋白家族成員，在細(xì)胞生長、增殖、凋亡等過程發(fā)揮作用。研究顯示其可能與腫瘤發(fā)生發(fā)展相關(guān)，會通過調(diào)節(jié) IGF 活性影響下游信號通路。了解其機(jī)制或?yàn)橄嚓P(guān)疾病治療提供新思路。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，靈敏度為0.078 ng/mL。尤其適用于探究IGFBP-5在糖尿病模型、骨骼肌損傷修復(fù)或代謝綜合征相關(guān)機(jī)制研究中的動態(tài)變化，為體外實(shí)驗(yàn)提供定量分析工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Igfbp5 ELISA Kit; Igfbp-5 ELISA Kit; Insulin-like growth factor-binding protein 5 ELISA Kit; IBP-5 ELISA Kit; IGF-binding protein 5 ELISA Kit; IGFBP-5 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能參考文獻(xiàn)：
    1. Insulin growth factor binding protein 5 (IGFBP-5), insulin growth factor (IGF-1) and transforming growth factor (TGF-beta1) in the type II alveolar epithelial cells (AECs) play a key role in lung injury caused by bleomycin and pioglitazone attenuates the lung injury/fibrosis by restoring IGFBP-5 and IGF-1 and decreasing TGF-beta1 expressions in the type II AECs. PMID: 28077319
    2. Silencing IGFBP5 with small interfering RNA significantly reduced apoptosis and suppressed the expression of caspase3 in neonatal rat ventricular myocytes following treatment with methamphetamine. PMID: 25230843
    3. IGFBP5 expression was up-regulated in the striatum of methamphetamine exposed male Sprague-Dawley rats. PMID: 25127757
    4. IGFBP5 mediates high glucose-induced cardiac fibroblast activation PMID: 23417767
    5. IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation. PMID: 21598309
    6. Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A. PMID: 20167606
    7. Downregulation of IGFBP-5 gene expression may cause pulmonary hypoplasia in the nitrofen-induced CDH model by interfering with retinoid signaling pathway. PMID: 19844724
    8. Chronic exposure to high glucose leads to impaired mesangial cell migration in response to IGFBP-5 as a result of loss of laminin beta2 protein. PMID: 19864299
    9. plays an important role in the development of the anterior pituitary gland PMID: 12006713
    10. findings indicate that the modulation of rat ovarian insulin-like growth factor binding protein-4 and -5 is protein kinase C as well as protein kinase A dependent PMID: 12193414
    11. IGFBP-3 and -5 proteins may have potential modulatory roles in type I fiber-dominated muscles, aging, and regrowth from atrophy. PMID: 12397024
    12. Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I PMID: 12626499
    13. Overexpression of rat IGFBP-5 in transduced murine MC3T3 osteoblasts decreases osteoblastic function possibly by binding insulin-like growth factors in the bone microenvironment. PMID: 15589207
    14. IGF-I uses different and only partially overlapping intracellular signaling pathways for regulation of IGFBP-3 and -5 with opposing biological functions might be important for modulation of IGF bioactivity in cellular microenvironment. PMID: 15845624
    15. Although IGFBP-5 overexpression did not have an IGF-independent effect on RCJ cell differentiation, it promoted IGF-I-enhanced differentiation of these cells. PMID: 16204335
    16. Inflammatory insults decrease muscle IGFBP-5 mRNA by a TNF-dependent glucocorticoid-independent mechanism. IGF-I appears to be a dominant positive regulator of IGFBP-5 gene expression in muscle under both normal and catabolic conditions. PMID: 16339387
    17. Unique function for the laminin-9 complex in mediating IGFBP-5-induced migration. PMID: 16672690

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  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Mostly in kidney.
  • 數(shù)據(jù)庫鏈接：

    KEGG: rno:25285

    STRING: 10116.ENSRNOP00000023530

    UniGene: Rn.1593